Results 161 to 170 of about 946,904 (210)
Some of the next articles are maybe not open access.
The conversion of met-enkephalin-Arg6, Phe7 to met-enkephalin in rabbit ear artery
Life Sciences, 1983We studied the opioid agonist activities of met-enkephalin-Arg6, Phe7 heptapeptide (ME-A,P) and its D-Ala2-analogue in several isolated organs including rabbit ear artery (ART), guinea-pig ileum (GPI) mouse-, rat and rabbit vas deferens preparation. Both heptapeptides followed the in vitro activity pattern of met-enkephalin (ME).
A Z, Rónai +3 more
openaire +2 more sources
Interaction of met-enkephalin and corticosteroids in immunomodulation
International Journal of Immunopharmacology, 1992The effect of Met-enkephalin (MENK) on several immune functions, corticosterone (CS) and adrenocorticotropin (ACTH) levels in the plasma was studied in adrenalectomized (ADX) and sham-adrenalectomized (SADX) mice. Multiple Met-enkephalin injections (10 mg/kg per day in two injections 12 h apart, for 4 days) increased the plaque-forming cell response to
Gabrilovac, Jelka +3 more
openaire +3 more sources
Life Sciences, 1983
Studies on the nucleotide sequence of cloned DNA complementary to mRNA for preproenkephalin A from adrenal medulla and human pheochromocytoma have revealed that this precursor contains 4 copies of methionine-enkephalin(Met-Enk) and one copy each of leu-enkephalin (Leu-Enk), methionine-enkephalin-Arg6-Gly7-Leu8(Met-Enk-Arg6-Gly7-Leu8) and methionine ...
M, Sakamoto +6 more
openaire +2 more sources
Studies on the nucleotide sequence of cloned DNA complementary to mRNA for preproenkephalin A from adrenal medulla and human pheochromocytoma have revealed that this precursor contains 4 copies of methionine-enkephalin(Met-Enk) and one copy each of leu-enkephalin (Leu-Enk), methionine-enkephalin-Arg6-Gly7-Leu8(Met-Enk-Arg6-Gly7-Leu8) and methionine ...
M, Sakamoto +6 more
openaire +2 more sources
Met-enkephalin circulates in human plasma
Nature, 1980The physiological roles of Met-enkephalin and Leu-enkephalin are still unknown. They may act as neurotransmitters in the central and peripheral nervous systems. Met-enkephalin has been detected in several species in a variety of tissues including brain, spinal cord and gut using bioassays, opiate receptor assays and radioimmunoassays (RIA). It has also
V, Clement-Jones +3 more
openaire +2 more sources
Met-enkephalin receptors in human gliomas
NeuroReport, 1994Endogenous opioid systems (opioid peptides and receptors) are involved in many functions including the regulation of cell growth. We investigated the presence of Met-enkephalin binding sites in gliomas by displacement assays. Results demonstrated that few gliomas exhibit Met-enkephalin binding sites and that the percentage of tumours which express ...
L, Molin +3 more
openaire +2 more sources
Interaction of Met‐Enkephalin with Human Granulocytes
Annals of the New York Academy of Sciences, 1987Met-enkephalin has been found to have an effect on cell shape and motility of human polymorphonuclear leukocytes (PMNs). Specific binding of tritium-labeled Met-enkephalin to the cells could not be demonstrated. There was a rapid proteolytic degradation of the peptide in the medium, followed by uptake of the labeled tyrosine.
E G, Fischer, N E, Falke
openaire +2 more sources
Biochemical and Biophysical Research Communications, 1981
Abstract Enzymes degrading Met-enkephalin-Arg 6 -Phe 7 , an endogenous brain peptide with enhanced opiate activity in vivo, were isolated from membrane preparations of rabbit kidney and brain, and their specificity compared. A preparation from kidney or brain containing the angiotensin converting enzyme (EC 3.4.15.1) released with time Arg-Phe, Met ...
M, Benuck, M J, Berg, N, Marks
openaire +2 more sources
Abstract Enzymes degrading Met-enkephalin-Arg 6 -Phe 7 , an endogenous brain peptide with enhanced opiate activity in vivo, were isolated from membrane preparations of rabbit kidney and brain, and their specificity compared. A preparation from kidney or brain containing the angiotensin converting enzyme (EC 3.4.15.1) released with time Arg-Phe, Met ...
M, Benuck, M J, Berg, N, Marks
openaire +2 more sources
Met-Enkephalin in Oxidative Stress
2006Hugo Besedovsky demonstrated immune-brain communications more than 35 years ago. His recent findings concern the ability of IL-1 (centrally mediated immune challenge) to induce hypoglycaemia (response of immune tissue on periphery). So we no longer question that injection of immune modulators can affect the brain or that the immune system can interfere
Haberstock-Debić, Helena +4 more
openaire +3 more sources
Cell and Tissue Research, 1985
Region-specific antisera to three enkephalins: met-enkephalin, met-enkephalin-Arg6-Phe7 and met-enkephalin-Arg6-Gly7-Leu8, together with four region specific antisera to progastrin: C-terminal G17 specific, N-terminal G34 specific, cryptic peptides A- and B-specific, were used in immunohistochemical studies of hog antral mucosa. A sub-population (6-10%)
openaire +2 more sources
Region-specific antisera to three enkephalins: met-enkephalin, met-enkephalin-Arg6-Phe7 and met-enkephalin-Arg6-Gly7-Leu8, together with four region specific antisera to progastrin: C-terminal G17 specific, N-terminal G34 specific, cryptic peptides A- and B-specific, were used in immunohistochemical studies of hog antral mucosa. A sub-population (6-10%)
openaire +2 more sources
Enzymatic synthesis of Leu- and Met-enkephalin
Biochemical and Biophysical Research Communications, 1979Abstract The protease-catalyzed synthesis of Leu- and Met-enkephalin is reported. Each peptide bond of the endogeneous opiate-pentapeptides was formed either by papain or α-chymotrypsin catalysis. N-acyl amino acids and peptides or their ester derivatives served as substrates whereas amino acid and peptide phenylhydrazides were used as nucleophiles ...
openaire +2 more sources