Results 71 to 80 of about 480,085 (318)

An alternative approach to deal with the absence of clinical trials: a proportional meta-analysis of case series studies [PDF]

Acta Cirúrgica Brasileira, 2013
PURPOSE: Systematic reviews are criticized for frequently offering inconsistent evidences and absence of straightforward recommendations. Their value seems to be depreciated when the conclusions are uncertain.
Regina El Dib, Paulo Nascimento Junior, Anil Kapoor   +2 more
doaj   +2 more sources

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Revisão sistemática da acurácia dos testes diagnósticos: uma revisão narrativa

Revista do Colégio Brasileiro de Cirurgiões
Este artigo tem o objetivo de realizar uma revisão narrativa sobre revisão sistemática da acurácia dos testes diagnósticos. Foi realizada busca na Cochrane Methodology Reviews (Cochrane Reviews of Diagnostic Test Accuracy), Medline e LILACS, bem como ...
Glória Maria de Oliveira, Fábio Trinca Camargo, Eduardo Costa Gonçalves, Carlos Vinicius Nascimento Duarte, Carlos Alberto Guimarães   +4 more
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Using conversation topics for predicting therapy outcomes in schizophrenia. [PDF]

, 2013
This article is available from http://www.la-press.com. © the author(s), publisher and licensee Libertas Academica Ltd. This is an open access article published under the Creative Commons CC-BY-NC 3.0 license.Previous research shows that aspects of ...
McCabe, R., Purver, M, McCabe, R, Purver, Matthew, Rose Mccabe, McCabe, Rose, Howes, C., Purver, M., Howes, C, Howes, Christine, Matthew Purver, Christine Howes   +11 more
core   +1 more source

Topical Agents in Biofilm Disaggregation: A Systematic Review and Meta-Analysis

Journal of Clinical Medicine
Background: to evaluate the effectiveness of different topical agents in biofilm disaggregation during non-surgical periodontal therapy. Methods: the search strategy was conducted according to the PRISMA 2020 on Pubmed, Cochrane Library, Scopus, and Web of Science, and it was registered in PROSPERO, ID: CRD42023474232. It included studies comparing non-
Pardo, Alessia, Fiorini, Vera, Zangani, Alessandro, Faccioni, Paolo, Signoriello, Annarita, Albanese, Massimo, Lombardo, Giorgio   +6 more
openaire   +3 more sources

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

OnabotulinumtoxinA for neurogenic detrusor overactivity and dose differences: a systematic review

International Brazilian Journal of Urology, 2015
Purpose To evaluate the efficacy and safety of onabotulinumtoxinA for patients with neurogenic detrusor overactivity (NDO). Materials and Methods We searched the Cochrane Library, PUBMED, EMBASE, Chinese Bio-medicine database, China Journal Full-text ...
Rui Zhang, Yongteng Xu, Shengping Yang, Hui Liang, Yunxin Zhang, Yali Liu   +5 more
doaj   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Topical NSAIDs for chronic musculoskeletal pain: systematic review and meta-analysis [PDF]

BMC Musculoskeletal Disorders, 2004
AbstractA previous systematic review reported that topical NSAIDs were effective in relieving pain in chronic conditions like osteoarthritis and tendinitis. More trials, a better understanding of trial quality and bias, and a reclassification of certain drugs necessitate a new review. Methods Studies were
Derry Sheena, Edwards Jayne E, Moore R Andrew, Mason Lorna, McQuay Henry J   +4 more
openaire   +3 more sources