Results 191 to 200 of about 1,944 (252)

Assessment of chemical risk factor for breast cancer based on gene expression profiles. [PDF]

Sci Rep
Achebouche R, Taboureau O.
europepmc   +1 more source

Updates on Mediterranean diet and health status: active ingredients and pharmacological mechanisms

British Journal of Pharmacology, Volume 183, Issue 13, Page 3484-3502, July 2026.
The Mediterranean diet (MedDiet) is among the most extensively studied dietary patterns and has been consistently associated with reduced risk of all‐cause mortality, cardiovascular disease, metabolic disorders, cognitive decline and several types of cancers.
Lukas Schwingshackl, Jakub Morze, Sabina Wallerer, Georg Hoffmann   +3 more
wiley   +1 more source

Single-cell genomics highlight MYC-associated metabolic activation and altered cell interactions in T-prolymphocytic leukemia progression. [PDF]

Nat Commun
Wahnschaffe L, Jungherz D, Müller TA, Pemovska T, Pichler A, Poulain S, Julia E, Timonen S, Böttcher M, Jiang Q, Beverungen D, Bischoff J, Franitza M, Georgomanolis T, Becker K, Hallek M, Mougiakakos D, Zenz T, Mustjoki S, Bachy E, Herbaux C, Schrader A, Pflug N, Staber PB, Braun T, Herling M.   +25 more
europepmc   +1 more source

Integrated miRNA–mRNA Analysis Reveals Obesity‐Driven Regulatory Networks in Human Visceral Adipose Tissue With and Without Type 2 Diabetes

Diabetes, Obesity and Metabolism, Volume 28, Issue 7, Page 5992-6008, July 2026.
ABSTRACT Aims Obesity is characterised by pathological alterations in visceral white adipose tissue (vWAT) that may contribute to the development of type 2 diabetes (T2D). While microRNAs (miRNAs) are key post‐transcriptional regulators, comprehensive human vWAT profiling across metabolic states remains limited.
Elsa Villa‐Fernández, Ana Victoria García, Laura Gallardo‐Nuell, Miguel García‐Villarino, Judit Fernández‐García, Aldara Martin Alonso, Claudia Lozano‐Aida, Lorena Suárez Gutiérrez, Pedro Pujante, Jessica Ares, Tomás González‐Vidal, Raquel Rodríguez Uría, Sandra Sanz Navarro, María Moreno Gijón, Lourdes María Sanz Álvarez, Estrella Olga Turienzo Santos, José Manuel Fernández‐Real, Mario Fernández Fraga, Elías Delgado, Carmen Lambert   +19 more
wiley   +1 more source

Targeting the microbiota‐miRNA‐protease axis: A new therapeutic avenue in melanoma

The FEBS Journal, Volume 293, Issue 13, Page 4043-4063, July 2026.
Modulation of extracellular matrix (ECM) turnover is central to melanoma progression and metastasis, driven largely by ECM proteases. This review highlights the epigenetic regulation of ECM proteases by microRNAs and their roles in melanoma growth, invasion, and immune modulation.
Elias N. Katsoulieris, Paraskevi Ioannou, Nikolaos A. Afratis   +2 more
wiley   +1 more source

Bcor loss promotes Richter transformation of chronic lymphocytic leukemia associated with Notch1 activation in mice. [PDF]

Leukemia
Rompietti C, Adamo FM, Sorcini D, De Falco F, Stella A, Martino G, Bigerna B, Dorillo E, Silva Barcelos EC, Esposito A, Geraci C, Arcaleni R, Bordini J, Scarfò L, Rosati E, Ghia P, Falini B, Sportoletti P.   +17 more
europepmc   +1 more source

Neural Organoid Models as a Platform for Studying Disease Mechanisms in Amyotrophic Lateral Sclerosis

Journal of Neurochemistry, Volume 170, Issue 7, July 2026.
Amyotrophic lateral sclerosis (ALS) involves widespread cortical pathology beyond the motor cortex. Human‐induced pluripotent stem cell‐derived neural organoids model cortical tissue in vitro and provide a physiologically relevant platform to study disease mechanisms in ALS.
Kristel N. Eigenhuis, Roberto Montoro Ferrer, R. Jeroen Pasterkamp   +2 more
wiley   +1 more source

Fibroblast growth factor 23 as a risk factor for incident diabetes. [PDF]

Curr Opin Nephrol Hypertens
de Borst MH.
europepmc   +1 more source

Synthesis and Evaluation of Novel Cinnamic Acid Hybrids With Antiacetylcholinesterase, Antioxidant, and Anti‐Inflammatory Properties

ChemMedChem, Volume 21, Issue 11, 15 June 2026.
In this work, we identified two novel pleiotropic sinapic acid derivatives with excellent anti‐acetylcholinesterase, antioxidant, and anti‐inflammatory properties. Alzheimer's disease, one of the most widespread neurodegenerative disorders, is known for its multifactorial nature that makes it challenging to treat.
Konstantina Sdougkou, Eleni Rekka, Dionysia Papagiannopoulou   +2 more
wiley   +1 more source

Transcriptomic analysis reinforces the implication of spatacsin in neuroinflammation and neurodevelopment. [PDF]

Sci Rep
Toupenet Marchesi L, Stockholm D, Esteves T, Leblanc M, Auger N, Branchu J, El Hachimi KH, Stevanin G.   +7 more
europepmc   +1 more source