Results 51 to 60 of about 574,783 (292)

The Adaptive Composite Block-Structured Grid Calculation of the Gas-Dynamic Characteristics of an Aircraft Moving in a Gas Environment

open access: yesMathematics, 2022
This paper considers the problem associated with the numerical simulation of the interaction between the cocurrent stream occurring near a monoblock moving in the gas medium and solid fuel combustion products flowing from a solid fuel rocket engine (SFRE)
Victor V. Kuzenov   +2 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

A Level Set-Based Actuator Disc Model for Turbine Realignment in Wind Farm Simulation: Meshing, Convergence and Applications

open access: yesEnergies, 2022
We present a novel meshing and simulation approach for wind farms, featuring realignment and mesh adaptation. The turbines are modeled with actuator discs, which are discretized by means of an adaptation process to represent a level set function.
Abel Gargallo-Peiró   +3 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

POD-Kriging Reduced Method's Application in Tandem Cylinders' Flow [PDF]

open access: yesXibei Gongye Daxue Xuebao, 2018
The configuration of Tandem Cylinders is a typical one in researching noise and interactions between different components, where the distance-diameter ratio is a very significant parameter with which the flow form varies a lot.

doaj   +1 more source

Adaptive Physics-Based Non-Rigid Registration for Immersive Image-Guided Neuronavigation Systems

open access: yesFrontiers in Digital Health, 2021
Objective: In image-guided neurosurgery, co-registered preoperative anatomical, functional, and diffusion tensor imaging can be used to facilitate a safe resection of brain tumors in eloquent areas of the brain. However, the brain deforms during surgery,
Fotis Drakopoulos   +15 more
doaj   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

open access: yesFEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui   +10 more
wiley   +1 more source

WingMesh: A Matlab-Based Application for Finite Element Modeling of Insect Wings

open access: yesInsects, 2020
The finite element (FE) method is one of the most widely used numerical techniques for the simulation of the mechanical behavior of engineering and biological objects.
Shahab Eshghi   +4 more
doaj   +1 more source

Research on the application of time shifting aeromagnetic method in detecting coal mine burning areas

open access: yesGong-kuang zidonghua, 2023
The spontaneous combustion of coal seams leads to the formation of magnetic minerals in the overlying strata, exhibiting high magnetic anomaly features, providing a physical prerequisite for the magnetic method to detect the burning area.
YU Yongning   +5 more
doaj   +1 more source

Examples of finite element mesh generation using SDRC IDEAS [PDF]

open access: yes, 1990
IDEAS (Integrated Design Engineering Analysis Software) offers a comprehensive package for mechanical design engineers. Due to its multifaceted capabilities, however, it can be manipulated to serve the needs of electrical engineers, also.
Volakis, John L., Zapp, John
core   +1 more source

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