Results 61 to 70 of about 66,169,145 (313)

Immunotherapy with Sipuleucel-T (APC8015) in patients with metastatic castration-refractory prostate cancer (mCRPC): a systematic review and meta-analysis

International Brazilian Journal of Urology, 2012
Objective To perform a systematic review and meta-analysis of all randomized controlled trials comparing the efficacy of Sipuleucel-T versus placebo for asymptomatic or minimally symptomatic metastatic castration-refractory prostate cancer (mCRPC).
Tobias Engel Ayer Botrel, Otávio Clark, Antônio Carlos Lima Pompeo, Francisco Flávio Horta Bretas, Marcus Vinicius Sadi, Ubirajara Ferreira, Rodolfo Borges dos Reis   +6 more
doaj   +1 more source

Topical NSAIDs for chronic musculoskeletal pain: systematic review and meta-analysis [PDF]

BMC Musculoskeletal Disorders, 2004
Abstract A previous systematic review reported that topical NSAIDs were effective in relieving pain in chronic conditions like osteoarthritis and tendinitis. More trials, a better understanding of trial quality and bias, and a reclassification of certain drugs necessitate a new review. Methods
Derry Sheena, Edwards Jayne E, Moore R Andrew, Mason Lorna, McQuay Henry J   +4 more
openaire   +3 more sources

An improved method for bivariate meta-analysis when within-study correlations are unknown. [PDF]

, 2018
Multivariate meta-analysis, which jointly analyzes multiple and possibly correlated outcomes in a single analysis, is becoming increasingly popular in recent years. An attractive feature of the multivariate meta-analysis is its ability to account for the

core   +1 more source

Exploring the influence of lactoferrin on wound healing and related signaling pathways: a systematic review

FEBS Open Bio, EarlyView.
Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo, Kátia Cristiane Hall, Matheus dos Santos Fernandez, Geovanna Peter Corrêa, Rafael Guerra Lund   +4 more
wiley   +1 more source

Revisão sistemática da acurácia dos testes diagnósticos: uma revisão narrativa

Revista do Colégio Brasileiro de Cirurgiões
Este artigo tem o objetivo de realizar uma revisão narrativa sobre revisão sistemática da acurácia dos testes diagnósticos. Foi realizada busca na Cochrane Methodology Reviews (Cochrane Reviews of Diagnostic Test Accuracy), Medline e LILACS, bem como ...
Glória Maria de Oliveira, Fábio Trinca Camargo, Eduardo Costa Gonçalves, Carlos Vinicius Nascimento Duarte, Carlos Alberto Guimarães   +4 more
doaj   +1 more source

Reslizumab versus placebo for poorly controlled, severe eosinophilic asthma: Meta-analysis [PDF]

Vojnosanitetski Pregled, 2018
Background/Aim. Reslizumab is humanized monoclonal antibody produced by recombinant DNA technology which binds to circulating interleukin-5 (IL-5) and down-regulates the IL-5 signaling pathway. Reslizumab is indicated for the add-on maintenance treatment
Milosavljević Miloš N., Janković Slobodan M., Pejčić Ana V., Milovanović Jasmina R., Opančina Valentina D., Kostić Marina J.   +5 more
doaj   +1 more source

Topical hemostatic agents in the management of upper gastrointestinal bleeding: a meta-analysis

Endoscopy International Open, 2022
Abstract Background and study aims Novel topical hemostatic agents have shown promising results in treating patients with non-variceal upper gastrointestinal bleeding (NVUGIB). However, data are limited even in published meta-analyses as to their role, especially compared to conventional endoscopic approaches.
Ali A. Alali, Sarvee Moosavi, Myriam Martel, Majid Almadi, Alan N. Barkun   +4 more
openaire   +3 more sources

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

FEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta, Sebastian GB Furness, Tahereh Gharbi, Ric De Paoli‐Iseppi, Shweta S. Joshi, Michael Clark, David L. Hare, Peter Wookey   +7 more
wiley   +1 more source

An alternative approach to deal with the absence of clinical trials: a proportional meta-analysis of case series studies [PDF]

Acta Cirúrgica Brasileira, 2013
PURPOSE: Systematic reviews are criticized for frequently offering inconsistent evidences and absence of straightforward recommendations. Their value seems to be depreciated when the conclusions are uncertain.
Regina El Dib, Paulo Nascimento Junior, Anil Kapoor   +2 more
doaj   +2 more sources

Topical Agents in Biofilm Disaggregation: A Systematic Review and Meta-Analysis

Journal of Clinical Medicine
Background: to evaluate the effectiveness of different topical agents in biofilm disaggregation during non-surgical periodontal therapy. Methods: the search strategy was conducted according to the PRISMA 2020 on Pubmed, Cochrane Library, Scopus, and Web of Science, and it was registered in PROSPERO, ID: CRD42023474232. It included studies comparing non-
Pardo, Alessia, Fiorini, Vera, Zangani, Alessandro, Faccioni, Paolo, Signoriello, Annarita, Albanese, Massimo, Lombardo, Giorgio   +6 more
openaire   +3 more sources