Results 161 to 170 of about 1,529,458 (406)
Advanced Science, EarlyView.This paper establishes a global high‐throughput fluorescence screening (GhitFluors) platform to efficiently identify ABA signaling modulators. It effectively identifies diopyridin, a regulator with strong binding affinity to PYR1, and more than 80% inhibitory activity against HAB1, which is equivalent to ABA.
Yang‐Yang Gao +13 more
wiley +1 more source
In situ structures of the segmented genome and RNA polymerase complex inside a dsRNA virus. [PDF]
, 2015 Viruses in the Reoviridae, like the triple-shelled human rotavirus and the single-shelled insect cytoplasmic polyhedrosis virus (CPV), all package a genome of segmented double-stranded RNAs (dsRNAs) inside the viral capsid and carry out endogenous ...
Chang, Winston +5 more
core
Recent Advances in mRNA Delivery Systems for Cancer Therapy
Advanced Science, EarlyView.This review systematically investigates the applications of mRNA therapy in cancer treatment, with particular emphasis on nonviral delivery systems, targeting strategies, stimulus‐responsive systems, and local delivery methods. Concluding with a meticulous evaluation, the review sheds light on the prevailing challenges while illuminating promising ...
Zheng Zhang +9 more
wiley +1 more source
MESSENGER-RNA ATTACHMENT TO ACTIVE RIBOSOMES [PDF]
, 1962 Robert W. Risebrough +2 more
openalex +1 more source
Advanced Science, EarlyView.LGR6 overexpression ameliorates cardiac hypertrophy by regulating metabolic reprogramming through USP4‐PPARα pathway. Abstract Metabolic reprogramming is a pivotal mechanism in the pathogenesis of pathological cardiac hypertrophy. Leucine‐rich repeat‐containing G protein‐coupled receptor 6 (Lgr6) has emerged as a significant player in cardiovascular ...
Mengmeng Zhao +7 more
wiley +1 more source
Chromatin measurements reveal contributions of synthesis and decay to steady‐state mRNA levels
Molecular Systems Biology, 2012 Messenger RNA levels in eukaryotes are controlled by multiple consecutive regulatory processes, which can be classified into two layers: primary transcriptional regulation at the chromosomal level and secondary, co‐ and post‐transcriptional regulation of
Sylvia C Tippmann +8 more
doaj +1 more source
Translation of the tryptophan messenger RNA of Escherichia coli. [PDF]
, 1968 Daniel E. Morse +2 more
openalex +1 more source
Semi-Markov models of mRNA-translation [PDF]
arXiv, 2011 Translation is the cellular process in which ribosomes make proteins from information encoded on messenger RNA (mRNA). We model translation with an exclusion process taking into account the experimentally determined, non-exponential, waiting time between steps of a ribosome.
arxiv
Advanced Science, EarlyView.A unique hydrogel based on extracellular matrix from fish swim bladder, which is suitable for transcatheter delivery and possesses remarkable reparative capabilities for treating heart failure, is developed. It emerges as a multi‐effect factor profoundly influencing inflammation regulation, angiogenesis, and myocardial metabolism.
Yulong Fu +9 more
wiley +1 more source
Rare Tumors, 2018 Background: Previous studies have shown that aberrant activation of the Wnt/β-catenin pathway is associated with many malignant neoplasms. This includes some soft-tissue sarcoma phenotypes, most notably synovial sarcoma, implicating potential targets for
Laurence M Briski +6 more
doaj +1 more source