Results 21 to 30 of about 360,017 (261)

Sterols for Oxygen: The Metabolic Burden of Microbial SREBP [PDF]

Molecular Cell, 2011
In this issue of Molecular Cell, Lee et al. (2011) report a novel mechanism for oxygen-sensing in S. pombe, whereby the 2-OG-Fe(II) dioxygenase Ofd protein regulates both the DNA-binding activity and the degradation of the hypoxia regulated transcription factor, Sre1p.
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The metabolic burden of diabetes and dyslipidaemia in chronic kidney disease [PDF]

Nephrology Dialysis Transplantation, 2002
Hyperglycaemia induces mitochondrial superoxide production, increases oxidative stress, and leads to activation of the acute-phase response. Hyperglycaemia, impaired renal function, and uraemia cause inflammatory and oxidative processes. Advanced oxidation protein products and advanced glycation end products are formed, leading to subsequent cytokine ...
Vera, Krane, Christoph, Wanner
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Burdens of non-communicable disease attributable to metabolic risk factors in Australia, 1990–2019: joinpoint regression analysis of the Global Burden of Disease Study

BMJ Open, 2023
Background Long-term and comparative assessments of trends in non-communicable disease (NCD) burden attributable to metabolic risk are sparse. This study aimed to assess burdens and trends of NCD attributable to metabolic risk factors in Australia, 1990 ...
Kelemu Tilahun Kibret, Kathryn Backholer, Anna Peeters, Melanie Nichols, Fisaha Tesfay   +4 more
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Recombinant protein production associated growth inhibition results mainly from transcription and not from translation

Microbial Cell Factories, 2020
Background Recombinant protein production can be stressful to the host organism. The extent of stress is determined by the specific properties of the recombinant transcript and protein, by the rates of transcription and translation, and by the ...
Zhaopeng Li, Ursula Rinas
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The Burden of Antipsychotic-Induced Weight Gain and Metabolic Syndrome in Children [PDF]

Frontiers in Psychiatry, 2021
Antipsychotic medications are critical to child and adolescent psychiatry, from the stabilization of psychotic disorders like schizophrenia, bipolar disorder, and psychotic depression to behavioral treatment of autism spectrum disorder, tic disorders, and pediatric aggression. While effective, these medications carry serious risk of adverse events—most
Mark R. Libowitz, Erika L. Nurmi
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Emerging patterns and trends in global cancer burden attributable to metabolic factors, based on the Global Burden of Disease Study 2019

Frontiers in Oncology, 2023
BackgroundThe exponential growth of the cancer burden attributable to metabolic factors deserves global attention. We investigated the trends of cancer mortality attributable to metabolic factors in 204 countries and regions between 1990 and 2019 ...
Yan Zhang, Yuwei Ding, Yuwei Ding, Ning Zhu, Ning Zhu, Mi Mi, Mi Mi, Yier Lu, Yier Lu, Jia Zheng, Shanshan Weng, Ying Yuan, Ying Yuan, Ying Yuan   +13 more
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Inflammatory burden and amino acid metabolism in cancer cachexia [PDF]

Current Opinion in Clinical Nutrition & Metabolic Care, 2009
Cancer cachexia is associated with marked alterations in skeletal muscle protein metabolism that lead to muscle wasting and, in some cases, death. The inflammatory response elicited by cancer is a likely, if not primary, mediator of these alterations. This review focuses on the possible relationship between inflammatory signaling and altered amino acid
William J, Durham, Edgar Lichar, Dillon, Melinda, Sheffield-Moore   +2 more
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Sex Differences in Cumulative Exposure to Metabolic Risk Factors Before Hypertension Onset: The Cohort of the Tehran Lipid and Glucose Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background Previous studies have shown a sex difference in the association between hypertension and cardiovascular disease; however, the precise mechanism remains unclear.
Azra Ramezankhani, Fereidoun Azizi, Amir Abbas Momenan, Farzad Hadaegh   +3 more
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Strategic Optimization of CHO Cell Expression Platforms for Biopharmaceutical Manufacturing

Shengwu huaxue yu shengwu wuli jinzhan
Chinese hamster ovary (CHO) cells are the most established and versatile mammalian expression system for the large-scale production of recombinant therapeutic proteins, owing to their genetic stability, adaptability to serum-free suspension culture, and ...
ZHANG Rui-Ming, LI Meng-Lin, ZHU Hong-Wei, ZHANG Xing-Xiao   +3 more
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Metabolic syndrome and associated factors among severely ill psychiatric and non-psychiatric patients: a comparative cross-sectional study in Eastern Ethiopia

Diabetology & Metabolic Syndrome, 2021
Plain language summary Metabolic syndrome is a risk factor for cardiovascular disease that has public health issues, which places social, economic, and disease conditions in the community within the geographical region of sub-Saharan Africa, including ...
Dilnessa Fentie, Tariku Derese, Bekele Yazie, Yibeltal Getachew   +3 more
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