Results 141 to 150 of about 412,114 (244)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Unexpected brain metastases from neuroendocrine prostate cancer detected by [¹⁸F]fluorocholine PET/CT: a case report. [PDF]

Front Med (Lausanne)
Benameur Y, Hommadi M, Sahel OA, Oueriagli SN, Zahfir I, Aboussabr M, Bakkali JE, Doudouh A.   +7 more
europepmc   +1 more source

Por Vezes o Carcinoma diferenciado da tiróide é agressivo [PDF]

, 2013
Vânia Isabel Gomes Alves Fernandes
core  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Molecular landscape of prostate cancers with clival metastases. [PDF]

Oncologist
Likasitwatanakul P, Blinka SM, Zarka JG, Gebrael G, Weg E, Longoria O, Moore JA, Sharp A, de Bono J, Sternberg CN, Agarwal N, Swami U, Orme JJ, Schweizer MT, Sloan L, Hwang JH, Antonarakis ES.   +16 more
europepmc   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Poor Outcome of Metastatic Cutaneous Squamous Cell Carcinoma: A Swedish Retrospective Study. [PDF]

Acta Derm Venereol
Palmqvist CL, Von Beckerath M.
europepmc   +1 more source

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source

A Case of Microwave Ablation Activating Immune Response in Pulmonary Metastases from Hepatocellular Carcinoma. [PDF]

J Hepatocell Carcinoma
Wan J, Jin C, Li C, Zhang W, Zhou Y, Yu C, Fan Z, Qu X.   +7 more
europepmc   +1 more source

Tumores neuro-endócrinos do Pâncreas [PDF]

, 2014
Inês Barbosa Santos de Aguiar Pereira
core