Results 161 to 170 of about 3,947 (253)

Pharmacokinetics of ethinyl estradiol and mestranol

American Journal of Obstetrics and Gynecology, 1990
Pharmacokinetally, a 50 micrograms oral dose of mestranol (which itself is inactive) is bioequivalent to a 35 micrograms dose of ethinyl estradiol. Physiologically, mestranol ranges from 50% to 100% of the activity of ethinyl estradiol, depending on the endpoint chosen.
Joseph W Goldzieher
exaly   +4 more sources

Improved synthesis of mestranol and ethinyl estradiol (EE) related degradation products as authentic references

Steroids, 2008
Hongqi Li, Yanxi Song
exaly   +3 more sources

NMR Analysis of Mestranol Bulk Drug

Journal of Pharmaceutical Sciences, 1970
A double assay procedure for mestranol is described. The method is based upon measurement of the NMR spectrum of mestranol in pyridine, using diphenylacetic acid as an internal standard. The signals chosen are those from the methoxyl and ethinyl groups. Three commercial lots of the steroid were studied, and a TLC study of each lot is described.
B A Lodge
exaly   +3 more sources

Norethynodrel With Mestranol in Treatment of Rheumatoid Arthritis

JAMA, 1964
THE AVAILABILITY of a 19-nor progestational compound mixed with a small amount of estrogenic substance provided the opportunity to study the effect of the pseudopregnant state of the course of rheumatoid arthritis in a selected group of patients. Seventeen patients, 13 females and four males, participated in the blindfold study.
M, GILBERT, J, ROTSTEIN, C, CUNNINGHAM, I, ESTRIN, A, DAVIDSON, G, PINCUS   +5 more
openaire   +3 more sources

The Accumulation of Mestranol and Ethynyloestradiol Metabolites in the Organism

Xenobiotica, 1972
1. Following a single intravenous administration of [6,7–3H]ethynyloestradiol and [6,7–3H]mestranol to female rats, 55% of the labelling was excreted in the faeces within 3 weeks, whereas only small amounts of radioactivity (1.5%) were recovered from urine during the first 3 days.
H M, Bolt, H, Remmer
openaire   +3 more sources

DEMETHYLATION OF MESTRANOL TO ETHINYLOESTRADIOL IN VITRO AND IN VIVO

Acta Endocrinologica, 1972
ABSTRACT The present concept is that mestranol must be demethylated to ethinyl-oestradiol in order to have oestrogenic activity. This activation of mestranol has been studied in vivo by means of radiospirometry and in vitro incubations with rat liver microsomes.
H, Kappus, H M, Bolt, H, Remmer
openaire   +3 more sources

NMR-based metabonomic evaluation of livers from rats chronically treated with tamoxifen, mestranol, and phenobarbital

Metabolomics, 2005
Laura K Schnackenberg, Richard D Beger, Beger Richard D   +2 more
exaly   +2 more sources

A survey of 17α-ethinylestradiol and mestranol residues in Hawkesbury River, Australia, using a highly specific enzyme-linked immunosorbent assay (ELISA) demonstrates the levels of potential biological significance

Ecotoxicology and Environmental Safety, 2017
Ivan R Kennedy, VÍCTOR Wong, Nanju Alice Lee   +2 more
exaly   +2 more sources

In vitro and in vivo genotoxicity evaluation of hormonal drugs v. mestranol

Mutation Research - Genetic Toxicology Testing and Biomonitoring of Environmental Or Occupational Exposure, 1994
Varinderpal S Dhillon
exaly   +2 more sources

Affinity of ethynyl-estradiol and mestranol for the uterine estrogen receptor and for the microsomal mixed function oxidase of the liver

The Journal of Steroid Biochemistry, 1973
H Kappus, H M Bolt, H Remmer
exaly   +2 more sources