Results 51 to 60 of about 726,001 (302)

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Mapping the Energetic Costs of Free-Swimming Gilthead Sea Bream (Sparus aurata), a Key Species in European Marine Aquaculture

Biology, 2021
Measurement of metabolic rates provides a valuable proxy for the energetic costs of different living activities. However, such measurements are not easy to perform in free-swimming fish. Therefore, mapping acceleration from accelerometer tags with oxygen
Sébastien Alfonso, Walter Zupa, Maria Teresa Spedicato, Giuseppe Lembo, Pierluigi Carbonara   +4 more
doaj   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Review of Lower-Limb (Quasi-)Passive Exoskeletons for Human Augmentation

IEEE Access
Researchers have been trying to develop lower-limb exoskeletons to reduce the metabolic cost for human augmentation. The research on (quasi-)passive exoskeletons has gained more widespread attention since the first passive ankle exoskeleton was ...
Tiancheng Zhou, Tianyun Li, Hongkuan Zhou, Wei Zheng   +3 more
doaj   +1 more source

Modeling and Prediction of Wearable Energy Harvesting Sliding Shoes for Metabolic Cost and Energy Rate Outside of the Lab

Sensors, 2020
The recent explosion of wearable electronics has led to widespread interest in harvesting human movement energy, particularly during walking, for clinical and health applications.
Peter B. Shull, Haisheng Xia
doaj   +1 more source

Macromolecular crowding explains overflow metabolism in cells [PDF]

, 2016
Overflow metabolism is a metabolic phenotype of cells characterized by mixed oxidative phosphorylation (OxPhos) and fermentative glycolysis in the presence of oxygen.
Oltvai, Zoltán N., Vazquez, Alexei
core   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Quantifying Demographic, Anthropometric, and Neurological Impairment Effects on Walking Performance in People With Spinal Cord Injury

IEEE Transactions on Neural Systems and Rehabilitation Engineering
Spinal cord injury (SCI) can impair sensorimotor pathways and reduce walking ability. The effects of sensorimotor impairments are complex, as they interact with other factors such as age, pain, injury level, and injury severity.
Minh Tat Nhat Truong, Emelie Butler Forslund, Ake Seiger, Elena M. Gutierrez-Farewik   +3 more
doaj   +1 more source

Systems biology of energetic and atomic costs in the yeast transcriptome, proteome, and metabolome [PDF]

, 2008
Proteins vary in their cost to the cell and natural selection may favour the use of proteins that are cheaper to produce. We develop a novel approach to estimate the amino acid biosynthetic cost based on genome-scale metabolic models, and directly ...
Balazs Papp, Casey M. Bergman, Daniel Delneri, Magnus Rattray, Michael D. Barton, Stephen G. Oliver   +5 more
core   +2 more sources

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source