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Mesenchymal Stromal Cells (MSC)
2016Mesenchymal stem or stromal cells (MSC) are plastic-adherent fibroblast-like cells that can readily be isolated from various tissues and expanded in vitro. Per definitionem, they are able to differentiate into bone, cartilage and adipose tissue. In the last 15 years, a huge number of different preparative protocols have been developed to yield MSC-like
Patrick Wuchter +2 more
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Immunosuppressive Properties of Mesenchymal Stromal Cells
2012The main interest in mesenchymal stromal cells (MSCs) is correlated with their ability to suppress the proliferation of T lymphocytes induced by mitogenic agents and alloantigens which regulate the transplantation rejection. Moreover, MSCs are resistant to the CD8+ T lymphocyte cytotoxicity, they are able to inhibit the differentiation of dendritic ...
LANZA, Francesco +4 more
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Mesenchymal Stromal Cell Therapy
Transplantation, 2018Few medical advancements have captivated public interest as much as stem cell therapies. In fact, one of the original stem cell therapies was described in this very journal nearly 50 years ago1,2: the mesenchymal stem cell. Now known as mesenchymal stromal cells (MSCs),3 a more appropriate name due to their limited capacity to differentiate into ...
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Therapeutic applications of mesenchymal stromal cells
Seminars in Cell & Developmental Biology, 2007Mesenchymal stromal cells (MSC) are multipotent cells that can be derived from many different organs and tissues. They have been demonstrated to play a role in tissue repair and regeneration in both preclinical and clinical studies. They also have remarkable immunosuppressive properties.
Brooke, Gary +12 more
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Mesenchymal Stem/Stromal Cells: MESENCHYMAL STEM/STROMAL CELLS
Cytotherapy, 2023E. Heyman +3 more
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Immunomodulatory properties of mesenchymal stromal cells
Blood, 2007Abstract Mesenchymal stem cells (MSCs) are multipotential nonhematopoietic progenitor cells capable of differentiating into multiple lineages of the mesenchyme. MSCs have emerged as a promising therapeutic modality for tissue regeneration and repair.
Alma J, Nauta, Willem E, Fibbe
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Mesenchymal stromal cells and rheumatic disorders
Immunology Letters, 2015Mesenchymal stromal cells (MSC), often incorrectly called stem cells, have been the intense focus of in vitro studies and animal models of rheumatic and other diseases over more than a decade. Despite multiple plausible mechanisms of action and a plethora of positive in vivo animal studies, few randomised controlled clinical trials have demonstrated ...
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Immunomodulation by Multipotent Mesenchymal Stromal Cells
Transplantation, 2007Multipotent mesenchymal stromal cells (MSC) are currently under intense investigation to determine their role in cellular therapy. They are a rare subset of cells, but are easy to isolate and possess an extensive proliferative potential. MSC differentiate into cell types of mesenchymal and nonmesenchymal lineages, providing a promising tool for tissue ...
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Integrative oncology: Addressing the global challenges of cancer prevention and treatment
Ca-A Cancer Journal for Clinicians, 2022Jun J Mao,, Msce +2 more
exaly
Mesenchymal Stem/Stromal Cells: ROUTE-DEPENDENT MECHANISMS OF MESENCHYMAL STROMAL CELL THERAPY
Cytotherapy, 2023D. Zheng, T. Bhuvan, N. Payne, T. Heng
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