Results 131 to 140 of about 421,152 (353)

Controversies regarding transplantation of mesenchymal stem cells

World Journal of Transplantation
Mesenchymal stem cells (MSCs) have tantalized regenerative medicine with their therapeutic potential, yet a cloud of controversies looms over their clinical transplantation. This comprehensive review navigates the intricate landscape of MSC controversies, drawing upon 15 years of clinical experience and research.
Velikova, Tsvetelina, Dekova, Tereza, Miteva, Dimitrina Georgieva   +2 more
openaire   +2 more sources

3D‐Printed Corneal Substitutes: Materials, Fabrication, and Preclinical Progress

Advanced Materials Technologies, EarlyView.
Successful clinical translation of 3D‐printed corneal substitutes relies on the interplay between the bioink properties, cellular component, and the fabrication process. These factors influence the critical properties of the construct, including optical transparency, mechanical stability, suture retention, that ultimately govern long‐term stromal ...
Shadi Moshayedi, Ashley Vazquez, Alexander J. Choi, Dimitrios Karamichos, Jayoung Kim   +4 more
wiley   +1 more source

Mesenchymal stem cell grafts promote oligodendroglial differentiation after spinal cord injury [PDF]

, 2012
Transplantation of MSC into the acute injured spinal cord is sufficient to enhance oligodendroglial differentiation of endogenous spinal cord progenitor cells up to one month post-injury.
Bründl, Johannes
core   +1 more source

Magnetic cell delivery for the regeneration of musculoskeletal and neural tissues

Regenerative Therapy, 2018
Magnetic targeting is a cell delivery system using the magnetic labeling of cells and the magnetic field; it has been developed for minimally invasive cell transplantation.
Naosuke Kamei, Nobuo Adachi, Mitsuo Ochi
doaj   +1 more source

Therapeutic Use of Stem Cell Transplantation for Cell Replacement or Cytoprotective Effect of Microvesicle Released from Mesenchymal Stem Cell

Molecules and Cells, 2014
Idiopathic pulmonary fibrosis (IPF) is the most common and severe type of idiopathic interstitial pneumonias (IIP), and which is currently no method was developed to restore normal structure and function.
Moonhwan Choi, Taehyun Ban, T. Rhim
semanticscholar   +1 more source

MASH Background Confers Enhanced Disease Susceptibility and Acetaminophen Toxicity in iPSC‐Derived Liver Organoids

Advanced Science, EarlyView.
This work establishes a novel method for generating multicellular liver organoids from control and MASH donor iPSCs. The model recapitulates several disease‐specific characteristics, with MASH donor‐derived organoids showing higher susceptibility. Lipidomic profiling of MASH organoids closely resembles MASH liver biopsies.
Ekta Minocha, Ashwani Kumar Gupta, Nate Schmidt, Richard M. Green, John G. Purdy, Jason A. Wertheim   +5 more
wiley   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

HUMAN MESENCHYMAL STEM CELLS AS A MODEL OF STUDY FOR NEW BIOMATERIALS IN BONE TISSUE REGENERATION [PDF]

, 2012
The reconstruction of large bone segments remains a critical clinical problem in the case of extensive bone loss due to traumatic or pathological events. Due to its ideal biocompatibility and osteogenic properties, autologous bone is still considered the
Manfrini, Marco
core  

Mesenchymal Stem Cells Promote Oligodendroglial Differentiation in Hippocampal Slice Cultures [PDF]

, 2009
We have previously shown that soluble factors derived from mesenchymal stem cells (MSCs) induce oligodendrogenic fate and differentiation in adult rat neural progenitors (NPCs) in vitro.
Aigner, L., Götz, Magdalena, Blümcke, I., Berninger, Benedikt, Siebzehnrubl, Florian, Couillard-Despres, Sebastien, Bogdahn, Ulrich, Caioni, Massimiliano, Kandasamy, M., Pöhler, A.M., Couillard-Despres, S., Berninger, B., Weidner, N., Aigner, Ludwig, Götz, M., Siebzehnrubl, F.A., Bogdahn, U., Weidner, Norbert, Sandner, B., Poehler, Anne-Maria, Sandner, Beatrice, Goetz, Magdalena, Rivera, Francisco J., Caioni, M., Bluemcke, Ingmar, Siebzehnrubl, Florian A., Kandasamy, Mahesh, Rivera, F.J.   +27 more
core   +1 more source

Disruption of the SNRPF–DDX24–E2F4 Feedback Loop Uncouples Splicing and Transcriptional Regulation to Suppress Ovarian Cancer Progression

Advanced Science, EarlyView.
This study identifies SNRPF as a critical oncogenic driver in ovarian cancer. By regulating a self‐sustaining SNRPF–DDX24–E2F4 feedback loop through intron retention and nonsense‐mediated decay, SNRPF couples RNA splicing with transcriptional regulation to promote tumor progression.
Yingwei Li, Zhongshao Chen, Qianqian Gao, Yuehan Gao, Ning Yang   +4 more
wiley   +1 more source