Results 61 to 70 of about 17,772 (222)

A guide to neuromodulation in drug‐resistant epilepsy

Epileptic Disorders, EarlyView.
Abstract Neuromodulation is approved for the treatment of drug‐resistant epilepsy. It has been increasingly utilized over the past two decades with the approval of deep brain stimulation (DBS) and responsive neurostimulation (RNS) in addition to vagus nerve stimulation (VNS)—particularly in patients who are not deemed to be good resective surgical ...
Prachi Parikh, Irena Dolezawa, Manu Hegde, Lukas Imbach, Brian N. Lundstrom, Francesca Pizzo, Vikram R. Rao, Jaysingh Singh, Derek Southwell, Satsuke Watanabe, Birgit Frauscher   +10 more
wiley   +1 more source

Triple pathology in a patient with uncontrolled epilepsy: a case report

Journal of Medical Case Reports
Background Sturge–Weber syndrome is an uncommon neurocutaneous disorder with characteristic vascular lesions, leptomeningeal angiomas, and facial nevi. Seizureis the most prevalent neurological sign of Sturge–Weber syndrome and complications related to ...
Sara Ranji, Behnam Akbari, Melika Javani, Aidin Taghilou, Abbas Tafakhori, Saeideh Salehizadeh, Hoda Naghshineh   +6 more
doaj   +1 more source

Preoperative automated fibre quantification predicts postoperative seizure outcome in temporal lobe epilepsy [PDF]

, 2016
Approximately one in every two patients with pharmacoresistant temporal lobe epilepsy will not be rendered completely seizure-free after temporal lobe surgery. The reasons for this are unknown and are likely to be multifactorial.
Barker, GJ, Bonilha, L, Glenn, GR, Helpern, JA, Jensen, JH, Keller, SS, Kreilkamp, BAK, Richardson, MP, Wagner, J, Weber, B   +9 more
core   +2 more sources

Synchrotron‐generated microbeams as a radiosurgical alternative for drug‐resistant epilepsies: Proof of concept in a mouse model of mesiotemporal lobe epilepsy

Epilepsia, EarlyView.
Abstract Objective One‐third of patients with epilepsy, particularly those with mesial temporal lobe epilepsy (MTLE), remain resistant to medication. Resective surgery, the gold standard, is highly invasive and carries significant risks. Here, using a mouse model, we explored the potential of microbeam radiation therapy (MRT), a new technique based on ...
Loan Samalens, Camille Beets, Clothilde Courivaud, Sarvenaz Keshmiri, Jean‐François Adam, Paolo Pellicioli, Emmanuel Luc Barbier, Raphaël Serduc, Antoine Depaulis   +8 more
wiley   +1 more source

The typical features of mesial temporal lobe epilepsy with hippocampal sclerosis in children [PDF]

Romanian Journal of Neurology, 2012
Purpose. The aim of this study is to report on a group of 30 children with the diagnosis of mesial temporal lobe epilepsy (MTLE) and a magnetic resonance imaging (MRI) evidence of hippocampal sclerosis (HS), with special emphasis on electroclinical ...
Adriana Gabriela Albeanu, Sanda Magureanu, Lieven Lagae   +2 more
doaj   +1 more source

