Results 41 to 50 of about 172,525 (164)

GLOMERULAR FILTRATION RATE (GFR) DETERMINES METABOLIC CLEARANCE RATE (MCR) OF HGH [PDF]

open access: yesPediatric Research, 1993
Top of pageAbstract Supraphysiological doses of rhGH are used for treatment of renal growth failure. Because of reduced renal MCR of rhGH this may result in accumulation of rhGH. To determine the quanlity of renal and extrarenal MCR of rhGH in chronic renal failure (CRF) we performed stepwise steady-state infusion studies of rhGH in 12 patients (pts ...
D Haffner   +4 more
openaire   +1 more source

An updated genome-scale metabolic network reconstruction of Pseudomonas aeruginosa PA14 to characterize mucin-driven shifts in bacterial metabolism

open access: yesnpj Systems Biology and Applications, 2021
Mucins are present in mucosal membranes throughout the body and play a key role in the microbe clearance and infection prevention. Understanding the metabolic responses of pathogens to mucins will further enable the development of protective approaches ...
Dawson D. Payne   +5 more
doaj   +1 more source

Metabolic and renal changes in patients with chronic hepatitis C infection after hepatitis C virus clearance by direct‐acting antivirals

open access: yesJGH Open, 2020
Background and Aim The impact of hepatitis C virus (HCV) clearance by direct‐acting antiviral agents (DAAs) on HCV‐related extrahepatic manifestations is not well known.
Riccardo Nevola   +8 more
doaj   +1 more source

Combined Effects of Temperature and Seston Concentration on the Physiological Energetics of the Manila Clam Ruditapes philippinarum. [PDF]

open access: yesPLoS ONE, 2016
The suspension-feeding Manila clam Ruditapes philippinarum is a native species of the western Pacific that is now widely distributed around the globe because of its commercial importance.
Hee Yoon Kang   +5 more
doaj   +1 more source

AMPK Modulates the Metabolic Adaptation of C6 Glioma Cells in Glucose-Deprived Conditions without Affecting Glutamate Transport

open access: yesCells, 2022
Energy homeostasis in the central nervous system largely depends on astrocytes, which provide metabolic support and protection to neurons. Astrocytes also ensure the clearance of extracellular glutamate through high-affinity transporters, which ...
Inês Belo do Nascimento   +7 more
doaj   +1 more source

Metabolic Clearance Rates, Production Rates and Concentrations of Progesterone in Pregnant Rhesus Monkeys [PDF]

open access: yesBiology of Reproduction, 1977
It has been reported of rhesus monkeys that uterine vein levels of progesterone decrease by 75% during the 2nd half of pregnancy while maternal peripheral vein levels remain fairly constant. Whether this difference could be explained by declining placental and/or ovarian progesterone production rates (PRs) occurring along with declining metabolic ...
R B, Thau, J T, Lanman, A O, Brinson
openaire   +2 more sources

Metabolic evaluation of first-time uncomplicated renal stone formers: A prospective study

open access: yesCurrent Urology, 2023
. Background. Nephrolithiasis is a global health problem. The recurrence rate after the first stone clearance is approximately 50% at 5 years. Metabolic abnormalities are an important factor responsible for stone recurrence.
Satish Kumar Ranjan   +7 more
doaj   +1 more source

Metabolic Clearance Rate of Rat Prolactin in Preweanling Rat Pups

open access: yesExperimental Biology and Medicine, 1983
The metabolic clearance rate (MCR) of immunoreactive rat prolactin (rPRL) was determined in urethane-anaesthetized 14 to 16-day-old rat pups using the constant infusion to equilibrium method. Two different doses of rPRL were used, 329 and 472 ng/min each at a volume of 0.0025 ml/min for 30 min.
A, de Bont, C E, Grosvenor
openaire   +2 more sources

Pharmacokinetic interaction study between ligustrazine and valsartan in rats and its potential mechanism

open access: yesPharmaceutical Biology, 2020
Context Ligustrazine and valsartan are commonly used drugs in the treatment of cardiac and cardiovascular disease. Objective The interaction between ligustrazine and valsartan was studied to investigate the effect of ligustrazine on the pharmacokinetics ...
Yang Liu, Jiaqi Zhang, Di Wu, Liran Cui
doaj   +1 more source

Metabolic clearance and production rates of prolactin in man. [PDF]

open access: yesJournal of Clinical Investigation, 1979
Metabolic clearance rates (MCR) and production rates (PR) of prolactin (PRL) have been determined by the constant infusion to equilibrium technique in 11 normal subjects, 6 patients with hyperthyroidism, 4 patients with hypothyroidism, and 9 patients with hyperprolactinemia. PRL MCR was also determined tin four patients during dopamine infusion.
D S, Cooper   +4 more
openaire   +2 more sources

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