Results 81 to 90 of about 13,648 (298)

Bioavailability and swallowability of an age-appropriate, delayed-release mesalamine formulation in healthy volunteers

open access: yesClinical Pharmacology: Advances and Applications, 2019
Abhijeet Jakate,1 Brian McNamee,2 Donald Burkindine31Clinical Pharmacology, Allergan plc, Madison, NJ, USA; 2Clinical Pharmacology, Allergan Biologics Ltd, Liverpool, UK; 3QPS Bio-Kinetic, Springfield, MO, USAObjective: Delayed-release mesalamine 400 mg ...
Jakate A, McNamee B, Burkindine D
doaj  

Efficacy and Tolerance of 5-Aminosalicylic Acid Suppositories in the Treatment of Ulcerative Proctitis: A Review of Two Double-Blind, Placebo Controlled Trials

open access: yesCanadian Journal of Gastroenterology, 1990
The efficacy and tolerance of 500 mg 5-aminosalicylic acid (mesalamine) suppositories in the treatment of ulcerative proctitis were assessed in two double-blind, placebo controlled studies of six weeks' duration, involving a total of 173 patients.
CN Williams
doaj   +1 more source

Medications as a Source of Human Exposure to Phthalates. [PDF]

open access: yes, 2012
Phthalates are a group of multifunctional chemicals used in consumer and personal care products, plastics, and medical devices. Laboratory studies show that some phthalates are reproductive and developmental toxicants.
Calafat, Antonia M   +3 more
core   +1 more source

Isolated fever induced by mesalamine treatment

open access: yesWorld Journal of Gastroenterology, 2013
Adverse reactions to mesalamine, a treatment used to induce and maintain remission in inflammatory bowel diseases, particularly ulcerative colitis, have been described in the literature as case reports. This case illustrates an unusual adverse reaction.
Roy Nasnas   +7 more
openaire   +2 more sources

The Role of IgE in Crohn's Disease by Impairing the Capacity of Plasmacytoid Dendritic Cells to Generate FOXP3+ Tregs

open access: yesAllergy, EarlyView.
We uncover an unprecedented role for IgE in CD. CD patients, regardless of allergic status and similar to allergic patients, display higher levels of circulating IgE+ and FcεRI+ immune cells, including pDCs, which are concomitant to fewer Tregs. In vitro experiments show that the anti‐IgE monoclonal antibody omalizumab restores the ability of pDCs from
Andrés de la Rocha‐Muñoz   +11 more
wiley   +1 more source

The Polyphosphate Kinase of Escherichia coli Is Required for Full Production of the Genotoxin Colibactin

open access: yesmSphere, 2020
Colibactin induces DNA damage in mammalian cells and has been linked to the virulence of Escherichia coli and the promotion of colorectal cancer (CRC). By looking for mutants attenuated in the promoter activity of clbB encoding one of the key enzymes for
Min Tang-Fichaux   +5 more
doaj   +1 more source

Differential diagnosis problem of pulmonary changes in ulcerative colitis [PDF]

open access: yesVojnosanitetski Pregled, 2010
Introduction. Inflammatory intestinal diseases are often accompanied with extraintestinal and even pulmonary manifestations. The treatment of these intestinal diseases includes sulphasalazine and mesalazine, which may have undesirable allergic and other ...
Đurić Mirna   +3 more
doaj   +1 more source

Preformulation Considerations Development and Evaluation of Mesalamine Loaded Polysaccharide-Based Complex Mucoadhesive Beads for Colon Targeting

open access: yes, 2021
Background: Inflammatory bowel disease (IBD) is a chronic inflammatory disease of large intestine consisting of ulcerative colitis and Crohn’s disease. Mesalamine is a first line drug use for the treatment but it has drawback of low water solubility and ...
Rohitas Deshmukh, Ranjit Kumar
semanticscholar   +1 more source

Adjustment of Surveillance Intervals for Ulcerative Colitis‐Associated Neoplasia Based on Disease Duration

open access: yesDigestive Endoscopy, EarlyView.
ABSTRACT Objectives The risk of colitis‐associated cancer increases with disease duration in ulcerative colitis (UC), yet surveillance colonoscopy protocols generally stratify risk uniformly for patients with disease lasting over 8 years. This study evaluated whether shorter surveillance intervals might enhance lesion detection rates in patients with ...
Ryoya Sakakibara   +13 more
wiley   +1 more source

Induction of Colonic Regulatory T Cells by Mesalamine by Activating the Aryl Hydrocarbon ReceptorSummary

open access: yesCellular and Molecular Gastroenterology and Hepatology, 2017
Background & Aims: Mesalamine is a first-line drug for treatment of inflammatory bowel diseases (IBD). However, its mechanisms are not fully understood. CD4+ Foxp3+ regulatory T cells (Tregs) play a potential role in suppressing IBD.
Kyoko Oh-oka   +11 more
doaj  

Home - About - Disclaimer - Privacy