Freedon study: Real‐life outcomes of cenobamate in different lines of treatment

Epilepsia, EarlyView.
Abstract Objectives Cenobamate is an antiseizure medication (ASM) with proven effectiveness in individuals with highly refractory epilepsy. This study investigated the effectiveness and tolerability of cenobamate in different treatment lines and a less refractory setting. Methods This was a multicenter, retrospective, observational study.
Vicente Villanueva, José María Serratosa, Alejandro Fernández‐Cabrera, Manuel Toledo, Beatriz González‐Giráldez, José C. Estevez, Juan Jesús Rodríguez Uranga, Maria Machio Castelló, Maria Dolores Castro‐Vilanova, Juan José Poza, Xiana Rodríguez‐Osorio, Kevin G. Hampel, Elena Fonseca, Francisco Javier López‐González, Mercedes Garcés, Laura Abraira, Jordi Ciurans, Daniel Campos‐Fernández, Estevo Santamarina, Juan María Sanchez‐Caro, Lucas Iacampo, Julia Renau, Miguel Ángel García‐Quesada, Carla Anciones, María Isabel Chamorro, Iratxe Maestro, Pablo Cabezudo, Raquel Calle, Jesús Macarron, Beatriz Cabezas, María Carrasco, María López, Marta Marín, Rosa Querol, Belén Baena, Vanessa García‐Morales, Samuel López‐Maza, Álvaro Juiz, Blanca Mercedes‐Alvarez, Carla Amarante, Ana del Villar, Ascensión Castillo, Marta Rubio‐Roy, Javier Martinez‐Poles, Asier Gómez‐Ibáñez, Beatriz Parejo‐Carbonell, Anabelén Martínez Garcia, Ignacio Carrera, Pablo Iriarte, Fátima Romero‐Aguilera, on behalf of the Pharmacological Therapy Working group of the Spanish Epilepsy Society and Freedon Group   +50 more
wiley   +1 more source

Distinct thalamic functional connectivity and volume patterns across focal epilepsies in children: A multimodal neuroimaging study

Epilepsia, EarlyView.
Abstract Objective The thalamus is a key hub in seizure propagation, and its nuclei are emerging targets for neuromodulation. However, the contributions of individual nuclei to epileptic networks remain unclear, particularly in children, who are less studied than adults.
Xiyu Feng, Aswin Chari, Maria H. Eriksson, Freya Prentice, Xiaosong He, Hua Xie, Leigh Sepeta, M. Zubair Tahir, Jonathan D. Clayden, Martin M. Tisdall, Torsten Baldeweg, Rory J. Piper   +11 more
wiley   +1 more source

Clinical Characteristics of Mesial Temporal Lobe Epilepsy With Hippocampal Sclerosis and Temporal Lobe Epilepsies Due to Other Etiologies

Central Asian Journal of Medical Sciences, 2017
Objectives: This study compared the clinical characteristics of patients with mesial temporal lobe epilepsy with hippocampal sclerosis (mTLE-HS) to patients with temporal lobe epilepsy (TLE) due to other etiologies.
Amarjargal Myangaa, Tuvshinjargal Dashjamts, Tsagaankhuu Guntev, Tovuudorj Avirmed   +3 more
doaj   +1 more source

Correlação da intensidade do sinal em FLAIR e os níveis de mediadores inflamatórios no hipocampo de pacientes com epilepsia do lobo temporal e esclerose mesial temporal [PDF]

, 2011
We investigated a relationship between the FLAIR signal found in mesial temporal sclerosis (MTS) and inflammation. Twenty nine patients were selected through clinical and MRI analysis and submitted to cortico-amygdalo-hippocampectomy to seizure control ...
AMADO, Débora, CABOCLO, Luís Otávio Sales Ferreira, CANZIAN, Mauro, CARRETE JR., Henrique, CASTRO NETO, Eduardo Ferreira de, CAVALHEIRO, Esper Abrão, CENTENO, Ricardo Silva, HIGA, Elisa Mieko Suemitsu, NAFFAH- MAZZACORATTI, Maria da Graça, SANTIAGO, Joselita Ferreira Carvalho, VARELLA, Pedro Paulo Vasconcellos, YACUBIAN, Elza Márcia Targas   +11 more
core   +3 more sources

Insulin‐like growth factor 1 receptor correlates with verbal memory in ILAE type 2 hippocampal sclerosis

Epilepsia, EarlyView.
Abstract Objective Long‐term memory deficits are often seen in patients with temporal lobe epilepsy (TLE). Recently, studies showed that patients with hippocampal sclerosis (HS) type 2, which presents with severe neuron loss in CA1 only, performed within the normal range. However, up to 30% of HS type 2 cases have memory deficits.
Henrique Cruz, Amauri Batista de Oliveira‐Júnior, André Fernando Garcia Cortez, Ricardo Lutzky Saute, Ricardo Silva Centeno, Joao Norberto Stávale, Mirian Salvadori Bittar Guaranha, Elza Marcia Targas Yacubian, Esper Abrão Cavalheiro, Joao Pereira Leite, Jose Eduardo Peixoto‐Santos   +10 more
wiley   +1 more source