Results 161 to 170 of about 1,774 (249)

Clonal haematopoiesis in chronic lymphocytic leukaemia: Biology, inflammaging and clinical implications in the era of targeted therapy

Clinical and Translational Medicine, Volume 16, Issue 3, March 2026.
In an ageing and inflamed haematopoietic ecosystem, clonal haematopoiesis and chronic lymphocytic leukaemia may originate from shared or parallel stem cell clones. This interaction modulates the effects of targeted therapies and contributes to cytopenias, cardiovascular toxicity, therapy‐related myeloid neoplasms and Richter transformation.
Enrica Antonia Martino, Santino Caserta, Mamdouh Skafi, Maria Eugenia Alvaro, Antonella Bruzzese, Nicola Amodio, Eugenio Lucia, Virginia Olivito, Caterina Labanca, Francesco Mendicino, Ernesto Vigna, Fortunato Morabito, Massimo Gentile   +12 more
wiley   +1 more source

NMR-based metabolomics combined with metabolic pathway analysis reveals metabolic heterogeneity of colorectal cancer tissue at different anatomical locations and stages. [PDF]

Int J Cancer
Cai R, Ke L, Zhao Y, Zhao J, Zhang H, Zheng P, Xin L, Ma C, Lin Y.   +8 more
europepmc   +1 more source

Deregulated kynurenine metabolism – An alternate hypothesis for COVID-19 associated anosmia

Medical Hypotheses, 2021
openaire   +2 more sources

Pigmented Sorghum Phenolic Extracts Regulate the Expression of Cancer Development Pathway Genes in HT‐29 and Hypoxia‐Induced CCD 841 CoN Cells

Food Science &Nutrition, Volume 14, Issue 3, March 2026.
A depiction of reconstituted red sorghum and black sorghum extract effects on HT‐29 and CCD 841 CoN cell cells at 500 and 2000 μg/mL for 12 and 24 h resulting in the decrease of cancer cell viability, modulation of mutation‐associated genes, and suppression of hypoxia and metabolic signaling.
Aduba Collins, Kenneth Chinkwo, Nidhish Francis, Abishek Bommannan Santhakumar, Christopher Blanchard   +4 more
wiley   +1 more source

Transcriptomics insight into occupational exposure to engineered nanoparticles. [PDF]

Nanomedicine (Lond)
Simova Z, Sima M, Pelclova D, Klusackova P, Zdimal V, Schwarz J, Maskova L, Klema J, Dvorackova S, Rossner P, Rossnerova A.   +10 more
europepmc   +1 more source

Unraveling the role of TP53 mutations in myeloproliferative neoplasms: Molecular mechanisms of leukemic transformation

HemaSphere, Volume 10, Issue 3, March 2026.
Abstract TP53 mutations are found in over 50% of tumor types, including myeloproliferative neoplasms (MPNs). MPNs are characterized by a chronic phase, which may progress to secondary acute myeloid leukemia (sAML). Here, we discuss the physiological functions of p53 in hematopoiesis and its deregulation in MPNs.
Suzana da Silva‐Benedito, Paula Sabbo Bernardo, Jean‐Edouard Martin, Caroline Marty, Isabelle Plo, Iléana Antony‐Debré, Bárbara da Costa Reis Monte‐Mór   +6 more
wiley   +1 more source

Influence of Matcha and Tea Catechins on the Progression of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)-A Review of Patient Trials and Animal Studies. [PDF]

Nutrients
Kosik-Bogacka DI, Piotrowska K.
europepmc   +1 more source

Genetic and Transcriptomic Profiles Identify Potential Therapeutic Targets of Concurrent Follicular and Diffuse Large B‐Cell Lymphoma and Transformed Follicular Lymphoma

Hematological Oncology, Volume 44, Issue 2, March 2026.
ABSTRACT Concurrent follicular and diffuse large B‐cell lymphoma (FL/DLBCL) and transformed follicular lymphoma (tFL) are distinct B‐cell lymphoma entities, posing challenges for understanding pathogenesis and clinical management. The clinical characteristics of 98 FL/DLBCL, 31 tFL, 403 FL1‐2/3A, and 608 DLBCL patients were analyzed. DNA sequencing was
Rui Sun, Rui‐Chi Li, Hui‐Ying Li, Nan Wang, Tian‐Yuan Xu, Shuang Tian, Di Fu, Chen Li, Fang‐Yi Zhang, Yan Feng, Shu Cheng, Peng‐Peng Xu, Li Wang, Zhong Zheng, Wei‐Li Zhao   +14 more
wiley   +1 more source

Perturbation of the circadian clock in chronic diseases involving organ fibrosis. [PDF]

J Clin Invest
Mukherji A, Tharaux PL, Ray DW, Baumert TF.   +3 more
europepmc   +1 more source

A review of the impact of micro‐ and nanoplastics on female reproduction: What we know and gaps in knowledge

International Journal of Gynecology &Obstetrics, Volume 172, Issue 3, Page 1430-1436, March 2026.
Abstract Micro‐and nanoplastics (MNPs) are breakdown products of plastics, and humans are exposed to these particles through air, water, food, and soil. There is a growing concern that human exposure to MNPs negatively impacts health. In this review we will discuss the potential health impact of MNPs on ovarian function and the hypothalamic–pituitary ...
Sanchayana Raghuvir, Shawn Alex, Deborah Clegg   +2 more
wiley   +1 more source