Results 1 to 10 of about 303,389 (258)

Efficacy and Safety of Messenger RNA Vaccines [PDF]

Health Science Reports
Background and Aims The rapid development of mRNA vaccines has revolutionized infectious disease prevention and cancer immunotherapy. While their efficacy is well established, concerns about safety and immunopathological risks persist. This study aims to
Kesaobaka Batisani, David Chisompola
doaj   +2 more sources

Expression profile, clinical significance, and biological function of insulin-like growth factor 2 messenger RNA-binding proteins in non–small cell lung cancer

Tumor Biology, 2017
Insulin-like growth factor 2 messenger RNA-binding proteins have been described to associate with malignant process in many cancers. However, the role of insulin-like growth factor 2 messenger RNA-binding protein family has not been thoroughly elucidated
Run Shi, Xinnian Yu, Yajing Wang, Jing Sun, Qi Sun, Wenjie Xia, Gaochao Dong, Anpeng Wang, Zhaojia Gao, Feng Jiang, Lin Xu   +10 more
doaj   +2 more sources

Matrices Activated with Messenger RNA

Journal of Functional Biomaterials, 2023
Over two decades of preclinical and clinical experience have confirmed that gene therapy-activated matrices are potent tools for sustained gene modulation at the implantation area.
Raquel Martinez-Campelo, Marcos Garcia-Fuentes   +1 more
doaj   +1 more source

Hypertensive crisis following mRNA COVID-19 vaccination in adolescents: two case reports [PDF]

Childhood Kidney Diseases, 2022
In response to the global coronavirus disease 2019 (COVID-19) pandemic, vaccines were developed and approved quickly. However, numerous cardiovascular adverse events have been reported.
Myung Hyun Cho, Hae Il Cheong
doaj   +1 more source

Respiratory syncytial virus M2-1 protein associates non-specifically with viral messenger RNA and with specific cellular messenger RNA transcripts.

PLoS Pathogens, 2021
Respiratory syncytial virus (RSV) is a major cause of respiratory disease in infants and the elderly. RSV is a non-segmented negative strand RNA virus.
Molly R Braun, Sarah L Noton, Emmeline L Blanchard, Afzaal Shareef, Philip J Santangelo, W Evan Johnson, Rachel Fearns   +6 more
doaj   +1 more source

Rapid nuclear deadenylation of mammalian messenger RNA

iScience, 2023
Summary: Poly(A) tails protect RNAs from degradation and their deadenylation rates determine RNA stability. Although poly(A) tails are generated in the nucleus, deadenylation of tails has mostly been investigated within the cytoplasm.
Jonathan Alles, Ivano Legnini, Maddalena Pacelli, Nikolaus Rajewsky   +3 more
doaj   +1 more source

Construction of a circRNA-miRNA-mRNA Regulated Pathway Involved in EGFR-TKI Lung Adenocarcinoma Resistance

Technology in Cancer Research & Treatment, 2021
Objectives: Epidermal growth factor receptor-tyrosine kinase inhibitors are widely used for lung epidermal growth factor receptor-positive lung adenocarcinomas, but acquired resistance is inevitable.
Chenyue Dai MM, Bing Liu MD, Shaolei Li PhD, Yang Hong PhD, Jiahui Si PhD, Ying Xiong MSc, Nan Wu MD, Yuanyuan Ma PhD   +7 more
doaj   +1 more source

Real-Time Messenger RNA Dynamics in Bacillus subtilis

Frontiers in Microbiology, 2021
Messenger RNA molecules have been localized to different positions in cells and have been followed by time-lapse microscopy. We have used MS2-mVenus–labeled mRNA and single-particle tracking to obtain information on the dynamics of single-mRNA molecules ...
Laura Sattler, Peter L. Graumann
doaj   +1 more source

François Gros: from antibiotics to messenger RNA

Comptes Rendus Biologies, 2023
François Gros was a prominent French Molecular Biologist who made a major contribution to the discovery of messenger RNA in 1961. He pursued outstanding research on bacterial mRNA and its translation into proteins followed by pioneering work on muscle ...
Yaniv, Moshe
doaj   +1 more source

HIV mRNA Vaccines—Progress and Future Paths

Vaccines, 2021
The SARS-CoV-2 pandemic introduced the world to a new type of vaccine based on mRNA encapsulated in lipid nanoparticles (LNPs). Instead of delivering antigenic proteins directly, an mRNA-based vaccine relies on the host’s cells to manufacture protein ...
Zekun Mu, Barton F. Haynes, Derek W. Cain   +2 more
doaj   +1 more source