Results 41 to 50 of about 190,885 (290)
A model for codon position bias in RNA editing [PDF]
, 2005 RNA editing can be crucial for the expression of genetic information via inserting, deleting, or substituting a few nucleotides at specific positions in an RNA sequence. Within coding regions in an RNA sequence, editing usually occurs with a certain bias
Bundschuh, Ralf, Liu, Tsunglin
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The messenger: the structure of RNA [PDF]
Biochemical Journal, 2006 In the early part of the 20th Century, the nature of nucleic acid and what its role was within the cell were a bit of a mystery. DNA itself was first isolated as far back as 1869 by the Swiss chemist Johann Friedrich Miescher. He separated nuclei from the cytoplasm of cells and then isolated an acidic substance from these nuclei that he called nuclein1.
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Splicing of Messenger RNA Precursors
Cold Spring Harbor Symposia on Quantitative Biology, 1987 A general mechanism for the splicing of nuclear messenger RNA precursors in eukaryotic cells has been widely accepted. This mechanism, which generates lariat RNAs possessing a branch site, seems related to the RNA-catalyzed reactions of self-splicing introns.
Sharp, P. A. +5 more
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Rapid nuclear deadenylation of mammalian messenger RNA
iScience, 2023 Summary: Poly(A) tails protect RNAs from degradation and their deadenylation rates determine RNA stability. Although poly(A) tails are generated in the nucleus, deadenylation of tails has mostly been investigated within the cytoplasm.
Jonathan Alles +3 more
doaj
Modelling ribosome kinetics and translational control on dynamic mRNA.
PLoS Computational Biology, 2023 The control of protein synthesis and the overall levels of various proteins in the cell is critical for achieving homoeostasis. Regulation of protein levels can occur at the transcriptional level, where the total number of messenger RNAs in the overall ...
Eric C Dykeman
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Тонкие химические технологии, 2022 Objectives. To evaluate the effect of cellular genes FLT4, Nup98, and Nup205 on the reproduction of the influenza A virus in A549 human lung cancer cell line.Methods.
E. A. Pashkov +11 more
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Regulated Inositol‐Requiring Protein 1‐Dependent Decay as a Mechanism of Corin RNA and Protein Deficiency in Advanced Human Systolic Heart Failure [PDF]
, 2014 BACKGROUND: The compensatory actions of the endogenous natriuretic peptide system require adequate processing of natriuretic peptide pro‐hormones into biologically active, carboxyl‐terminal fragments.
Barton, P +5 more
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LTD4 and TGF-β1 induce the expression of metalloproteinase-1 in chronic rhinosinusitis via a cysteinyl leukotriene receptor 1-related mechanism [PDF]
, 2016 A
Bachert, Claus +4 more
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Who discovered messenger RNA? [PDF]
Current Biology, 2015 The announcement of the discovery of messenger RNA (mRNA) and the cracking of the genetic code took place within weeks of each other in a climax of scientific excitement during the summer of 1961. Although mRNA is of decisive importance to our understanding of gene function, no Nobel Prize was awarded for its discovery.
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From omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, EarlyView.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan +2 more
wiley +1 more source