Results 41 to 50 of about 81,795 (214)

Cross host transmission in the emergence of MERS coronavirus [PDF]

, 2016
Coronaviruses (CoVs) able to infect humans emerge through cross-host transmission from animals. There is substantial evidence that the recent Middle East respiratory syndrome (MERS)-CoV outbreak is fueled by zoonotic transmission from dromedary camels ...
Haagmans, B.L. (Bart), Koopmans D.V.M., M.P.G. (Marion), Raj, V.S. (Stalin), Reusken, C.B.E.M. (Chantal)   +3 more
core   +1 more source

MERS-CoV: Understanding the latest human coronavirus threat [PDF]

, 2018
Human coronaviruses cause both upper and lower respiratory tract infections in humans. In 2012, a sixth human coronavirus (hCoV) was isolated from a patient presenting with severe respiratory illness.
Almazan, Borucki, Hijawi, Holmes, Huh, Mohammed   +5 more
core   +2 more sources

MERS-CoV at the animal–human interface: inputs on exposure pathways from an expert-opinion elicitation [PDF]

, 2016
Nearly 4 years after the first report of the emergence of Middle-East respiratory syndrome Coronavirus (MERS-CoV) and nearly 1800 human cases later, the ecology of MERS-CoV, its epidemiology, and more than risk factors of MERS-CoV transmission between ...
Anna Funk, Bernard Faye, Eve Miguel, Flavie Luce Goutard, FRANCOIS LOUIS ROGER, JS Malik Peiris, JS Malik Peiris, Maria D Van Kerkhove, Mathieu Bourgarel, Veronique Chevalier   +9 more
core   +2 more sources

Nanomaterial‐Based Optical Biosensors for SARS‐CoV‐2 Detection: A Retrospective of the Pandemic

Advanced Sensor Research, EarlyView.
This review discusses nanomaterial‐based optical biosensors developed for or adapted to the detection of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). It concludes by providing a perspective on how lessons learned during the coronavirus disease of 2019 (COVID‐19) pandemic may be applied for future research on nanomaterial‐based ...
Flavie Martin, Scott G. Harroun, Michel Meunier   +2 more
wiley   +1 more source

Limited Genetic Diversity Detected in Middle East Respiratory Syndrome-Related Coronavirus Variants Circulating in Dromedary Camels in Jordan

Viruses, 2021
Middle East respiratory syndrome-related coronavirus (MERS-CoV) is a persistent zoonotic pathogen with frequent spillover from dromedary camels to humans in the Arabian Peninsula, resulting in limited outbreaks of MERS with a high case-fatality rate ...
Stephanie N. Seifert, Jonathan E. Schulz, Stacy Ricklefs, Michael Letko, Elangeni Yabba, Zaidoun S. Hijazeen, Peter Holloway, Bilal Al-Omari, Hani A. Talafha, Markos Tibbo, Danielle R. Adney, Javier Guitian, Nadim Amarin, Juergen A. Richt, Chester McDowell, John Steel, Ehab A. Abu-Basha, Ahmad M. Al-Majali, Neeltje van Doremalen, Vincent J. Munster   +19 more
doaj   +1 more source

Human Schlafen 14 Cleavage of Short Double‐Stranded RNAs Underpins its Antiviral Activity

Advanced Science, EarlyView.
SLFN14 is associated with human diseases. SLFN14 is found to cleave RNAs containing short duplexes. The cryo‐EM structures of SLFN14 and SLFN14‐hairpin RNA complex reveal that SLFN14 assembles into a ring‐like dimer; two RNase domains form an RNA‐binding groove accommodating a hairpin RNA.
Mengyun Li, Dapeng Sun, Wei Hao, Hua Fu, Yueli Zhang, Zhijian Li, Bo Qin, Yumei Wang, Sheng Cui   +8 more
wiley   +1 more source

Sparse evidence of MERS-CoV infection among animal workers living in Southern Saudi Arabia during 2012 [PDF]

, 2015
Middle East respiratory syndrome coronavirus (MERS-CoV) is an emerging viral pathogen that primarily causes respiratory illness. We conducted a seroprevalence study of banked human serum samples collected in 2012 from Southern Saudi Arabia. Sera from 300
Alsahly, A, Anderson, BD, Gray, GC, Heil, GL, Khan, SU, Masri, MA, Memish, ZA, Peiris, JSM   +7 more
core   +1 more source

PIM1 Attenuates Innate Immunity to Foster Coronavirus Replication through Ubiquitin Ligase β‐TrCP‐Mediated IFNAR1 Degradation

Advanced Science, EarlyView.
Hijacking Host Kinase PIM1: A β‐Coronavirus (OC43) strategy to degrade IFNAR1 and evade antiviral immunity. Human β‐coronaviruses (OC43) exploit the proto‐oncoprotein PIM1 kinase to sabotage innate immunity. Viral RNA/proteins upregulate PIM1, which phosphorylates E3 ligase β‐TrCP1.
Qianya Wan, Lin Zhu, Cien Chen, Li Zhong, Houying Leung, Wei Li, Chang Xu, Xi Yao, Huan Hu, Mandi Wu, Yuxin Hou, Hin Chu, Yiran Wang, Sheng Chen, Mingyu Pan, Zongwei Cai, Ming‐liang He   +16 more
wiley   +1 more source

Middle East respiratory syndrome coronavirus in the last two years: Health care workers still at risk [PDF]

, 2019
This article is made available for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source.
Al-Tawfiq, Jaffar A., Memish, Ziad A.
core   +1 more source

MERS-CoV Confirmation among 6,873 suspected persons and relevant Epidemiologic and Clinical Features, Saudi Arabia — 2014 to 2019

EClinicalMedicine, 2021
Background: Of the three lethal coronaviruses, in addition to the ongoing pandemic-causing SARS-CoV 2, Middle East Respiratory Syndrome Coronavirus (MERS-CoV) remains in circulation. Information on MERS-CoV has relied on small sample of patients.
Shahul H. Ebrahim, MD, PhD, Andrew D. Maher, MPH, Udhayashankar Kanagasabai, MD, MPH, Sarah H. Alfaraj, MD, Nojom A. Alzahrani, Saleh A. Alqahtani, MD, Abdullah M. Assiri, MD, Ziad A. Memish, MD   +7 more
doaj