Staging concept for aging management: Definition, mechanism, and coping strategies
We divided the overall aging stage into “pre‐aging”, “aging compensation”, and “aging disability”. For each stage, we delineate the clinical presentations, biological phenomena, theoretical underpinnings, and key management priorities. Abstract Aging, as a gradual and largely irreversible biological process, characterized by declining organismal ...
Zhonghan Wang +6 more
wiley +1 more source
Metabolic Transcriptional Activation in Ulcerative Colitis Identified Through scRNA-seq Analysis. [PDF]
Desterke C +3 more
europepmc +1 more source
ABSTRACT Type 2 diabetes mellitus (T2DM) is a central component of the metabolic syndrome (MetS) and is associated with underlying mitochondrial dysfunction. Disruption of mitochondrial homeostasis impairs cellular energy metabolism and contributes to the overproduction of reactive oxygen species (ROS), leading to oxidative stress, chronic inflammation,
Shanika Reddy +3 more
wiley +1 more source
Abstract Polybrominated diphenyl ethers (PBDEs) are neuroendocrine‐disrupting chemicals that produce adverse neurodevelopmental effects. PBDEs have been implicated as risk factors for autism spectrum disorder (ASD), which is characterized by abnormal psychosocial functioning and is commonly comorbid with cognitive deficits and sensory abnormalities ...
Elena V. Kozlova +28 more
wiley +1 more source
Sex-specific benefits of a combined supplementation of B vitamins, nicotinamide riboside, folate and cobalamin, in a murine model of heart failure. [PDF]
Boitard SE +12 more
europepmc +1 more source
Thioredoxin system modulates metabolic and stomatal responses to elevated CO2 in Arabidopsis
Integrative model of extraplastidial NADPH‐dependent thioredoxin reductase/thioredoxin system‐mediated regulation of stomatal function, redox homeostasis, and metabolic responses under ambient and elevated CO2 in Arabidopsis thaliana. Summary The NADPH‐dependent thioredoxin reductase/thioredoxin (NTR/TRX) system plays a central role in maintaining ...
Paula da Fonseca‐Pereira +11 more
wiley +1 more source
Metabolism fine tuning and cardiokines secretion represent adaptative responses of the heart to High Fat and High Sugar Diets in flies. [PDF]
Khamvongsa-Charbonnier L +9 more
europepmc +1 more source
Calcium and Nitrogen Availability Controls Root Exudation in Hydroponically Cultured Barley
ABSTRACT Root exudation is a key component of plant‐rhizosphere interactome. It is increasingly evident that root exudates influence rhizospheric microbial communities and in turn can benefit plants through improved resource allocation. However, how suboptimal nutrient availability relates to control of root exudation is poorly understood.
Ibadete Denjali +6 more
wiley +1 more source
Alterations in Cardiac Metabolism by <i>Trypanosoma cruzi</i> Infection: A Metabolomic Assessment by RPLC-MS and GC-MS. [PDF]
de Sá HC +7 more
europepmc +1 more source
Plants synthesize ergothioneine, showing a link to abiotic stress
Various plants possess ergothioneine biosynthetic genes and can synthesize this antioxidant, where increased EGT levels under abiotic stress conditions indicate protective functions. Abstract Ergothioneine (EGT) is a sulphur‐containing histidine derivative and a potent antioxidant that exhibits beneficial effects on human health.
C. Kock +3 more
wiley +1 more source

