Results 31 to 40 of about 75,632 (172)

Middle East respiratory syndrome coronavirus in pediatrics: a report of seven cases from Saudi Arabia [PDF]

, 2018
This article is made available for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source.
Al-Tawfiq, Jaffar A., Alfaraj, Sarah H., Altuwaijri, Talal A., Memish, Ziad A.   +3 more
core   +1 more source

Middle East respiratory syndrome coronavirus in dromedary camels: An outbreak investigation [PDF]

, 2014
Background: Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe lower respiratory tract infection in people. Previous studies suggested dromedary camels were a reservoir for this virus.
Al Dhahiry, S.H.S. (Said), Al Khal, A. (Abdullatif), Al Romaihi, H.E. (Hamad), Al-Marri, S.A. (Salih), Al-Thani, M. (Mohamed), Alhajri, F. (Farhoud), AlHajri, M.M. (Mohd), Bermingham, A. (Alison), Diab, A. (Ayman), Farag, E. (Elmoubasher), Galiano, M. (Monica), Ghobashy, H. (Hazem), Godeke, G-J. (Gert-Jan), Haagmans, B.L. (Bart), Jonges, M. (Marcel), Koopmans D.V.M., M.P.G. (Marion), Myers, R.H. (Richard), Osterhaus, A.D.M.E. (Albert), Raj, V.S. (Stalin), Reusken, C.B.E.M. (Chantal)   +19 more
core   +1 more source

MERS-CoV: in search of answers [PDF]

The Lancet, 2013
Middle East Respiratory Syndrome coronavirus (MERS-CoV) has been a cause for concern for months, with a steady trickle of new cases, often fatal, dating back to April, 2012. Until March of this year there were fewer than fi ve confi rmed infections per month, but April and May each saw 19 new cases, driven up by a cluster in the Al-Ahsa region in ...
openaire   +2 more sources

Influenza is more common than Middle East Respiratory Syndrome Coronavirus (MERS-CoV) among hospitalized adult Saudi patients [PDF]

, 2017
Background Since the initial description of Middle East Respiratory Syndrome Coronavirus (MERS-CoV), we adopted a systematic process of screening patients admitted with community acquired pneumonia.
Al-Tawfiq, Jaffar A., Hinedi, Kareem, Rabaan, Ali A.   +2 more
core   +1 more source

MERS-CoV spillover at the camel-human interface [PDF]

eLife, 2017
Middle East respiratory syndrome coronavirus (MERS-CoV) is a zoonotic virus from camels causing significant mortality and morbidity in humans in the Arabian Peninsula. The epidemiology of the virus remains poorly understood, and while case-based and seroepidemiological studies have been employed extensively throughout the epidemic, viral sequence data ...
Dudas, Gytis, Carvalho, Luiz Max, Rambaut, Andrew, Bedford, Trevor, Somily, Ali M., Barry, Mazin, Al Subaie, Sarah S., BinSaeed, Abdulaziz A., Alzamil, Fahad A., Zaher, Waleed, Qahtani, Theeb Al, Jerian, Khaldoon Al, McNabb, Scott J.N., Al-Jahdali, Imad A., Alotaibi, Ahmed M., Batarfi, Nahid A., Cotten, Matthew, Watson, Simon J., Binter, Spela, Kellam, Paul   +19 more
openaire   +5 more sources

The impact of co-infection of influenza A virus on the severity of Middle East Respiratory Syndrome Coronavirus [PDF]

, 2017
This article is made available for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source.
Al-Tawfiq, Jaffar A., Alfaraj, Sarah H., Altwaijri, Talal A., Alzahrani, Nojoom A., Memish, Ziad A.   +4 more
core   +1 more source

Dual‐Locking the SARS‐CoV‐2 Spike Trimer: An Amphipathic Molecular “Bolt” Stabilizes Conserved Druggable Interfaces for Coronavirus Inhibition

Advanced Science, EarlyView.
A new amphipathic molecule, S416 is discovered, that locks the SARS‐CoV‐2 spike protein in its closed state, blocking viral entry. S416 acts as a molecular bolt, binding six sites: three between adjacent RBDs and three connecting NTDs to RBDs. This dual‐locking mechanism stiffens the spike structure and reduces its flexibility.
Shiliang Li, Fang Ye, Yucheng Zheng, Jie Wang, Haoran Peng, Lili Zhu, Lili Chen, Tao Yu, Huan Ge, Jiaqi He, Binghao Zhang, Jiayun Wu, Zhiyi Zhang, Liangliang Jiang, Geng Chen, Ping Zhao, Ke Lan, Zhenjiang Zhao, Xuhong Qian, Ke Xu, Yang Du, Honglin Li   +21 more
wiley   +1 more source

Trypstatin as a Novel TMPRSS2 Inhibitor with Broad‐Spectrum Efficacy against Corona and Influenza Viruses

Advanced Science, EarlyView.
Trypstatin, a 61‐amino acid Kunitz‐type protease inhibitor derived from human Bikunin, potently inhibits TMPRSS2 and related proteases. It blocks spike‐ and hemagglutinin‐mediated entry of multiple respiratory viruses in vitro reduces SARS‐CoV‐2 replication in human airway cultures, and lowers viral load and symptoms in infected hamsters, demonstrating
Jan Lawrenz, Lukas Wettstein, Armando Rodríguez Alfonso, Rayhane Nchioua, Pascal von Maltitz, Dan Pascal Jean Albers, Fabian Zech, Julie Vandeput, Lieve Naesens, Giorgio Fois, Veronika Neubauer, Nico Preising, Emilia Schmierer, Yasser Almeida‐Hernandez, Moritz Petersen, Ludger Ständker, Sebastian Wiese, Peter Braubach, Manfred Frick, Eberhard Barth, Daniel Sauter, Frank Kirchhoff, Elsa Sanchez‐Garcia, Annelies Stevaert, Jan Münch   +24 more
wiley   +1 more source

Promising Prodiginins Biological Activities

Chemistry &Biodiversity, EarlyView.
ABSTRACT Prodiginins are a large family of at least 34 pyrrolic compounds, including the well‐studied red pigment prodigiosin. Prodiginins are produced by several microorganisms displaying broad biological activities, including antimicrobial, antiviral, antiparasitic, antiproliferative, and immunosuppressive activities.
María F. Ladetto, Melisa E. Gantner, Boris E. Rodenak‐Kladniew, Santiago Rodriguez, María L. Cuestas, Alan Talevi, Guillermo R. Castro   +6 more
wiley   +1 more source

MERS-CoV: Bridging the Knowledge Gaps

Oman Medical Journal, 2014
Since its emergence in September 2012 and as of 30 April 2014, there have been 424 cases of the Middle East Respiratory Syndrome-Coronavirus (MERS-CoV) reported to public health authorities worldwide (15 countries). This tally includes 95 healthcare workers (22%) and 131 deaths (mortality rate of 31%).1 To date, only two laboratory confirmed cases have
Zakaria Al Muharrmi, Khuloud Al Maamari, Fatma Ba Alawi, Abdullah Balkhair, Osama Ahmed   +4 more
openaire   +4 more sources