Results 101 to 110 of about 360,017 (261)
Synaptic vesicle pools are a major hidden resting metabolic burden of nerve terminals. [PDF]
Sci Adv, 2021 Pulido C, Ryan TA.
europepmc +1 more source
Metabolic EngineeringThe production of recombinant proteins in a host using synthetic constructs such as plasmids comes at the cost of detrimental effects such as reduced growth, energetic inefficiencies, and other stress responses, collectively known as metabolic burden.
Omid Oftadeh, Vassily Hatzimanikatis
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Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Predicting high recombinant protein producer strains of Pichia pastoris MutS using the oxygen transfer rate as an indicator of metabolic burden. [PDF]
Sci Rep, 2022 Wollborn D +5 more
europepmc +1 more source
Relieving metabolic burden to improve robustness and bioproduction by industrial microorganisms
Biotechnology AdvancesMetabolic burden is defined by the influence of genetic manipulation and environmental perturbations on the distribution of cellular resources. The rewiring of microbial metabolism for bio-based chemical production often leads to a metabolic burden, followed by adverse physiological effects, such as impaired cell growth and low product yields ...
Jiwei, Mao +7 more
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Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Smoking contribution to the global burden of metabolic disorder: A cluster analysis
Medicina ClínicaSmoking is associated with various health risks, including cancer, cardiovascular disease, and chronic obstructive pulmonary disease. In this retrospective cohort study, we aimed to determine whether smoking is harmful to the whole metabolic system.We collected data from 340 randomly selected participants who were divided into three groups: smokers (n ...
Hua, Zhong +3 more
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Molecular Oncology, EarlyView.The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant +7 more
wiley +1 more source
Frontiers in NutritionBackgroundColorectal cancer (CRC) represents a significant public health challenge in China. With the rising prevalence of metabolic disorders such as obesity and diabetes, it is essential to understand the long-term burden of CRC attributable to ...
Zhouwei Zhan +7 more
doaj +1 more source
The dual burden of obesity: decoding metabolism and female reproductive endocrinology
Frontiers in PhysiologyThe global prevalence of obesity continues to rise, posing a threat to health, especially among women, where obesity can lead to reproductive endocrine disorders. Adipose tissue interacts with endocrine hormones, including insulin, leptin, and sex hormones, resulting in functional abnormalities of the female hypothalamic-pituitary-ovarian axis through ...
Chen, Yan +3 more
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