Results 81 to 90 of about 977,339 (281)

Poly(lactic‐co‐glycolic acid) Nanoparticles for IL‐12 Self‐Amplifying RNA Delivery in Glioblastoma Models

Advanced Functional Materials, EarlyView.
xxxx. ABSTRACT Glioblastoma (GBM) remains one of the most lethal brain cancers, with median survival rarely exceeding 15 months after diagnosis. Interleukin‐12 (IL‐12) is a potent immunostimulatory cytokine capable of reshaping the tumor microenvironment (TME), yet its clinical translation is hindered by systemic toxicity and short half‐life. RNA‐based
Fatima Hameedat, Johan Sebastian Lopez‐Parra, Willem M. H. Hoogaars, Emma Dijkstra, Cynthia Huang, Irafasha C. Casmil, Anna K. Blakney, Peter Olinga, Barbara Rothen‐Rutishauser, Hélder A. Santos, Alke Petri‐Fink, Flávia Sousa   +11 more
wiley   +1 more source

Implications on SUSY breaking mediation mechanisms from observing $B_s \to \mu^+ \mu^-$ and the muon $(g-2)$

, 2002
We consider $B_s \to \mu^+ \mu^-$ and the muon $(g-2)_\mu$ in various SUSY breaking mediation mechanisms. If the decay $B_s \to \mu^+ \mu^-$ is observed at Tevatron Run II with a branching ratio larger than $\sim 2 \times 10^{-8} $, the noscale ...
A. Pomarol, D. E. Kaplan, G. Isidori, G. F. Giudice, J. R. Ellis, L. Randall, N. Arkani-Hamed, P. Ko, R. Rattazzi, Seungwon Baek, T. Gherghetta, Wan Young Song, Z. Chacko, Z. Chacko   +13 more
core   +1 more source

Unraveling the Heterogeneity of Cargo Distribution in the Exogenous Association of Proteins With Extracellular Vesicles

Advanced Healthcare Materials, EarlyView.
We characterized the distribution of cargo proteins associated with extracellular vesicles using various exogenous loading methods. In all cases, single‐particle analysis revealed that the distribution of protein content per EV is heterogeneous, following an exponential decay function.
Karl Normak, Marcell Papp, Carolina Paganini, Andrea Zendrini, Paolo Bergese, Dorothea Pinotsi, Paolo Arosio   +6 more
wiley   +1 more source

The expression of renin-angiotensin system components in human carotid plaque [PDF]

Vojnosanitetski Pregled
Background/Aim. The renin-angiotensin system (RAS) is linked to the development of atherosclerosis (As), including its initiation and progression. Besides the well-known angio-tensin-converting enzyme (ACE), two newer RAS family members are related to ...
Kolaković Ana, Bundalo Maja, Đurić Tamara, Končar Igor, Stanković Aleksandra, Živković Maja   +5 more
doaj   +1 more source

Anti-competitiveness of Instant Messenger Tying by Microsoft [PDF]

In this paper, we theoretically analyze Microsoft's tying practice in the instant messenger market. Using a model that highlights distinct features of the instant messenger, which are different from the cases of the web browser and the media player, we ...
Bang, Se Hoon, Hwang, Sunjoo, Kim, Jaehong   +2 more
core  

The ANTARES Collaboration: Contributions to ICRC 2017 Part II: The multi-messenger program [PDF]

