Results 41 to 50 of about 70,412 (305)
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Study on the Coupling Relationship between Wear and Dynamics in Planetary Gear Systems
Machines, 2023 The occurrence of wear is hard to avoid in gear systems because of their transmission principle. Wear will lead to a deviation of the system’s performance from the design objectives or even failure.
Jun Chen, Ning Dong, Jiahua Min
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Study on the Wear Performance of Spiroid Worm Drive with Steel–Steel Meshing
MachinesWorm drive belongs to the inclined plane transmission principle, and there is severe wear on the conjugate tooth surface. To reveal the wear mechanism and realize steel–steel meshing in the spiroid worm drive, the meshing performance model of conjugate ...
Yan Chen, Yun Pu, Yonghong Chen
doaj +1 more source
FEBS Open Bio, EarlyView.ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui +10 more
wiley +1 more source
Computerized Generation and Surface Deviation Correction of Ruled Surface for Face Gear Drives
Applied SciencesIn order to solve the problems of low efficiency and complex cutting tools in conventional face gear machining, this paper presents a machining method of ruled surface face gears with conical cutters and proposes a new pinion to correct deviation and its
Xianlong Peng, Yikai Wu
doaj +1 more source
Applied Sciences, 2022 In previous studies, the meshing force of a gear system is usually treated as being uniformly distributed for the convenience of analysis. In practical applications, however, it is nonuniformly distributed along the line of action due to machining errors,
Bohan Jin +3 more
doaj +1 more source
Investigating the Effect of Water Contamination on Gearbox Lubrication based on Motor Control Data from a Sensorless Drive [PDF]
, 2014 Water is one of the most significant destructive contaminations to lubricants which in turn lead to more power consumption and early damage to rotating machines.
Abusaad, Samieh +4 more
core
VoroCrust: Voronoi Meshing Without Clipping
, 2020 Polyhedral meshes are increasingly becoming an attractive option with particular advantages over traditional meshes for certain applications. What has been missing is a robust polyhedral meshing algorithm that can handle broad classes of domains ...
Abdelkader, Ahmed +6 more
core +1 more source
Mesh update techniques for free-surface flow solvers using spectral element method [PDF]
, 2007 This paper presents a novel mesh-update technique for unsteady free-surface Newtonian flows using spectral element method and relying on the arbitrary Lagrangian--Eulerian kinematic description for moving the grid.
A.A. Johnson +15 more
core +2 more sources