Results 11 to 20 of about 216,555 (260)

MicroRNA 200b promotes mesenchymal-to-epithelial transition in anaplastic thyroid carcinoma. [PDF]

Oncol Lett, 2020
Anaplastic thyroid cancer (ATC) remains a cancer with one of the worst prognoses, despite novel targeted therapies. The median survival rate has not improved for decades. Epithelial-to-mesenchymal transition (EMT) is a crucial step in physiological processes and in cancer progression, but the underlying mechanisms are not yet fully understood.
Tamagawa S, Enomoto K, Gunduz E, Gunduz M, Sato F, Uchino S, Muragaki Y, Hotomi M.   +7 more
europepmc   +4 more sources

Perinuclear mitochondrial clustering for mesenchymal-to-epithelial transition in pluripotency induction. [PDF]

Stem Cell Reports
Remodeled mitochondria are characteristic of pluripotent stem cells. However, a role for mitochondrial movement and distribution in pluripotency remains unknown. Here, we show that mitochondrial retrograde transport-mediated perinuclear clustering via dynein complex occurs at the early phase of pluripotency induction.
Xiang G, Liu Z, Yuan Z, Ying Z, Ding Y, Lin D, Qin H, Dong S, Zhou S, Yuan H, Xie W, Zheng Z, Chen Y, Li L, Long Q, Yang L, Wu Y, Chen K, Bao F, Huang Y, Li W, Wang J, Liu Y, Qin D, Liu X.   +24 more
europepmc   +3 more sources

On the role of mechanics in driving mesenchymal-to-epithelial transitions [PDF]

Seminars in Cell & Developmental Biology, 2017
The mesenchymal-to-epithelial transition (MET) is an intrinsically mechanical process describing a multi-step progression where autonomous mesenchymal cells gradually become tightly linked, polarized epithelial cells. METs are fundamental to a wide range of biological processes, including the evolution of multicellular organisms, generation of primary ...
Hye Young Kim, Timothy R. Jackson, Lance A. Davidson   +2 more
openaire   +2 more sources

The Transcription Factor Elf3 Is Essential for a Successful Mesenchymal to Epithelial Transition. [PDF]

Cells, 2019
The epithelial to mesenchymal transition (EMT) and the mesenchymal to epithelial transition (MET) are two critical biological processes that are involved in both physiological events such as embryogenesis and development and also pathological events such as tumorigenesis.
Sengez B, Aygün I, Shehwana H, Toyran N, Tercan Avci S, Konu O, Stemmler MP, Alotaibi H, Alotaibi H.   +8 more
europepmc   +7 more sources

Mesenchymal-to-epithelial transition of perivascular cells contributes to endometrial re-epithelialization. [PDF]

Nat Commun
Endometrial regeneration is essential for reproductive cycles and pregnancies, allowing the endometrium to undergo estrogen-driven repair, growth, and renewal after menstruation and parturition. Epithelial cells lining the uterine cavity undergo apoptosis during estrous cycles, and remnant cells can quickly restore this lining through a process known ...
Li SY, Whiteside S, Li B, Sun X, DeFalco T.   +4 more
europepmc   +3 more sources

Regulation of mesenchymal‐to‐epithelial transition by PARAXIS during somitogenesis [PDF]

Developmental Dynamics, 2013
Background: Dynamic alterations in cell shape, migration, and adhesion play a central role in tissue morphogenesis during embryonic development and congenital disease. The mesenchymal‐to‐epithelial transition that occurs during vertebrate somitogenesis is required for proper patterning of the axial musculoskeletal system.
Megan, Rowton, Pilar, Ramos, Douglas M, Anderson, Jerry M, Rhee, Heather E, Cunliffe, Alan, Rawls   +5 more
openaire   +2 more sources

Mesenchymal-to-epithelial transitions require tissue-specific interactions with distinct laminins [PDF]

Journal of Cell Biology, 2021
Mesenchymal-to-epithelial transition (MET) converts cells from migratory mesenchymal to polarized epithelial states. Despite its importance for both normal and pathological processes, very little is known about the regulation of MET in vivo. Here we exploit midgut morphogenesis in Drosophila melanogaster to investigate the mechanisms underlying MET. We
Ioanna Pitsidianaki, Jason Morgan, Jamie Adams, Kyra Campbell   +3 more
openaire   +3 more sources

p53 Counteracts reprogramming by inhibiting mesenchymal-to-epithelial transition [PDF]

Cell Death & Differentiation, 2012
The process of somatic cell reprogramming is gaining increasing interest as reprogrammed cells are considered to hold a great therapeutic potential. However, with current technologies this process is relatively inefficient. Recent studies reported that inhibition of the p53 tumor suppressor profoundly facilitates reprogramming and attributed this ...
R, Brosh, Y, Assia-Alroy, A, Molchadsky, C, Bornstein, E, Dekel, S, Madar, Y, Shetzer, N, Rivlin, N, Goldfinger, R, Sarig, V, Rotter   +10 more
openaire   +2 more sources

Epithelial elements in superficial angiomyxomas: mimicry of adnexal development, and mesenchymal-to-epithelial transition. [PDF]

Histopathology
AimsA subset of superficial angiomyxomas contains epithelial elements. Rarely, especially in Carney's complex patients, arborizing adnexal proliferations are present, with some authors proposing that they could be authentic adnexal neoplasms. Our aim was to determine if the epithelial elements are trapped adnexal epithelium, epithelial outgrowths ...
Monteagudo C, Terrádez L, Alvarez E, Masiá P, Espino M, Ortega M.   +5 more
europepmc   +5 more sources

Transdifferentiation and mesenchymal‐to‐epithelial transition during regeneration in Demospongiae (Porifera) [PDF]

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, 2019
Abstract Origin and early evolution of regeneration mechanisms remain among the most pressing questions in animal regeneration biology. Porifera have exceptional regenerative capacities and, as early Metazoan lineage, are a promising model for studying evolutionary aspects of regeneration.
Alexander V. Ereskovsky, Daria B. Tokina, Danial M. Saidov, Stephen Baghdiguian, Emilie Le Goff, Andrey I. Lavrov   +5 more
openaire   +4 more sources