Results 21 to 30 of about 4,709 (265)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Jixie chuandong, 2017 The radial deformation is one of the important parameters that affect meshing characteristic and the life of flexspline in harmonic reducer. Based on envelope meshing theory of harmonic drive,the influence of radial deformation on meshing characteristic ...
Zhang Liyong +5 more
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Journal of Mechanical Engineering, 2023 Based on the results obtained in the previous research, the values of meshing characteristics of profile shifted quasi-involute arc-tooth-trace gears is calculated.
Tkach Pavlo +5 more
doaj +1 more source
FEBS Open Bio, EarlyView.ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui +10 more
wiley +1 more source
Jixie chuandong, 2012 According to characteristic of point-line meshing gear and basic law of meshing,a common no meshing backlash equation of point-line meshing gear,a calculation formula about least modification coefficient of straight tooth point-line meshing gear and ...
丁军, 黄海, 厉海祥, 周晓菊
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Clinical characteristics of patients with inguinal hernia mesh migration into the bladder
IJU Case Reports, 2022 IntroductionWe report two cases of mesh migration into the bladder after inguinal hernia surgery.Case presentationIn the first case, a 48‐year‐old woman who underwent right internal inguinal hernia repair, 18 months prior, presented with pollakiuria and microscopic hematuria that was resistant to antibiotics.
Takahiro Akimoto +5 more
openaire +3 more sources
Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
FEBS Open Bio, EarlyView.We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Study on the Meshing Force and Meshing Rigidity of Cylinder Sine Oscillation Tooth Transmission
Jixie chuandong, 2015 Based on the hypothesis of stretch small distortion and distortion congruity,the model and algorithm of meshing force analysis under theoretical conditions are given.According to the Hertz theory and geometric relation of meshing pair,the meshing ...
Zeng Yunyun, Yuan Xinmei, Zhou Sizhu
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