Results 31 to 40 of about 28,776 (182)

Naturally acquired antibodies from Beninese infants promote Plasmodium falciparum merozoite-phagocytosis by human blood leukocytes: implications for control of asymptomatic malaria infections

Malaria Journal, 2022
Background Immunoglobulin G (IgG) antibodies are thought to play important roles in the protection against Plasmodium falciparum (P. falciparum) malaria.
Abdou Khadre Dit Jadir Fall, Ikhlaq Hussain Kana, Célia Dechavanne, Asier Garcia-Senosiain, Evelyne Guitard, Jacqueline Milet, Achille Massougbodji, André Garcia, Jean-Michel Dugoujon, Florence Migot-Nabias, Michael Theisen, David Courtin   +11 more
doaj   +1 more source

Erythrocyte glycophorins as receptors for Plasmodium merozoites [PDF]

Parasites & Vectors, 2019
Glycophorins are heavily glycosylated sialoglycoproteins of human and animal erythrocytes. In humans, there are four glycophorins: A, B, C and D. Glycophorins play an important role in the invasion of red blood cells (RBCs) by malaria parasites, which involves several ligands binding to RBC receptors.
Ewa Jaskiewicz, Marlena Jodłowska, Radosław Kaczmarek, Agata Zerka   +3 more
openaire   +3 more sources

Parasites at the Summit: Unexpected Geographic Distribution of the Blood Parasite Lineage Found in the Endangered Giant Lizard of Tenerife

Integrative Zoology, EarlyView.
We combined microscopic screening and molecular phylogenetic analyses to characterize blood parasites infecting Gallotia intermedia from the coastal cliffs of Montaña de Guaza and to place these infections in a broader biogeographic context. We detected apicomplexan parasites of the genus Karyolysus infecting 53.6% of G.
Rodrigo Megía‐Palma, Gonzalo Albaladejo‐Robles, Gemma Palomar, Javier Martínez, Anamarija Žagar, Alejandro Escánez‐Pérez, Miguel A. Carretero, Wiesław Babik, Santiago Merino   +8 more
wiley   +1 more source

Contrasting population structures of the genes encoding ten leading vaccine-candidate antigens of the human malaria parasite, Plasmodium falciparum. [PDF]

PLoS ONE, 2009
The extensive diversity of Plasmodium falciparum antigens is a major obstacle to a broadly effective malaria vaccine but population genetics has rarely been used to guide vaccine design.
Alyssa E Barry, Lee Schultz, Caroline O Buckee, John C Reeder   +3 more
doaj   +1 more source

PEG400 regulates Falcipain 2 activity through an allosteric mechanism

The FEBS Journal, EarlyView.
Falcipain‐2 can potentially be leveraged as a drug target due to its critical role as a haemoglobinase during the intra‐erythrocytic stage of Plasmodium falciparum. Here, we investigate the regulation of the proteolytic and haemoglobinase activity of falcipain‐2 in the presence of polyethylene glycol.
Bikram Nath, Subhoja Chakraborty, Sampa Biswas   +2 more
wiley   +1 more source

Expression of the MSPDBL2 antigen in a discrete subset of Plasmodium falciparum schizonts is regulated by GDV1 but may not be linked to sexual commitment

mBio
The Plasmodium falciparum merozoite surface protein MSPDBL2 is a polymorphic antigen targeted by acquired immune responses, and normally expressed in only a minority of mature schizonts.
Aline Freville, Lindsay B. Stewart, Kevin K. A. Tetteh, Moritz Treeck, Alfred Cortes, Till S. Voss, Sarah J. Tarr, David A. Baker, David J. Conway   +8 more
doaj   +1 more source

Aspects of immunity for the AMA-1 family of molecules in humans and non-human primates malarias

Memorias do Instituto Oswaldo Cruz, 1994
The apical membrane antigen (AMA-1) family of malaria merozoite proteins is characterised by a high degree of inter-species conservation. Evidence that the protein (PK66/AMA-1) from the simian parasite Plasmodium knowlesi was protective in rhesus monkeys
A. W. Thomas, D. Narum, A. P. Waters, J. F. Trape, C. Rogier, A. Gonçalves, V. Rosario, P. Druilhe, G. H. Mitchell, D. Dennis   +9 more
doaj   +1 more source

Transgenic selection and underlying mechanisms in apicomplexan parasites

The FEBS Journal, EarlyView.
Transgenic selection markers have driven genetic engineering in apicomplexans, enabling precise, iterative experiments. This review discusses mechanistic details of drug selection markers, strategies for marker recycling, and practical considerations for several clinically relevant parasites.
Swaroop Peddiraju, Rakhee Lohia, Nishith Gupta   +2 more
wiley   +1 more source

Nutrient Sensing and Growth Control in Plasmodium: Beyond mTOR Signaling

Molecular Microbiology, EarlyView.
Plasmodium parasites lack the canonical mTOR kinase and associated signaling complexes, yet retain key mTOR‐like functions. Parasite‐specific nutrient sensors, kinases, and translational regulators coordinate growth, stress adaptation, metabolic plasticity, and developmental decisions through a distributed regulatory network.
Felix Müller, Gabriele Pradel
wiley   +1 more source

Plasmodium chabaudi Merozoites Obtained through a Simpler Method Do Not Survive in Classically Activated Macrophages

Microorganisms
Malaria is caused by apicomplexan parasites of the Plasmodium genus. Plasmodium chabaudi is an excellent animal model for the study of human malaria caused by P. falciparum.
Pedro Souto Rodrigues, Milena de Farias Azeredo, Natália de Souza Almeida, Gisela Garcia Cabral Galaxe de Almeida, João Luiz Mendes Wanderley, Sergio Henrique Seabra, Renato Augusto DaMatta   +6 more
doaj   +1 more source