Results 91 to 100 of about 444,796 (301)

Sparse evidence of MERS-CoV infection among animal workers living in Southern Saudi Arabia during 2012 [PDF]

, 2015
Middle East respiratory syndrome coronavirus (MERS-CoV) is an emerging viral pathogen that primarily causes respiratory illness. We conducted a seroprevalence study of banked human serum samples collected in 2012 from Southern Saudi Arabia. Sera from 300
Alsahly, A, Anderson, BD, Gray, GC, Heil, GL, Khan, SU, Masri, MA, Memish, ZA, Peiris, JSM   +7 more
core   +1 more source

PIM1 Attenuates Innate Immunity to Foster Coronavirus Replication through Ubiquitin Ligase β‐TrCP‐Mediated IFNAR1 Degradation

Advanced Science, EarlyView.
Hijacking Host Kinase PIM1: A β‐Coronavirus (OC43) strategy to degrade IFNAR1 and evade antiviral immunity. Human β‐coronaviruses (OC43) exploit the proto‐oncoprotein PIM1 kinase to sabotage innate immunity. Viral RNA/proteins upregulate PIM1, which phosphorylates E3 ligase β‐TrCP1.
Qianya Wan, Lin Zhu, Cien Chen, Li Zhong, Houying Leung, Wei Li, Chang Xu, Xi Yao, Huan Hu, Mandi Wu, Yuxin Hou, Hin Chu, Yiran Wang, Sheng Chen, Mingyu Pan, Zongwei Cai, Ming‐liang He   +16 more
wiley   +1 more source

COVID-19 in the Shadows of MERS-CoV in the Kingdom of Saudi Arabia

Journal of Epidemiology and Global Health, 2020
Middle East Respiratory Syndrome Coronavirus (MERS-CoV) has plagued the Middle East since it was first reported in 2012. Recently, at the end of December 2019, a cluster of pneumonia cases were reported from Wuhan city, Hubei Province, China, linked to a
M. Barry, M. Al Amri, Z. Memish
semanticscholar   +1 more source

MERS-CoV: Bridging the Knowledge Gaps

Oman Medical Journal, 2014
Since its emergence in September 2012 and as of 30 April 2014, there have been 424 cases of the Middle East Respiratory Syndrome-Coronavirus (MERS-CoV) reported to public health authorities worldwide (15 countries). This tally includes 95 healthcare workers (22%) and 131 deaths (mortality rate of 31%).1 To date, only two laboratory confirmed cases have
Zakaria Al Muharrmi, Khuloud Al Maamari, Fatma Ba Alawi, Abdullah Balkhair, Osama Ahmed   +4 more
openaire   +4 more sources

MERS-CoV: the intermediate host identified? [PDF]

The Lancet Infectious Diseases, 2013
As of Aug 2, 2013, Middle East respiratory syndrome coronavirus (MERS-CoV) has caused 94 human cases—with most having severe respiratory disease—46 of these patients have died.1 Cases have been reported in Jordan, Qatar, United Arab Emirates, Saudi Arabia, France, Germany, Italy, the UK, and Tunisia.
Emmie de Wit, Vincent J. Munster
openaire   +3 more sources

Middle East respiratory syndrome coronavirus in the last two years: Health care workers still at risk [PDF]

, 2019
This article is made available for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source.
Al-Tawfiq, Jaffar A., Memish, Ziad A.
core   +1 more source

Studying Evolutionary Adaptation of MERS-CoV [PDF]

, 2019
Forced viral adaptation is a powerful technique employed to study the ways viruses may overcome various selective pressures that reduce viral replication. Here, we describe methods for in vitro serial passaging of Middle East respiratory syndrome coronavirus (MERS-CoV) to select for mutations which increase replication on semi-permissive cell lines as ...
Michael Letko, Vincent J. Munster
openaire   +3 more sources

Host Determinants of MERS-CoV Transmission and Pathogenesis [PDF]

Viruses, 2019
Middle East respiratory syndrome coronavirus (MERS-CoV) is a zoonotic pathogen that causes respiratory infection in humans, ranging from asymptomatic to severe pneumonia. In dromedary camels, the virus only causes a mild infection but it spreads efficiently between animals.
W. Widagdo, Syriam Sooksawasdi Na Ayudhya, Gadissa B. Hundie, Bart L. Haagmans   +3 more
openaire   +5 more sources

MERS-CoV Confirmation among 6,873 suspected persons and relevant Epidemiologic and Clinical Features, Saudi Arabia — 2014 to 2019

EClinicalMedicine, 2021
Background: Of the three lethal coronaviruses, in addition to the ongoing pandemic-causing SARS-CoV 2, Middle East Respiratory Syndrome Coronavirus (MERS-CoV) remains in circulation. Information on MERS-CoV has relied on small sample of patients.
Shahul H. Ebrahim, MD, PhD, Andrew D. Maher, MPH, Udhayashankar Kanagasabai, MD, MPH, Sarah H. Alfaraj, MD, Nojom A. Alzahrani, Saleh A. Alqahtani, MD, Abdullah M. Assiri, MD, Ziad A. Memish, MD   +7 more
doaj  

MERS-CoV (Middle East Respiratory Syndrome Coronavirus) outside the Arabian Peninsula an One Health approach: Understanding the role of wildlife, livestock and human in the virus dynamic [PDF]

, 2016
One of the big paradoxes of the MERS-CoV epidemiology is the apparent lack of human cases in large parts Africa where the virus and an animal host, the dromedary camel, are present.
Akhmetsadykov, Nourlan, Ayelet, Gelagay, Baubekova, Almagul, Ben Bencheikh, M.N., Bourgarel, Mathieu, Boussini, H., Chevalier, Véronique, Chu, Daniel K.W., El Berbri, Ikhlass, Fassi-Fihri, Ouafaa, Faye, Bernard, Fekadu, G., Grosbois, Vladimir, Maher, W., Miguel, Eve, Peiris, Malik, Perera, Ranawaka A.P.M., Roche, Benjamin, Roger, François, Shimekit, D., Traoré, Amadou, Van Kerkhove, Maria D.   +21 more
core