Results 81 to 90 of about 5,522,237 (352)

Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): A State-of-the-Art Review

Journal of Obesity & Metabolic Syndrome, 2023
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the latest term for steatotic liver disease associated with metabolic syndrome.
W. Chan, Kee-Huat Chuah, R. Rajaram, Lee-Ling Lim, J. Ratnasingam, S. Vethakkan   +5 more
semanticscholar   +1 more source

Metabolic regulation of regulatory T cell development and function [PDF]

, 2014
It is now well established that the effector T cell (Teff) response is regulated by a series of metabolic switches. Quiescent T cells predominantly require ATP-generating processes, whereas proliferating Teff require high metabolic flux through growth ...
Alves, Barbi, Battaglia, Bental, Borsellino, Carr, Cipolletta, Cobbold, Coloff, Cunningham, Curti, Cybulski, Dang, Deiuliis, Delgoffe, Delgoffe, Feuerer, Fisson, Fox, Frauwirth, GabryÅ¡ová, Greiner, Guertin, Guertin, Gulen, Hardie, Hardie, Howie, Hörig, Jacobs, Jones, Jordan, Kane, Lee, Lord, Makki, Matarese, Matteoli, Mellor, Metz, Michalek, Munder, Munder, Oh, Olefsky, Ouchi, Peter, Powell, Powell, Powell, Powell, Procaccini, Procaccini, Sakaguchi, Sarbassov, Shevach, Shi, Sitkovsky, Smith, Thornton, Vanasek, Vander Heiden, Vukmanovic-Stejic, Waickman, Wieman, Winer, Yang, Zeng, Zheng   +68 more
core   +2 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

The global burden of metabolic disease: Data from 2000 to 2019.

Cell Metabolism, 2023
Global estimates of prevalence, deaths, and disability-adjusted life years (DALYs) from the Global Burden of Diseases, Injuries, and Risk Factors Study 2019 were examined for metabolic diseases (type 2 diabetes mellitus [T2DM], hypertension, and non ...
N. Chew, C. Ng, D. Tan, G. Kong, Chaoxing Lin, Y. Chin, W. Lim, Daniel Q. Huang, Jingxuan Quek, Clarissa Fu, J. Xiao, N. Syn, R. Foo, C. Khoo, Jiongwei Wang, G. Dimitriadis, D. Young, M. Siddiqui, Carolyn S P Lam, Yibin Wang, G. Figtree, M. Chan, D. Cummings, M. Noureddin, V. W. Wong, R. Ma, C. Mantzoros, Arunda Sanyal, M. Muthiah   +28 more
semanticscholar   +1 more source

Animal models of NASH: getting both pathology and metabolic context right [PDF]

, 2015
Non-alcoholic fatty liver disease (NAFLD) is the most common cause of referral to liver clinics, and its progressive form, non-alcoholic steatohepatitis (NASH), can lead to cirrhosis and end-stage liver disease.
Larter, Claire Z., Yeh, Matthew M.
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Metabolite Profiling and Transcriptome Analyses Provide Insight Into Phenolic and Flavonoid Biosynthesis in the Nutshell of Macadamia Ternifolia

Frontiers in Genetics, 2022
Macadamia ternifolia is a dynamic oil-producing nut crop in the world. However, the nutshell is frequently considered as a low-quality material. Further, its metabolic profile is still uncharacterized.
Rui Shi, Liang Tao, Xinghao Tu, Chunsheng Zhang, Zhi Xiong, Abraham Rami Horowitz, Jiftah Ben Asher, Jun He, Faguang Hu   +8 more
doaj   +1 more source

Metabolic network modularity arising from simple growth processes

, 2012
Metabolic networks consist of linked functional components, or modules. The mechanism underlying metabolic network modularity is of great interest not only to researchers of basic science but also to those in fields of engineering.
Takemoto, Kazuhiro
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source