Results 41 to 50 of about 1,593,615 (383)
The importance of circulating tumor products as „liquid biopsies” in colorectal cancer [PDF]
, 2018 Liquid biopsies represent an array of plasma analysis tests that are studied to evaluate and identify circulating tumor products, especially circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA).
Calborean, Veronica +6 more
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, 2021 Messenger RNA medicines are basically sets of instructions and these instructions direct cells in the body to make proteins. mRNA plays a key role in human biology and it is a molecule that carries genetic code from DNA in a cell nucleus to ribosomes the protein making machinery of cells. Messenger RNA carries the genetic information copied from DNA in
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The emerging role of RNA modifications in the regulation of mRNA stability
Experimental and Molecular Medicine, 2020 Gene activity: the significance of RNA modification Messenger RNA molecules play their key role in directing the manufacture of proteins via translating the genetic information in DNA.
Sung Ho Boo, Yoon Ki Kim
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Advances in Materials, 2019 A main challenge to broaden the biomedical application of CRISPR/Cas9 (clustered regularly interspaced short palindromic repeat (CRISPR) associated protein 9) genome editing technique is the delivery of Cas9 nuclease and single‐guide RNA (sgRNA) into the
Ji Liu +7 more
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Frontiers in Genetics, 2023 Genetic and epigenetic reprogramming caused by disease states in other tissues is always systemically reflected in peripheral blood leukocytes (PBLs).
Yinli He +10 more
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Structural signatures of thermal adaptation of bacterial ribosomal RNA, transfer RNA, and messenger RNA. [PDF]
PLoS ONE, 2017 Temperature adaptation of bacterial RNAs is a subject of both fundamental and practical interest because it will allow a better understanding of molecular mechanism of RNA folding with potential industrial application of functional thermophilic or ...
Clara Jegousse +4 more
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Messenger RNA Fluctuations and Regulatory RNAs Shape the Dynamics of Negative Feedback Loop
, 2010 Single cell experiments of simple regulatory networks can markedly differ from cell population experiments. Such differences arise from stochastic events in individual cells that are averaged out in cell populations.
Furman, Itay +4 more
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The messenger: the structure of RNA [PDF]
Biochemical Journal, 2006 In the early part of the 20th Century, the nature of nucleic acid and what its role was within the cell were a bit of a mystery. DNA itself was first isolated as far back as 1869 by the Swiss chemist Johann Friedrich Miescher. He separated nuclei from the cytoplasm of cells and then isolated an acidic substance from these nuclei that he called nuclein1.
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Processivity and coupling in messenger RNA transcription.
PLoS ONE, 2010 BackgroundThe complexity of messenger RNA processing is now being uncovered by experimental techniques that are capable of detecting individual copies of mRNA in cells, and by quantitative real-time observations that reveal the kinetics.
Stuart Aitken +5 more
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Modelling ribosome kinetics and translational control on dynamic mRNA.
PLoS Computational Biology, 2023 The control of protein synthesis and the overall levels of various proteins in the cell is critical for achieving homoeostasis. Regulation of protein levels can occur at the transcriptional level, where the total number of messenger RNAs in the overall ...
Eric C Dykeman
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