Results 81 to 90 of about 113,853 (284)

LGR4, Not LGR5, Enhances hPSC Hematopoiesis by Facilitating Mesoderm Induction via TGF-Beta Signaling Activation

Cell Reports, 2020
Summary: Attempts to generate functional blood cells from human pluripotent stem cells (hPSCs) remain largely unsuccessful, mainly due to the lack of understanding of the regulatory network of human hematopoiesis.
Yu Wang, Hongtao Wang, Jiaojiao Guo, Jie Gao, Mengge Wang, Meijuan Xia, Yuqi Wen, Pei Su, Ming Yang, Mingyao Liu, Lihong Shi, Tao Cheng, Wen Zhou, Jiaxi Zhou   +13 more
doaj  

Location, Location, Location: Signals in Muscle Specification

Journal of Developmental Biology, 2018
Muscles control body movement and locomotion, posture and body position and soft tissue support. Mesoderm derived cells gives rise to 700 unique muscles in humans as a result of well-orchestrated signaling and transcriptional networks in specific time ...
Chih-Ning Chang, Chrissa Kioussi
doaj   +1 more source

Cell motility driving mediolateral intercalation in explants of Xenopus laevis [PDF]

, 1992
In Xenopus, convergence and extension are produced by active intercalation of the deep mesodermal cells between one another along the mediolateral axis (mediolateral cell intercalation), to form a narrower, longer array.
Keller, Ray, Shih, John
core  

Neural crest induction in Xenopus: evidence for a two-signal model [PDF]

, 1998
We have investigated the molecular interactions underlying neural crest formation in Xenopus. Using chordin overexpression to antagonize endogenous BMP signaling in whole embryos and explants, we demonstrate that such inhibition alone is insufficient to ...
Bronner-Fraser, Marianne, LaBonne, Carole   +1 more
core  

Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease [PDF]

, 2009
The events that convert adherent epithelial cells into individual migratory cells that can invade the extracellular matrix are known collectively as epithelial-mesenchymal transition (EMT).
Akitaya, Alkhateeb, Andersson, Barrallo-Gimeno, Bertocchini, Chea, Ciruna, del Barrio, Dixon, Dottori, el Ghouzzi, Favier, Gans, Garcia-Castro, Giehl, Haraguchi, Hervé Acloque, Iwano, Johansson, Kalluri, Katherine Fishwick, Kitajima, Kos, Kwok, Liu, Liu, M. Angela Nieto, Manzanares, Marianne Bronner-Fraser, Martin, Mathieu, Meghan S. Adams, Moreno-Bueno, Nakagawa, Nakaya, Nieto, Peinado, Perea-Gomez, Perez-Pomares, Pijnenborg, Popperl, Sato, Sela-Donenfeld, Sela-Donenfeld, Selleck, Shah, Skromne, Tanimizu, Thiery, Varlet   +49 more
core   +3 more sources

Inhibition of Wnt activity induces heart formation from posterior mesoderm.

Genes & Development, 2001
In the chick, heart mesoderm is induced by signals from the anterior endoderm. Although BMP-2 is expressed in the anterior endoderm, BMP activity is necessary but not sufficient for heart formation.
M. Marvin, Giuliana Di Rocco, Aaron Gardiner, Sara M. Bush, A. Lassar   +4 more
semanticscholar   +1 more source

Stem/progenitor cells in the developing human lung

Journal of Pediatric and Neonatal Individualized Medicine, 2016
Human lungs are composed of more than 40 cell types. The lung is classified as a “conditionally renewing” tissue and is able of a quick response to cellular damage thanks to the presence of multiple stem/progenitor cells.
Daniela Fanni, Margherita Fanos, Clara Gerosa, Flaviana Cau, Erika Pisu, Peter Van Eyken, Rossano Ambu   +6 more
doaj   +1 more source

Sall4 regulates posterior trunk mesoderm development by promoting mesodermal gene expression and repressing neural genes in the mesoderm

Development
ABSTRACT The trunk axial skeleton develops from paraxial mesoderm cells. Our recent study demonstrated that conditional knockout of the stem cell factor Sall4 in mice by TCre caused tail truncation and a disorganized axial skeleton posterior to the lumbar level. Based on this phenotype, we hypothesized that, in addition to the previously
Matthew P. Pappas, Hiroko Kawakami, Dylan Corcoran, Katherine Q. Chen, Earl Parker Scott, Julia Wong, Micah D. Gearhart, Ryuichi Nishinakamura, Yasushi Nakagawa, Yasuhiko Kawakami   +9 more
openaire   +2 more sources

Adult-onset degeneration of adipose tissue in mice deficient for the Sox8 transcription factor

Journal of Lipid Research, 2009
Although the transcription factor Sox8 is broadly expressed during embryogenesis in developing ectodermal and mesodermal tissues, mice develop surprisingly normally in the absence of Sox8.
Sabine I.E. Guth, Katy Schmidt, Andreas Hess, Michael Wegner   +3 more
doaj  

Alternative Ways to Obtain Human Mesenchymal Stem Cells from Embryonic Stem Cells

Cells
Differentiation approaches to obtain mesenchymal stem cells (MSCs) have gradually developed over the last few decades. The problem is that different protocols give different MSC types, making further research difficult.
Nikita Onyanov, Olga Glazova, Nawar Sakr, Tatyana Krokunova, Julia Krupinova, Pavel Volchkov   +5 more
doaj   +1 more source