Results 141 to 150 of about 340,715 (262)
It's a Gas: Bioconjugation With Vapor‐Phase Reagents
Gaseous reagents are an emerging class of bioconjugation reagents that can offer alternative selectivity paradigms for the construction of precise bioconjugates. A variety of both inert and highly reactive gases have recently been developed for bioconjugation use.
Yuxuan Ding, Jun Ohata, Zachary T. Ball
wiley +1 more source
Mer ansvar - mer frigjøring? [PDF]
openaire +1 more source
Whispers of Pathogens; Social Contagion in Infectious Disease Dynamics: A Review
ABSTRACT Background and Aims Infectious disease dynamics are deeply intertwined with social structures, behaviors, and information systems. This narrative review examines how social factors conceptualized through the integrated lens of “social contagion” within a syndemic framework shape infectious disease patterns from January 2000 to January 2024 ...
Sayed Mortaza Fayez
wiley +1 more source
ABSTRACT Background and Aim Janus kinases/signal transducers and activators of transcription (JAK/STAT) pathway is crucial for various stages of immunity, from innate to adaptive responses. Type 1 IFNs activate JAK/STAT pathway by binding to receptors on JAK, phosphorylating STAT and upregulating interferon‐stimulated genes (ISGs) leading to cytokines ...
Esimebia Adjovi Amegashie +7 more
wiley +1 more source
ABSTRACT Background Since December 2019, SARS‐CoV‐2 has infected over 700 million people and caused > 7 million deaths. While much of the global north was severely affected, sub‐Saharan Africa was relatively spared. Possible reasons include a younger population, fewer comorbidities, and pre‐existing immunity.
Robert J. Samuels +11 more
wiley +1 more source
Carbohydrate‐Based Drug Discovery: Synthetic Strategies and Clinical Applications
The picture depicts the molecules discussed in the review. On the left side, the general scaffold of sugars is shown. Next to it are four carbohydrate‐based molecules, including remdesivir, islatravir, empagliflozin, and Globo‐H. Remdesivir and islatravir contain a substituted ribose ring attached to a modified nucleobase.
Stephan Scheeff +2 more
wiley +1 more source
Isocitrate Dehydrogenase Mutations in Cancer: From Bench to Bedside Applications
Mutant isocitrate dehydrogenase affects multiple cancer types. Alterations in IDH1 and IDH2 result in abnormal enzyme activity, leading to the overproduction of D‐2‐hydroxyglutarate (D‐2HG). This metabolite disrupts cellular metabolism and epigenetic regulation, driving cancer initiation, progression, and metastasis.
Yuhan Fang +6 more
wiley +1 more source
Molecular Detection of Alpha‐ and Betacoronaviruses in Bats from Afar Region, Ethiopia
Bats are critical reservoirs of coronaviruses, yet gaps remain in understanding coronavirus diversity within bat populations in Eastern Ethiopia. A total of 141 bats were captured: 129 Chaerephon pumilus, 11 Epomophorus labiatus and 1 Mops condylurus. Coronaviruses detected in eight bats.
Bula Mengesha +2 more
wiley +1 more source
Hyper-k-mers: Efficient Streaming k-mers Representation
AbstractK-mers have become ubiquitous in modern bioinformatics pipelines. A key factor in their success is the ability to filter out erroneousk-mers by removing those with low abundances. However, large numbers of distinctk-mers make counting a memory-intensive step. Early tools addressed this issue by storingk-mers on disk.
Martayan, Igor +4 more
openaire +1 more source

