Results 101 to 110 of about 5,522,237 (352)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Benefits of Bariatric Surgery and Perioperative Surgical Safety [PDF]

open access: yesEuropean Medical Journal Diabetes, 2015
Obesity is a worldwide problem with numerous associated health problems. The number of patients eligible for surgery outnumber surgical capacity and so patients need to be prioritised based on their obesity- related health burden and comorbidities ...
Ji Chung Tham, Carel W. le Roux
doaj  

Clinical Value of Machine Learning in the Automated Detection of Focal Cortical Dysplasia Using Quantitative Multimodal Surface-Based Features

open access: yesFrontiers in Neuroscience, 2019
Objective: To automatically detect focal cortical dysplasia (FCD) lesion by combining quantitative multimodal surface-based features with machine learning and to assess its clinical value.Methods: Neuroimaging data and clinical information for 74 ...
Jia-Jie Mo   +12 more
doaj   +1 more source

Flux networks in metabolic graphs [PDF]

open access: yes, 2009
A metabolic model can be represented as bipartite graph comprising linked reaction and metabolite nodes. Here it is shown how a network of conserved fluxes can be assigned to the edges of such a graph by combining the reaction fluxes with a conserved ...
Dantzig G B   +9 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Vibration Emissions Reduce Boar Sperm Quality via Disrupting Its Metabolism

open access: yesBiology
Artificial insemination (AI) with liquid-preserved semen has recently become common in pig breeding. The semen doses are produced in a centralized manner at the boar stud and then subsequently distributed and transported to sow farms.
Shanpeng Wang   +6 more
doaj   +1 more source

AZILSARTAN AS A POTENT ANTIHYPERTENSIVE DRUG WITH POSSIBLE PLEIOTROPIC CARDIOMETABOLIC EFFECTS: A REVIEW STUDY.

open access: yesFrontiers in Pharmacology, 2016
Background: Hypertension related cardiovascular (CV) complications could be amplified by the presence of metabolic co-morbidities. Azilsartan medoxomil (AZL-M) is the eighth approved member of angiotensin II receptor blockers (ARBs), a drug class of high
Georgiopoulos Georgios   +9 more
doaj   +1 more source

Simplified Diet for nutrition management of phenylketonuria: A survey of U.S. metabolic dietitians

open access: yesJIMD Reports, 2020
Background Phenylketonuria (PKU) is an inherited metabolic disorder affecting the conversion of phenylalanine (Phe) to tyrosine. Medical nutrition therapy, consisting of a Phe‐restricted diet with medical formula, is the primary treatment for PKU.
Joyanna Hansen   +5 more
doaj   +1 more source

Metabolic disorders in kidney stone disease in children

open access: yesJournal of Education, Health and Sport, 2020
Urolithiasis is not a rare disorder in children. Its etiology, incidence and localization vary by geographic region. It is an increasing problem, especially in developing countries.
Monika Kusz   +4 more
doaj   +1 more source

Phosphofructokinase 1 Glycosylation Regulates Cell Growth and Metabolism [PDF]

open access: yes, 2012
Cancer cells must satisfy the metabolic demands of rapid cell growth within a continually changing microenvironment. We demonstrated that the dynamic posttranslational modification of proteins by O-linked β-N-acetylglucosamine (O-GlcNAcylation) is a key ...
Clark, Peter M.   +8 more
core   +2 more sources

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