Results 81 to 90 of about 360,017 (261)
Cell & BioscienceMetabolic disorders are currently threatening public health worldwide. Discovering new targets and developing promising drugs will reduce the global metabolic-related disease burden.
Jinming Zhang +8 more
doaj +1 more source
Frontiers in Cardiovascular MedicineObjectivesAtrial fibrillation/flutter (AF/AFL) is increasingly correlated with metabolic risk factors. This study analyzed mortality, disability-adjusted life years (DALYs), annual percentage changes (APCs), and estimated annual percentage changes (EAPCs)
Lu Wang +6 more
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
BMC Cardiovascular DisordersBackground Recurrence after first radiofrequency catheter ablation remains common in patients with non-valvular persistent atrial fibrillation. Cardiovascular-kidney-metabolic burden may contribute to atrial remodeling and adverse ablation outcomes, but ...
Peiyang Zheng +8 more
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Global burden of chronic kidney disease due to diabetes mellitus, 1990-2021, and projections to 2050
Frontiers in EndocrinologyIntroductionChronic kidney disease (CKD) is a serious complication of diabetes, and the global burden of the disease is gradually increasing.MethodsThis study systematically analyzed the trends and future projections of the worldwide burden of chronic ...
Xiao Ma +4 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Uncovering the Gut-Liver Axis Biomarkers for Predicting Metabolic Burden in Mice. [PDF]
Nutrients, 2023 Yang G, Liu R, Rezaei S, Liu X, Wan YY.
europepmc +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Frontiers in Human NeuroscienceIntroductionNeurological post-acute sequelae of COVID-19 (neuroPASC) are associated with persistent cognitive dysfunction and quality-of-life decline.
Ana I. Silva +41 more
doaj +1 more source