Results 111 to 120 of about 360,017 (261)

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Global burden of thyroid cancer attributable to metabolic risk factors in women of reproductive age (20–49 years): a GBD 2021 cross-national analysis with projections to 2050

BMC Women's Health
Background Thyroid cancer incidence has risen steadily worldwide, making it one of the most common endocrine malignancies. Women of reproductive age experience rates roughly three times higher than men, a disparity increasingly attributed not only to ...
Houzhi Li, Yuan Liu, Zifeng Peter Hu, Eddie Lin, Chenjun Teng   +4 more
doaj   +1 more source

Exercise reduces metabolic burden while altering the immune system in aged mice. [PDF]

Aging (Albany NY), 2021
Yoon KJ, Ahn A, Park SH, Kwak SH, Kwak SE, Lee W, Yang YR, Kim M, Shin HM, Kim HR, Moon HY.   +10 more
europepmc   +1 more source

Biomarkers for High Metabolic Burden in Neurologic Disease

Journal of Neuroscience and Neurological Disorders
Neurologic diseases are recognized to have multifactorial origins well beyond mere genetic predisposition. Nutritional burdens have been identified to contribute to neurodegeneration. Healthy diets are becoming increasingly appreciated to potentially play key roles in both the developing and developed world of reducing incidences of neurologic diseases,
openaire   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Disruption of the Snf1 Gene Enhances Cell Growth and Reduces the Metabolic Burden in Cellulase-Expressing and Lipid-Accumulating Yarrowia lipolytica. [PDF]

Front Microbiol, 2021
Wei H, Wang W, Knoshaug EP, Chen X, Van Wychen S, Bomble YJ, Himmel ME, Zhang M.   +7 more
europepmc   +1 more source

The burden of cancer in metabolic dysfunction-associated steatotic liver disease

Romanian Journal of Morphology and Embryology
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent chronic liver disease worldwide and has become a major public health problem. MASLD frequently progresses to cirrhosis and hepatocellular carcinoma, but recent studies also show a frequent association with extrahepatic cancers.
Pîrvu, Bianca Florentina, Clenciu, Diana, Beldie, Luiza Andreea, Dica, Cristina Camelia, Burticală, Marilena Alexandra, Ţenea-Cojan, Tiberiu Ştefăniţă, Mitrea, Adina, Amzolini, Anca Maria, Efrem, Ion Cristian, Mogoş, Gabriel Florin Răzvan, Vladu, Ionela Mihaela   +10 more
openaire   +2 more sources

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Obesity and metabolic syndrome in patients with heart failure with preserved ejection fraction: a cross-sectional analysis of the Veradigm Cardiology Registry

BMC Endocrine Disorders
Background The proportion of heart failure patients with preserved ejection fraction has been rising over the past decades and has coincided with increases in the prevalence of obesity and metabolic syndrome. The relationship between these interconnected
Jay P Bae, Lee Kallenbach, David R Nelson, Kevin Lavelle, Jessamine P Winer-Jones, Machaon Bonafede, Masahiro Murakami   +6 more
doaj   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source