, 2017
Papers on the ANTARES multi-messenger program, prepared for the 35th International Cosmic Ray Conference (ICRC 2017, Busan, South Korea) by the ANTARES ...
Albert, A., André, M., Anghinolfi, M., ANTARES Collaboration, Anton, G., Ardid, M., Aubert, J. -J., Avgitas, T., Baret, B., Barrios-Martí, J., Basa, S., Belhorma, B., Bertin, V., Biagi, S., Bojaddaini, I. El, Bormuth, R., Bourret, S., Bouwhuis, M. C., Bruijn, R., Brunner, J., Brânzaş, H., Busto, J., Capone, A., Caramete, L., Carr, J., Celli, S., Chiarusi, T., Circella, M., Coelho, J. A. B., Coleiro, A., Coniglione, R., Costantini, H., Coyle, P., Creusot, A., De Bonis, G., de Jong, M., Deschamps, A., Di Palma, I., Distefano, C., Domi, A., Donzaud, C., Dornic, D., Drouhin, D., Díaz, A. F., Eberl, T., Elsässer, D., Enzenhöfer, A., Ettahiri, A., Fassi, F., Felis, I., Fusco, L. A., Gay, P., Giordano, V., Glotin, H., Graf, K., Grégoire, T., Hallmann, S., Heijboer, A. J., Hello, Y., Hernández-Rey, J. J., Hofestädt, J., Hugon, C., Hößl, J., Illuminati, G., James, C. W., Jongen, M., Kadler, M., Kalekin, O., Katz, U., Khayati, N. El, Kießling, D., Kouchner, A., Kreter, M., Kreykenbohm, I., Kulikovskiy, V., Lachaud, C., Lahmann, R., Lefèvre, D., Leonora, E., Lotze, M., Loucatos, S., Marcelin, M., Margiotta, A., Marinelli, A., Martínez-Mora, J. A., Mele, R., Melis, K., Michael, T., Migliozzi, P., Moursli, R. Cherkaoui El, Moussa, A., Navas, S., Nezri, E., Organokov, M., Pellegrino, C., Perrina, C., Piattelli, P., Popa, V., Pradier, T., Păvălaş, G. E., Quinn, L., Racca, C., Riccobene, G., Ruiz, R. Gracia, Saldaña, M., Salvadori, I., Samtleben, D. F. E., Sanguineti, M., Sapienza, P., Schüssler, F., Sieger, C., Spurio, M., Stolarczyk, Th., Sánchez-Losa, A., Taiuti, M., Tayalati, Y., Trovato, A., Turpin, D., Tönnis, C., Vallage, B., Van Elewyck, V., van Haren, H., Versari, F., Vivolo, D., Vizzoca, A., Wilms, J., Zornoza, J. D., Zúñiga, J.   +127 more
core   +1 more source

Geometrically Tunable Scaffold‐Free Muscle Bioconstructs for Treating Volumetric Muscle Loss

Advanced Healthcare Materials, EarlyView.
Volumetric muscle loss is associated with traumatic muscle resulting in permanent functional impairment. Mold‐based, scaffold‐free, high‐density muscle tissue bioconstructs are developed in customizable geometric shapes and sizes. The transplanted rectangular solid‐shaped muscle bioconstructs improved muscle force recovery and tissue regeneration in ...
Bugra Ayan, Gaoxian Chen, Ishita Jain, Sha Chen, Gladys Chiang, Caroline Hu, Renato Reyes, Beu P. Oropeza, Ngan F. Huang   +8 more
wiley   +1 more source

Search method for long-duration gravitational-wave transients from neutron stars

, 2011
We introduce a search method for a new class of gravitational-wave signals, namely long-duration O(hours - weeks) transients from spinning neutron stars. We discuss the astrophysical motivation from glitch relaxation models and we derive a rough estimate
Giampanis, Stefanos, Messenger, Chris, Prix, Reinhard   +2 more
core   +1 more source

SiO2‐CaOCME/Poly(Tetrahydrofuran)/Poly(Caprolactone) 3D‐Printed Scaffolds Drive Human‐Bone Marrow Stromal Cell Osteogenic Differentiation

Advanced Healthcare Materials, EarlyView.
3D printed hybrid scaffolds combining bioactive silica–calcium chemistry with elastic polymers guide human bone stem cells to form bone. The scaffolds support cell survival, organization, and invasion while releasing osteogenic ions. Together, architecture and composition drive bone‐specific gene expression, extracellular matrix organization, and ...
David R. Sory, Agathe C.M. Heyraud, Julian R. Jones, Sara M. Rankin   +3 more
wiley   +1 more source

Peptomer Linkers Enable Kinetic Control over Co‐Delivery of Multiple Chemotherapeutics

Advanced Healthcare Materials, EarlyView.
A key challenge in combinatorial chemotherapeutic drug delivery is independent control over release kinetics, especially with drugs of similar size and structure. Here, peptoid substitutions to proteolytically degradable peptides enabled the design of fast and slow‐releasing drug linkers.
Carolyn M. Watkins, Samuel L. Hallam, Mariah J. Austin, Adrianne M. Rosales   +3 more
wiley   +1 more source