Results 181 to 190 of about 1,944 (252)
CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 7, July 2026.ABSTRACT This work aims to assess the S65487‐induced disruption of the B‐cell lymphoma‐2 (Bcl2)/Bcl2‐like protein 11 (Bim) complex at therapeutic doses via a pharmacokinetic/pharmacodynamic model and to reconcile pharmacokinetic data from microdoses and therapeutic doses in a single population pharmacokinetic model. The first model consists of a linear
Chloé Burlot +6 more
wiley +1 more source
Meeting Report on the Symposium Organized to Celebrate the 40th Anniversary of the French Society for Cell Biology. [PDF]
Biol CellNiedergang F, Chabrier R, Tardieux I.
europepmc +1 more source
Small, Volume 22, Issue 37, 2 July 2026.This study establishes a human immunocompetent colitis‐on‐chip model that mimics inflamed gut mucosa and enables quantitative analysis of Candida albicans tissue invasion under DSS‐induced injury. It reveals that microbiota‐derived butyrate simultaneously stabilizes epithelial junctions and reprograms macrophages via HDAC/NLRP3‐dependent mechanisms ...
Manuel Allwang +16 more
wiley +1 more source
The Circadian Modulators as Molecular Targets in Cancer-A Review. [PDF]
Int J Mol SciWolniakowska A +3 more
europepmc +1 more source
Molecular Interplay of PARN and Telomerase: Tail Modifiers and Disease Implications
WIREs RNA, Volume 17, Issue 4, July/August 2026.Schematic representation of the molecular interplay between PARN, telomerase‐associated, and the involvement of p53 in regulating telomere maintenance and genome stability. The top panel shows how normal PARN levels are involved in regulating p53 levels and balanced telomerase activity through their regulatory interaction with TERC and TERRA, thus ...
Sujitha Felicitus +5 more
wiley +1 more source
A Narrative Review on Rodent Models of Neuropsychopathology Associated with Low Temperature Exposure. [PDF]
Neuropsychiatr Dis TreatPriya V, Ahmad F.
europepmc +1 more source
Aging Cell, Volume 25, Issue 7, July 2026.Primate‐specific lncRNA LINC01021 promotes aging by enhancing cellular senescence and accelerating aspects of organismal decline. Mechanistically, LINC01021 induces DAZAP1‐mediated destabilization of RBMX, activating the P53 pathway and establishing a primate‐specific regulatory axis in aging.
Yan Zhang +12 more
wiley +1 more source
Aging Cell, Volume 25, Issue 7, July 2026.This review systematically elucidates the multifactorial anti‐aging mechanisms of extracellular vesicles (EVs). By bridging fundamental biology with advanced bioengineering, scalable manufacturing, and clinical translation, it establishes a comprehensive framework for developing next‐generation EVs‐based precision nanotherapeutics to combat systemic ...
Xian Huang +6 more
wiley +1 more source
2-Hydroxyglutarate in onco-pathway: a metabolic driver of proto-oncogene activation. [PDF]
Front OncolThamim M +3 more
europepmc +1 more source
British Journal of Pharmacology, Volume 183, Issue 13, Page 3866-3884, July 2026.Abstract Background and Purpose The absence of the protein dystrophin in Duchenne muscular dystrophy (DMD) leads to progressive muscle weakness, failing regeneration and deregulation of nitric oxide (NO) signalling. We focused on L‐citrulline, a precursor of L‐arginine, required for NO production in muscle, which is reduced in dystrophic mdx muscle ...
Lisamaura Tulimiero +14 more
wiley +1 more source