Results 31 to 40 of about 33,075 (171)

Expression and Localization Profiles of Rhoptry Proteins in Plasmodium berghei Sporozoites

Frontiers in Cellular and Infection Microbiology, 2019
In the Plasmodium lifecycle two infectious stages of parasites, merozoites, and sporozoites, efficiently infect mammalian host cells, erythrocytes, and hepatocytes, respectively.
Naohito Tokunaga, Mamoru Nozaki, Mayumi Tachibana, Minami Baba, Kazuhiro Matsuoka, Takafumi Tsuboi, Motomi Torii, Tomoko Ishino   +7 more
doaj   +1 more source

Naturally acquired antibodies to polymorphic and conserved epitopes of Plasmodium falciparum merozoite surface protein 3. [PDF]

, 2007
Many studies on the role of merozoite surface protein 3 (MSP3) in immunity against malaria have focused on a conserved section of MSP3. New evidence suggests that polymorphic sequences within MSP3 are under immune selection. We report a detailed analysis
Osier, FH, T. MWANGI, Lowe, B, Osier, FHA, B. LOWE, Marsh, K, Conway, DJ, Mwangi, T, Polley, SD, S. D. POLLEY, Marsh, Kevin, K. MARSH, F. H. A. OSIER, D. J. CONWAY   +13 more
core   +1 more source

Repeat sequences in block 2 of Plasmodium falciparum merozoite surface protein 1 are targets of antibodies associated with protection from malaria. [PDF]

, 2003
Human antibodies to the block 2 region of Plasmodium falciparum merozoite surface protein 1 (MSP1) are associated with a reduced prospective risk of clinical malaria.
Greenwood, Brian M, Conway, David J, Cavanagh, D R, Pearce, R J, McBride, Jana S, Tetteh, Kevin KA, Lloyd, J M, Polley, S D, Greenwood, B M, McBride, J S, Okenu, Daniel MN, Okenu, D M N, Conway, D J, Cavanagh, David R, Bojang, Kalifa A, Bojang, K A, Polley, Spencer D, Tetteh, K K A, Cavanagh, David, Pearce, Richard J, Lloyd, Jennifer M   +20 more
core   +1 more source

Plasmepsin X activates the PCRCR complex of Plasmodium falciparum by processing PfRh5 for erythrocyte invasion

Nature Communications, 2023
Plasmodium falciparum causes the most severe form of malaria in humans. The protozoan parasite develops within erythrocytes to mature schizonts, that contain more than 16 merozoites, which egress and invade fresh erythrocytes.
Tony Triglia, Stephen W. Scally, Benjamin A. Seager, Michał Pasternak, Laura F. Dagley, Alan F. Cowman   +5 more
doaj   +1 more source

Merozoite Proteins Discovered by qRT-PCR-Based Transcriptome Screening of Plasmodium falciparum

Frontiers in Cellular and Infection Microbiology, 2021
The development of malaria vaccines and medicines depends on the discovery of novel malaria protein targets, but the functions of more than 40% of P. falciparum genes remain unknown. Asexual parasites are the critical stage that leads to serious clinical
Nan Hou, Shanshan Li, Ning Jiang, Ning Jiang, Xianyu Piao, Yu Ma, Shuai Liu, Qijun Chen, Qijun Chen   +8 more
doaj   +1 more source

Extensive antigenic polymorphism within the repeat sequence of the Plasmodium falciparum merozoite surface protein 1 block 2 is incorporated in a minimal polyvalent immunogen. [PDF]

, 2005
Polymorphism in pathogen antigens presents a complex challenge for vaccine design. A prime example is the N-terminal block 2 region of the Plasmodium falciparum merozoite surface protein 1 (MSP1), to which allele-specific antibodies have been associated ...
Corran, P, Conway, David J, David R. Cavanagh, Cavanagh, D R, Jana S. McBride, McBride, Jana S, Tetteh, Kevin KA, Musonda, R, McBride, J S, Rosemary Musonda, Corran, Patrick, Musonda, Rosemary, Conway, D J, Cavanagh, David R, Tetteh, K K A, Patrick Corran, Cavanagh, David, David J. Conway, Kevin K. A. Tetteh   +18 more
core   +1 more source

Plasmodium falciparum GAP40 Plays an Essential Role in Merozoite Invasion and Gametocytogenesis

Microbiology Spectrum, 2023
Cyclic invasion of red blood cells (RBCs) by Plasmodium merozoites is associated with the symptoms and pathology of malaria. Merozoite invasion is powered actively and rapidly by a parasite actomyosin motor called the glideosome.
Lu He, Yue Qiu, Geping Pang, Siqi Li, Jingjing Wang, Yonghui Feng, Lumeng Chen, Liying Zhu, Yinjie Liu, Liwang Cui, Yaming Cao, Xiaotong Zhu   +11 more
doaj   +1 more source

SURGE complex of Plasmodium falciparum in the rhoptry-neck (SURFIN4.2-RON4-GLURP) contributes to merozoite invasion. [PDF]

PLoS ONE, 2018
Plasmodium falciparum invasion into red blood cells (RBCs) is a complex process engaging proteins on the merozoite surface and those contained and sequentially released from the apical organelles (micronemes and rhoptries). Fundamental to invasion is the
Maria Del Pilar Quintana, Jun-Hong Ch'ng, Arash Zandian, Maryam Imam, Kjell Hultenby, Michael Theisen, Peter Nilsson, Ulrika Qundos, Kirsten Moll, Sherwin Chan, Mats Wahlgren   +10 more
doaj   +1 more source

Temporal gene expression during asexual development of the apicomplexan Sarcocystis neurona

mSphere
Asexual replication in the apicomplexan Sarcocystis neurona involves two main developmental stages: the motile extracellular merozoite and the sessile intracellular schizont.
Sriveny Dangoudoubiyam, Jamie K. Norris, Sivaranjani Namasivayam, Rodrigo de Paula Baptista, Naila Cannes do Nascimento, Joseph Camp, Christopher L. Schardl, Jessica C. Kissinger, Daniel K. Howe   +8 more
doaj   +1 more source

Efficient measurement of opsonising antibodies to Plasmodium falciparum merozoites. [PDF]

PLoS ONE, 2012
Antibodies targeting merozoites are important in protection from malaria. Therefore, merozoite surface proteins are attractive vaccine candidates. There is a need for robust functional assays to investigate mechanisms of acquired immunity and vaccine ...
Danika L Hill, Emily M Eriksson, Amandine B Carmagnac, Danny W Wilson, Alan F Cowman, Diana S Hansen, Louis Schofield   +6 more
doaj   +1 more source