Microphysiological Systems for Comorbidity Studies: Chronic Kidney Disease and Osteoarthritis
This review highlights the potential of organ‐on‐a‐chip systems for studying comorbidities, using chronic kidney disease (CKD) and osteoarthritis (OA) as examples. It summarizes recent advances in kidney‐on‐a‐chip and joint‐on‐a‐chip models and discusses their current and potential application in investigating CKD, OA, and CKD‐OA comorbidity, aiming to
Mingying Han+7 more
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Therapeutic Potential of Mesenchymal Stem Cells in Stroke Treatment. [PDF]
Choudhery MS+3 more
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Human mesenchymal stem cells modulate allogeneic immune cell responses [PDF]
Sudeepta Aggarwal, Mark F. Pittenger
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Engineered 3D‐Cad/IL6‐MSC, developed through synergistic hE/N‐cad‐Fc and IL‐6 preconditioning, show remarkable therapeutic potential for systemic sclerosis. These engineered MSC aggregates reduce pathogenic inflammatory cell infiltration and restore immune balance among CD4+ T‐cell populations, offering a promising approach to optimize MSC based ...
Yue Zhang+11 more
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Mesenchymal Stem Cells and Their Potential as Cardiac Therapeutics [PDF]
Mark F. Pittenger, Bradley J. Martin
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Effect of Nanoparticle Rigidity on the Interaction of Stromal Membrane Particles with Leukemia Cells
Cell membrane nanoparticles made with stromal cells are prepared and used to target leukemia cells. Deposition of the cell membrane onto rigid silica cores leads to increased uptake both in leukemia cell lines and primary cells from patients. These results show that nanoparticle rigidity affects the interaction between cell membrane nanoparticles and ...
Sander de Weerd+8 more
wiley +1 more source
Mesenchymal stem cells in the bone marrow microenvironment: a double-edged sword for AML. [PDF]
Saadh MJ+7 more
europepmc +1 more source
Adult mesenchymal stem cells: characterization, differentiation, and application in cell and gene therapy [PDF]
Dolores Baksh, Lin Song, Rocky S. Tuan
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Animal‐Free Setup of a 3D Mature Adipocyte‐Macrophage Co‐Culture to Induce Inflammation In Vitro
A completely animal‐free 3D co‐culture is developed using human fat cells and immune cells. Animal‐based materials are replaced with gellan gum hydrogel and a serum‐free medium. Immune cells are effectively activated, producing specific inflammatory signals.
Sophia Nowakowski+3 more
wiley +1 more source
Progress in the application of mesenchymal stem cells to attenuate apoptosis in diabetic kidney disease. [PDF]
Nie P, Qin W, Nie WC, Li B.
europepmc +1 more source