Results 61 to 70 of about 360,017 (261)

Association of metabolic risk factors with the severity of hepatic fibrosis and steatosis in metabolic dysfunction-associated fatty liver disease patients

Egyptian Liver Journal
Background Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD) encompasses diverse hepatic and metabolic dysfunctions. Aim To assess the relationship between cumulative metabolic burden and the severity of hepatic fibrosis and steatosis in MAFLD
Maha Elsabaawy, Warda Othman, Sameh Afify, Tamer Samir, Madiha Naguib   +4 more
doaj   +1 more source

Analysis of the burden of diabetes attributed to metabolic factors from 1990 to 2019

Shanghai yufang yixue
ObjectiveTo analyze the long-term trends of the disease burden of diabetes attributed to metabolic factors in China from 1990 to 2019, and provide scientific recommendations for diabetes prevention and control in China.MethodsDescriptive analysis was ...
TANG Zhen, XIE Yujin, GUO Xinxiang, LIU Huijuan, GUAN Rui, ZHU Feng, LI Haijing, XIAO Zhongnan, ZHONG Yu   +8 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Global burden of lung cancer attributable to metabolic and dietary risk factors: an overview of 3 decades and forecasted trends to 2036

Frontiers in Nutrition
BackgroundLung cancer (LC) is the leading cause of cancer-related burden worldwide. Unhealthy dietary patterns and related metabolic diseases, such as diabetes mellitus (DM), represent critical global public health challenges.
Yuying Xiang, Yun Chen, Lingyan Lan, Shuling Chen, Qijin Shu   +4 more
doaj   +1 more source

The clinical and economic burdens of metabolic dysfunction-associated steatohepatitis

Journal of Medical Economics
This study aimed to assess and compare the health care resource utilization (HCRU) and medical cost of metabolic dysfunction-associated steatohepatitis (MASH) by disease severity based on Fibrosis-4 Index (FIB-4) score among US adults in a real-world setting.
Michael, Charlton, Ivy, Tonnu-Mihara, Chia-Chen, Teng, Ziqi, Zhou, Feven, Asefaha, Rakesh, Luthra, Anthony, Hoovler, Chioma, Uzoigwe   +7 more
openaire   +2 more sources

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Metabolic Burden of Erythropoietin Stimulated Erythropoiesis in Mice

Blood, 2016
Erythropoietin (EPO) promotes erythroid differentiation and increases glucose uptake in erythroid progenitor cells in culture. The metabolic burden associated with EPO treatment in adult mice is suggested by a decrease in body weight concomitant with increased hematocrit.
Constance Tom Noguchi, Heather Marie Rogers   +1 more
openaire   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source