Results 91 to 100 of about 75,632 (172)
Pandemic Prevention Paradigms: Understanding Global Health Governance
Public Health Challenges, Volume 4, Issue 2, June 2025.One Health is an emerging area of integrative studies and interventions aimed at preventing zoonotic diseases by addressing human, animal, and environmental interactions. A fundamental aspect of the concept is understanding how these interactions influence health outcomes among humans, animals, and ecosystems. Developed initially to respond to the need
Soheil Sadr +10 more
wiley +1 more source
Development of Monoclonal Antibody and Diagnostic Test for Middle East Respiratory Syndrome Coronavirus Using Cell-Free Synthesized Nucleocapsid Antigen [PDF]
, 2016 Protein nativity is one of the most critical factors for the quality of antigens used as immunogens and the reactivities of the resultant antibodies. The preparation and purification of native viral antigens in conventional cell-based protein expression ...
Akihide eRyo +11 more
core +2 more sources
Middle East respiratory syndrome coronavirus (MERS-CoV) in dromedary camels in Nigeria, 2015 [PDF]
, 2015 Evidence of current and past Middle East respiratory syndrome coronavirus (MERS-CoV) infection in dromedary camels slaughtered at an abattoir in Kano, Nigeria in January 2015, was sought by reverse transcription-quantitative polymerase chain reaction (RT-
Chan, MS +6 more
core +1 more source
Quantitative Biology, Volume 13, Issue 2, June 2025.Abstract The transcriptome, the complete set of RNA molecules within a cell, plays a critical role in regulating physiological processes. The advent of RNA sequencing (RNA‐seq) facilitated by Next Generation Sequencing (NGS) technologies, has revolutionized transcriptome research, providing unique insights into gene expression dynamics.
Jorge A. Tzec‐Interián +2 more
wiley +1 more source
Land Use Change and Infectious Disease Emergence
Reviews of Geophysics, Volume 63, Issue 2, June 2025.Abstract Major infectious diseases threatening human health are transmitted to people from animals or by arthropod vectors such as insects. In recent decades, disease outbreaks have become more common, especially in tropical regions, including new and emerging infections that were previously undetected or unknown. Even though there is growing awareness
M. Cristina Rulli +6 more
wiley +1 more source
Acta Crystallographica Section D, Volume 81, Issue 6, Page 310-326, June 2025.The myricetin‐bound crystal structure of the SARS‐CoV‐2 helicase reveals a conserved allosteric binding site. Guided by these structural insights, caffeic acid derivatives identified through virtual screening were experimentally validated as novel natural inhibitors of NSP13.The SARS‐CoV‐2 helicase NSP13 is a highly conserved and essential component of
Patrick Kloskowski +5 more
wiley +1 more source
Sufficient reproduction numbers to prevent recurrent epidemics
Methods in Ecology and Evolution, Volume 16, Issue 6, Page 1186-1200, June 2025.Abstract Current practice in the design and evaluation of control measures in disease ecology and epidemiology, including vaccination, is largely based on reproduction numbers (RNs), which represent prognostic indices of long‐term disease transmission, both in naïve populations (basic RN) and in the presence of prior exposure or infection containment ...
Lorenzo Mari +3 more
wiley +1 more source
Little is known about the effects of Middle East respiratory syndrome coronavirus (MERS-CoV) during pregnancy. In Saudi Arabia, 5 cases of MERS-CoV infection among pregnant women were reviewed, and all cases resulted in adverse outcomes.
core +3 more sources
Derivatives of MOPS: promising scaffolds for SARS coronaviruses Macro domain‐targeted inhibition
The FEBS Journal, Volume 292, Issue 11, Page 2865-2881, June 2025.The SARS‐CoV/CoV‐2 genome encodes non‐structural protein 3, which contains a ‘Macro domain’. This protein domain exhibits antagonistic activity against interferon signaling, which disrupts the host innate immune response and can thus mediate viral escape, highlighting its therapeutic potential.
Oney Ortega Granda +5 more
wiley +1 more source
Permissivity of Dipeptidyl Peptidase 4 Orthologs to Middle East Respiratory Syndrome Coronavirus Is Governed by Glycosylation and Other Complex Determinants [PDF]
, 2017 Middle East respiratory syndrome coronavirus (MERS-CoV) utilizes dipeptidyl peptidase 4 (DPP4) as an entry receptor. While bat, camel, and human DPP4 support MERS-CoV infection, several DPP4 orthologs, including mouse, ferret, hamster, and guinea pig ...
Baric, Ralph S. +6 more
core +2 more sources