Results 81 to 90 of about 407,464 (291)

Age as an independent prognostic factor in breast cancer [PDF]

, 2008
OBJETIVO: comparar as características epidemiológicas e clínicas e a evolução pós-tratamento de mulheres com câncer de mama diagnosticadas antes ou após os 40 anos de idade.
ABRÃO, Renato Antonio, ANDRADE, Jurandyr Moreira de, CARRARA, Hélio Humberto Angotti, CLAGNAN, Willian Simões, MARANA, Heitor Ricardo Cosiski, REIS, Francisco José Candido dos, TIEZZI, Daniel Guimarães   +6 more
core   +2 more sources

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Intraoperative ultrasonography for presumed brain metastases: a case series study

Arquivos de Neuro-Psiquiatria, 2012
Brain metastases (BM) are one of the most common intracranial tumors and surgical treatment can improve both the functional outcomes and patient survival, particularly when systemic disease is controlled.
Helder Picarelli, Marcelo de Lima Oliveira, Edson Bor-Seng-Shu, Eduardo Santamaria Carvalhal Ribas, Alexandre Maria Santos, Manoel Jacobsen Teixeira   +5 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Efeito Anti-Tumoral dos Bisfosfonatos: uma Nova Perspectiva Terapêutica

Revista Brasileira de Cancerologia, 2004
Os bisfosfonatos (BFs) são potentes inibidores da reabsorção óssea mediada por osteoclastos. Essas drogas são efetivas na redução do cálcio sérico em pacientes com hipercalcemia maligna, assim como também no tratamento da dor óssea, osteoporose e ...
Déborah V. Vasconcellos, Maria Eugenia L. Duarte, Raquel C. Maia   +2 more
doaj   +1 more source

Malignant melanoma with liver and spleen metastases: case report [PDF]

, 2000
CONTEXT: The diagnosis of primary melanoma is easily confirmed after histological analysis of the lesion, whereas it is rarely diagnosed when the patient even has distant metastases.
Lanzoni, Valeria Pereira, Ornellas, Laura Cotta, Toledo, Carlos Fischer de   +2 more
core   +4 more sources

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Simultaneous left colectomy and standard hepatectomy reformed by laparoscopy [PDF]

, 2011
As abordagens laparoscópicas têm sido cada vez mais utilizadas em pacientes com câncer colorretal ou hepático. Colectomia e hepatectomia simultâneas são consideradas técnicas seguras e apresentam resultados oncológicos semelhantes independente da ...
HERMAN, Paulo, LUPINACCI, Renato Arioni, LUPINACCI, Renato Micelli, MACHADO, Marcel Autran   +3 more
core   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source