Results 41 to 50 of about 75,632 (172)

MERS-CoV: the intermediate host identified? [PDF]

The Lancet Infectious Diseases, 2013
As of Aug 2, 2013, Middle East respiratory syndrome coronavirus (MERS-CoV) has caused 94 human cases—with most having severe respiratory disease—46 of these patients have died.1 Cases have been reported in Jordan, Qatar, United Arab Emirates, Saudi Arabia, France, Germany, Italy, the UK, and Tunisia.
Emmie de Wit, Vincent J. Munster
openaire   +3 more sources

MERS-CoV: Understanding the latest human coronavirus threat [PDF]

, 2018
Human coronaviruses cause both upper and lower respiratory tract infections in humans. In 2012, a sixth human coronavirus (hCoV) was isolated from a patient presenting with severe respiratory illness.
Almazan, Borucki, Hijawi, Holmes, Huh, Mohammed   +5 more
core   +2 more sources

Structure−Activity Relationships of New 1‐Aryl‐1H‐Indole Derivatives as SARS‐CoV‐2 Nsp13 Inhibitors

ChemMedChem, EarlyView.
SARS‐CoV‐2 nsp13 is a promising target to develop effective antivirals. Pursuing the studies, new indolyl derivatives to deepen SARs are designed. The newly synthesized N‐aryl indoles are active vs both nsp13‐associated activities. They exert antiviral activity vs SARS‐CoV‐2 infected cells with no cytotoxicity.
Valentina Noemi Madia, Roberta Emmolo, Elisa Patacchini, Donatella Amatore, Stefania Maloccu, Davide Ialongo, Aurora Albano, Giuseppe Ruggieri, Emanuele Cara, Laura Zarbo, Antonella Messore, Riccardo De Santis, Alessandra Amoroso, Florigio Lista, Francesca Esposito, Enzo Tramontano, Angela Corona, Roberto Di Santo, Roberta Costi   +18 more
wiley   +1 more source

Evaluating MERS-CoV Entry Pathways [PDF]

, 2019
Middle East respiratory syndrome coronavirus (MERS-CoV) is an emerging zoonotic pathogen with a broad host range. The extent of MERS-CoV in nature can be traced to its adaptable cell entry steps. The virus can bind host-cell carbohydrates as well as proteinaceous receptors.
Gautami G. Galpalli, Enya Qing, Tom Gallagher, Michael P. Hantak   +3 more
openaire   +3 more sources

Cross host transmission in the emergence of MERS coronavirus [PDF]

, 2016
Coronaviruses (CoVs) able to infect humans emerge through cross-host transmission from animals. There is substantial evidence that the recent Middle East respiratory syndrome (MERS)-CoV outbreak is fueled by zoonotic transmission from dromedary camels ...
Haagmans, B.L. (Bart), Koopmans D.V.M., M.P.G. (Marion), Raj, V.S. (Stalin), Reusken, C.B.E.M. (Chantal)   +3 more
core   +1 more source

The Antiviral Activity of Polyphenols

Molecular Nutrition &Food Research, EarlyView.
Polyphenols demonstrate remarkable antiviral properties by effectively disrupting multiple biochemical processes essential for viral replication. ABSTRACT Polyphenols are secondary metabolites produced by a large variety of plants. These compounds that comprise the class of phenolic acids, stilbenes, lignans, coumarins, flavonoids, and tannins have a ...
Markus Burkard, Alban Piotrowsky, Christian Leischner, Katja Detert, Sascha Venturelli, Luigi Marongiu   +5 more
wiley   +1 more source

Studying Evolutionary Adaptation of MERS-CoV [PDF]

, 2019
Forced viral adaptation is a powerful technique employed to study the ways viruses may overcome various selective pressures that reduce viral replication. Here, we describe methods for in vitro serial passaging of Middle East respiratory syndrome coronavirus (MERS-CoV) to select for mutations which increase replication on semi-permissive cell lines as ...
Michael Letko, Vincent J. Munster
openaire   +3 more sources

Crystal Structure of the Receptor-Binding Domain from Newly Emerged Middle East Respiratory Syndrome Coronavirus [PDF]

, 2013
The newly emerged Middle East respiratory syndrome coronavirus (MERS-CoV) has infected at least 77 people, with a fatality rate of more than 50%. Alarmingly, the virus demonstrates the capability of human-to-human transmission, raising the possibility of
Chang Liu, Fang Li, Kanagalaghatta R. Rajashankar, Ralph S. Baric, Sudhakar S. Agnihothram, Yang Yang, Yaoqing Chen, Yi-Lun Lin   +7 more
core   +2 more sources

Transforming Niclosamide through Nanotechnology: A Promising Approach for Long COVID Management

Small, EarlyView.
This review highlights the transformation of niclosamide, a repurposed drug, through molecular science strategies to overcome its pharmacokinetic limitations. Emphasizing novel nanohybrid technologies and delivery platforms, the article explores their therapeutic potential in targeting the complex pathophysiology of long COVID, paving the way for ...
Sanoj Rejinold N, Goeun Choi, Geun‐woo Jin, Jin‐Ho Choy   +3 more
wiley   +1 more source

Mers-CoV and Zika Virus [PDF]

, 2017
Chapter 6 analyses the recent emergence of Mers-CoV and the spread of Zika virus around the globe. With a glace into the future, especially with regard to emerging infectious diseases (EID), it explores the most important indicators of such emergence and spread, asking which local, national, and international characteristics come to the fore to ...
openaire   +2 more sources