Results 61 to 70 of about 345,589 (262)

The Energetics during the World's Most Challenging Mountain Ultra-Marathon—A Case Study at the Tor des Geants®

Frontiers in Physiology, 2017
Purpose: To provide insights into the energy requirements as well as the physiological adaptations of an experienced 50-year-old ultra-marathon male athlete during the world's most challenging mountain ultra-marathon (MUM).Methods: The international race
Aldo Savoldelli, Aldo Savoldelli, Alessandro Fornasiero, Alessandro Fornasiero, Pietro Trabucchi, Pietro Trabucchi, Eloisa Limonta, Antonio La Torre, Francis Degache, Francis Degache, Barbara Pellegrini, Barbara Pellegrini, Grégoire P. Millet, Gianluca Vernillo, Gianluca Vernillo, Federico Schena, Federico Schena   +16 more
doaj   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

The enzyme cost of metabolic fluxes

, 2023
This is a chapter from the free textbook "Economic Principles in Cell Biology" In this chapter we discuss why certain pathway designs have been selected by evolution, by hypothesizing that some are more beneficial than others – based on several possible criteria and optimization goals: minimizing the number of reactions, maximizing product yield ...
Liebermeister, Wolfram, Noor, Elad
openaire   +6 more sources

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Simulating Muscle-Level Energetic Cost When Humans Walk With a Passive Biarticular Thigh Exosuit

IEEE Transactions on Neural Systems and Rehabilitation Engineering
Passive exosuits offer potential for reducing the metabolic cost of walking, but evaluating their effectiveness is challenging due to difficulties in measuring internal biomechanics and muscle-level energetics.
Vahid Firouzi, Seungmoon Song, Oskar von Stryk, Andre Seyfarth, Maziar Ahmad Sharbafi   +4 more
doaj   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

How Gait Nonlinearities in Individuals Without Known Pathology Describe Metabolic Cost During Walking Using Artificial Neural Network and Multiple Linear Regression

Applied Sciences
This study uses Artificial Neural Networks (ANNs) and multiple linear regression (MLR) models to explore the relationship between gait dynamics and the metabolic cost.
Arash Mohammadzadeh Gonabadi, Farahnaz Fallahtafti, Judith M. Burnfield   +2 more
doaj   +1 more source