Results 41 to 50 of about 61,355 (334)

Outils pour l’identification des paramètres de raideur des robots à l’aide d’un logiciel de CAO [PDF]

, 2014
This report proposes a CAD-based approach for identification of the elasto-static parameters of the robotic manipulators. The main contributions are in the areas of virtual experiment planning and algorithmic data processing, which allows to obtain the ...
KLIMCHIK, Alexandr, PASHKEVICH, Anatol
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Isothermal Elasto-hydrodynamic Lubrication Analysis of the Roller Enveloping End Face Meshing Worm Drive

Jixie chuandong, 2022
Based on the transmission theory of single roller enveloping end face meshing worm drive and isothermal elastohydrodynamic lubrication theory， and considering the influence of surface wavy roughness， a numerical analysis method is adopted to analyze the ...
Xiaolong Wang, Honghui Liao
doaj  

Generation principle and meshing characteristics of conjugate-curve circular arc gears

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2015
The generation principle and meshing characteristics of conjugate-curve circular arc gears, which is proposed based on the theory of conjugate curves, are studied in this paper.
Dong LIANG, Bingkui CHEN, Yan'e GAO, Yongqing ZHANG   +3 more
doaj   +1 more source

3D mesh calculations for covariant density functional theory [PDF]

Progress of Theoretical and Experimental Physics, 2015
3D mesh calculations for covariant density functional theory Y. Tanimura1,5,∗, K. Hagino1,2,3, and H. Z. Liang4 1Department of Physics, Tohoku University, Sendai 980-8578, Japan 2Research Center for Electron Photon Science, Tohoku University, 1-2-1 Mikamine, Sendai 982-0826, Japan 3National Astronomical Observatory of Japan, 2-21-1 Osawa, Mitaka, Tokyo
Y. Tanimura, K. Hagino, H. Z. Liang
openaire   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Accuracy Improvement for Stiffness Modeling of Parallel Manipulators [PDF]

, 2009
The paper focuses on the accuracy improvement of stiffness models for parallel manipulators, which are employed in high-speed precision machining. It is based on the integrated methodology that combines analytical and numerical techniques and deals with ...
Chablat, Damien, Klimchik, Alexandr, Pashkevich, Anatoly, Wenger, Philippe   +3 more
core   +4 more sources

Approximate theory for radiation from mesh reflectors

Electronics Letters, 1988
Reconfigurable shaped reflector antennas have potential applications in satellite communications and satellite broadcasting. When a metallic mesh is employed pillowing occurs between the points at which the reflector is constrained. The letter describes an approximate theory to explain the behaviour, and results are obtained which are in good agreement
G.T. Poulton, H. Zhou, P.J.B. Clarricoats   +2 more
openaire   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source