Results 21 to 30 of about 216,555 (260)

Wnt is necessary for mesenchymal to epithelial transition in colorectal cancer cells [PDF]

Developmental Dynamics, 2017
Background: Metastasis underlies most colorectal cancer mortality. Cancer cells spread through the body as single cells or small clusters of cells that have an invasive, mesenchymal, nonproliferative phenotype. At the secondary site, they revert to a proliferative “tumor constructing” epithelial phenotype to rebuild a tumor.
Renate H.M. Schwab, Nancy Amin, Dustin J. Flanagan, Timothy M. Johanson, Toby J. Phesse, Elizabeth Vincan   +5 more
openaire   +4 more sources

Chibby1 knockdown promotes mesenchymal-to-epithelial transition-like changes [PDF]

Cell Cycle, 2017
Chibby1 (Cby1) was originally isolated as a binding partner for β-catenin, a dual function protein in cell-cell adhesion and in canonical Wnt signaling. The canonical Wnt/β-catenin pathway is dysregulated in various diseases including cancer, most notably of the gastrointestinal origin.
Victoria, Fischer, Michael, Wong, Feng-Qian, Li, Ken-Ichi, Takemaru   +3 more
openaire   +2 more sources

A reappraisal of mesenchymal-to-epithelial transition within the endometrium [PDF]

, 2021
A controversial topic, mesenchymal-epithelial transition (MET) is thought to be a mechanism involved in regeneration of the uterine epithelial layer following pregnancy and menstruation. Little is known about this process though, requiring further exploration.
openaire   +2 more sources

Epithelial-to-mesenchymal and mesenchymal-to-epithelial transitions in the colon

World Journal of Gastroenterology, 2012
Epithelial-to-mesenchymal and mesenchymal-to-epithelial transitions are well established biological events which have an important role in not just normal tissue and organ development, but in the pathogenesis of diseases. Increasing evidence has established their presence in the human colon during colorectal carcinogenesis and cancer invasion, chronic ...
Ferenc, Sipos, Orsolya, Galamb
openaire   +2 more sources

Understanding the relationship between circulating platelets and epithelial to mesenchymal transition – a step towards in discovering new epithelial ovarian cancer targeted therapies [PDF]

Romanian Medical Journal, 2022
In the last decades understanding the relationship between the circulating platelets and the biological aggressivity of ovarian cancer gave the opportunity to researchers to introduce new therapeutic lines in ovarian cancer patients with promising ...
Irina Balescu, Nicoale Bacalbasa, Iulian Brezean, Claudia Stoica, Cezar Laurentiu Tomescu, Cristina Martac, Andrei Voichitoiu, Bogdan Gaspar   +7 more
doaj   +1 more source

Single-cell transcriptome sequencing–based analysis: probing the mechanisms of glycoprotein NMB regulation of epithelial cells involved in silicosis

Particle and Fibre Toxicology, 2023
Chronic exposure to silica can lead to silicosis, one of the most serious occupational lung diseases worldwide, for which there is a lack of effective therapeutic drugs and tools.
Shaoqi Yang, Yuheng Sun, Min Long, Xinbei Zhou, Mengqin Yuan, Liliang Yang, Wei Luo, Yusi Cheng, Xinxin Zhang, Wei Jiang, Jie Chao   +10 more
doaj   +1 more source

H19 Functions as a Competing Endogenous RNA to Regulate EMT by Sponging miR-130a-3p in Glioma

Cellular Physiology and Biochemistry, 2018
Background/Aims: Glioma is one of the most devasting tumors and confers dismal prognosis. Long noncoding RNAs(lncRNAs) have emerged as important regulators in various tumors including glioma. A classic lncRNA-H19, which is found to be highly expressed in
Qi Hu, Jianxing Yin, Ailiang Zeng, Xin Jin, Zhuoran Zhang, Wei Yan, Yongping You   +6 more
doaj   +1 more source

Mesenchymal Stromal Cells Epithelial Transition Induced by Renal Tubular Cells-Derived Extracellular Vesicles. [PDF]

PLoS ONE, 2016
Mesenchymal-epithelial interactions play an important role in renal tubular morphogenesis and in maintaining the structure of the kidney. The aim of this study was to investigate whether extracellular vesicles (EVs) produced by human renal proximal ...
Giulia Chiabotto, Stefania Bruno, Federica Collino, Giovanni Camussi   +3 more
doaj   +1 more source

Crif1 is Required for Proper Mesenchymal to Epithelial Transition

Cumhuriyet Science Journal, 2022
The epithelial to mesenchymal and the mesenchymal to epithelial transitions (EMT and MET) are fundamental developmental processes required for shaping the embryo but are also hijacked by cancer cells during metastasis. The regulation of EMT is very well studied, and major regulators have been identified. A similar understanding of the regulation of MET
openaire   +3 more sources

High expression of forkhead box protein C2 is associated with aggressive phenotypes and poor prognosis in clinical hepatocellular carcinoma

BMC Cancer, 2018
Background Hepatocellular carcinoma (HCC) is one of the major causes of tumor death; thus, the identification of markers related to its diagnosis and prognosis is critical. Previous studies have revealed that epithelial-to-mesenchymal transition (EMT) is
Yuki Shimoda, Yasunari Ubukata, Tadashi Handa, Takehiko Yokobori, Takayoshi Watanabe, Dolgormaa Gantumur, Kei Hagiwara, Takahiro Yamanaka, Mariko Tsukagoshi, Takamichi Igarashi, Akira Watanabe, Norio Kubo, Kenichiro Araki, Norifumi Harimoto, Ayaka Katayama, Toshiaki Hikino, Takaaki Sano, Kyoichi Ogata, Hiroyuki Kuwano, Ken Shirabe, Tetsunari Oyama   +20 more
doaj   +1 more source