Results 121 to 130 of about 144,814 (311)

The Cellular and Physiological Basis for Lung Repair and Regeneration: Past, Present, and Future. [PDF]

, 2020
The respiratory system, which includes the trachea, airways, and distal alveoli, is a complex multi-cellular organ that intimately links with the cardiovascular system to accomplish gas exchange.
Basil, Maria C, Chapman, Hal A, Engler, Anna E, Guo, Minzhe, Herriges, Michael J, Kathiriya, Jaymin J, Katzen, Jeremy, Kotton, Darrell N, Morrisey, Edward E, Rock, Jason R, Snoeck, Hans-Willem, Vunjak-Novakovic, Gordana, Whitsett, Jeffrey A, Windmueller, Rebecca, Ysasi, Alexandra B, Zacharias, William J   +15 more
core   +1 more source

Adipose tissue derived mesenchymal stem cell transplantation in the treatment of ischemia/reperfusion induced acute kidney injury in rats. Application route and therapeutic window [PDF]

, 2018
Betânia Souza Monteiro, Bianka Souza dos Santos, Bruna Lopes de Almeida, Emy Hiura, Wagner Alexey Back Fiorio, Gisele Pereira Valdetaro, Dariele Vieira Gonçalves, Caroline Saraiva Silva, Tatiana Champion, Daniela Campagnol   +9 more
openalex   +1 more source

FAPα+ Macrophages Orchestrate Immune Evasion in Multiple Myeloma by Dual Regulation of PD‐L1 and T Cell Senescence

Advanced Science, EarlyView.
ABSTRACT Multiple myeloma (MM) is a hematologic malignancy driven by clonal expansion of malignant plasma cells. Despite the long‐term disease control achieved with immunotherapies in some patients, treatment resistance remains a major cause of disease relapse.
Huiyao Gu, Zhenfeng Dai, Xi Huang, Enfan Zhang, Xinyuan Dai, Haoguang Chen, Wen Cao, Jinna Zhang, Yifan Hou, Haimeng Yan, Yang Yang, Li Yang, Yi Li, Wenlong Lin, Zhen Cai, Jingsong He   +15 more
wiley   +1 more source

Genetically engineered BMSCs promote dopamine secretion and ameliorate motor dysfunction in a Parkinson’s disease rat model

Scientific Reports
Regenerative therapy based on mesenchymal stem cells (MSCs) is regarded as a promising strategy for treating Parkinson’s disease (PD). Previous studies have shown that mesenchymal stem cell transplantation has the potential to treat Parkinson’s disease ...
Chunjing Wang, Yang Liu, Junyan Chang, Yiqin He, Pan Yang, Jingjing Fu, Wanying Du, Caiyun Ma, Gaofeng Liu, Yu Guo, Changqing Liu   +10 more
doaj   +1 more source

Stochastic Nanoscale Biophysical Cues as a Basis for the Induction of Glioblastoma‐Like Transcriptional Programs in Astrocytes

Advanced Science, EarlyView.
Stochastic nanoscale physical cues induce glioblastoma (GBM)‐associated transcriptional traits in naïve astrocytes leading to spontaneous formation of spheroids. Cells within spheroids express activated‐MMP2 and a differential gene expression pattern involving P53 and NOTCH3, providing evidence for a role for changes in brain topography, as observed in
Laurent Starck, Tobias Butelmann, Sabrina Hogan, Melika Sarem, Bernd Heimrich, Ritwick Sawarkar, Marie‐Françoise Ritz, Gregor Hutter, V. Prasad Shastri   +8 more
wiley   +1 more source

A multicenter experience using adipose-derived mesenchymal stem cell therapy for cats with chronic, non-responsive gingivostomatitis. [PDF]

, 2020
BackgroundThe ability of mesenchymal stem cells (MSCs) to modulate immune responses inspired a series of clinical trials addressing oral mucosal inflammation.
Arzi, Boaz, Battig, Jean, Borjesson, Dori L, Clark, Kaitlin C, Delatorre, Ubaldo, Fiani, Nadine, Fulton, Amy, Lommer, Milinda J, Loscar, Megan R, Peralta, Santiago, Taechangam, Nopmanee, Vapniarsky, Natalia, Walker, Naomi J   +12 more
core   +1 more source

Positive Feedback Loop of Histone Lactylation‐Driven HNRNPC Promotes Autophagy to Confer Pancreatic Ductal Adenocarcinoma Gemcitabine Resistance

Advanced Science, EarlyView.
Histone 3 lysine18 lactylation (H3K18la) drives heterogeneous nuclear ribonucleoprotein C (HNRNPC) overexpression, activating autophagy to mediate gemcitabine resistance by stabilizing TNF receptor‐associated factor 6 (TRAF6) mRNA. Concurrently, HNRNPC stabilizes aldehyde dehydrogenase 1 family member A3 (ALDH1A3) mRNA, which enhances glycolysis and ...
Xi‐Tai Huang, Jiao Chen, En‐Liang Zhu, Ming‐Jian Ma, Yang‐Yin‐Hui Yu, Ying‐Qin Zhu, Jing‐Yuan Ye, Jin‐Zhao Xie, Zi‐Yi Zhao, Xiao‐Yu Yin   +9 more
wiley   +1 more source

Novel Vascularized Human Liver Organoids for Modeling Alcohol‐Induced Liver Injury and Developing Hepatoprotective Therapy

Advanced Science, EarlyView.
This study successfully engineered vascularized liver organoids (3HLOs) by co‐culturing human reprogrammed hepatocyte‐like cells (hrHLs) with human umbilical vein endothelial cells (HUVECs) and human umbilical mesenchymal stem cells (HUMSCs). Upon implantation, the 3HLOs established functional vascular anastomosis with the host circulation and ...
Kangdi Yang, Xiayan Chu, Xuerui Wang, Wenkun Zhang, Jinnuo Lu, Chuting Xu, Shoucheng Hu, Guoyu Pan, Chih‐Tsung Yang, Xiaohui Zhang, Shaojin Li, Zhaobin Guo, Hanyang Liu, Guangbo Ge   +13 more
wiley   +1 more source

Chondrogenic potential of human articular chondrocytes and skeletal stem cells: a comparative study

, 2014
Regenerative medicine strategies have increasingly focused on skeletal stem cells (SSCs), in response to concerns such as donor site morbidity, dedifferentiation and limited lifespan associated with the use of articular chondrocytes for cartilage repair.
Li, Siwei, Oreffo, Richard O.C., Sengers, Bram G., Tare, Rahul S.   +3 more
core   +1 more source

Peripheral Transplantation of Mesenchymal Stem Cells at Sepsis Convalescence Improves Cognitive Function of Sepsis Surviving Mice [PDF]

, 2022
Longjiao Tan, Yong Cheng, Hui Wang, Jianbin Tong, Xian Qin   +4 more
openalex   +1 more source