Results 171 to 180 of about 1,944 (252)

Epigenetic and metabolic rewiring in metastatic pheochromocytomas and paragangliomas driven by SDHB mutations. [PDF]

Commun Biol
Cubiella T, Alba-Linares JJ, San-Juan-Guardado J, Suarez-Priede A, Gómez-Suárez N, Tous M, Bancos I, Villabona C, Serrano T, Tena I, Del Olmo M, Forga L, Valdés N, Fraga MF, Chiara MD.   +14 more
europepmc   +1 more source

Multiple myeloma: A tale of deregulated transcription factors

HemaSphere, Volume 10, Issue 7, July 2026.
Abstract A comprehensive understanding of the molecular mechanisms underlying multiple myeloma (MM) pathogenesis is essential for developing therapeutic strategies that overcome disease heterogeneity and treatment relapse. In this review, we focus on transcription factors (TFs), key regulators of gene expression that play critical roles in normal ...
Nahia Gómez‐Echarte, Edurne San José‐Enériz, Estíbaliz Urizar‐Compains, Paula Rodriguez‐Otero, Felipe Prósper, Xabier Agirre   +5 more
wiley   +1 more source

Regulation of Ferroptosis Sensitivity in Hepatocellular Carcinoma Cells by Lysosomal Ion Channels TPC2 and TRPML1. [PDF]

Antioxidants (Basel)
Geisslinger F, Gell V, Witt F, Jaślan D, Grimm C, Koeberle A, Bartel K.   +6 more
europepmc   +1 more source

Integrative Transcriptomic and Functional Analysis of PKMYT1 Reveals a Potential Therapeutic Target in Chronic Lymphocytic Leukemia

Hematological Oncology, Volume 44, Issue 4, July 2026.
ABSTRACT Chronic lymphocytic leukemia (CLL) is a clinically and molecularly heterogeneous disease. PKMYT1, a G2/M cell cycle kinase, has been implicated in tumor progression in several cancers, but its role in CLL remains unclear. We evaluated PKMYT1 expression in primary CLL samples and analyzed associations with cytogenetic features and clinical ...
Elizabete Cristina Iseke Bispo, Cláudia de Souza Lima Pontes, Jennifer Martins do Nascimento, Fábio Wilson de Lima Alves, Juliana Lott de Carvalho, Antônio Roberto Lucena‐Araujo, Felipe Saldanha‐Araujo   +6 more
wiley   +1 more source

Psoriasis, stem cells, and obesity: metabolic exploration for therapeutics. [PDF]

J Med Life
Constantin C, Dobre EG, Munteanu AN, Surcel M, Căruntu C, Zurac SA, Neagu M.   +6 more
europepmc   +1 more source

Salvia officinalis flowers extract ameliorates liver and kidney injuries induced by simultaneous intoxication with ethanol/castor oil. [PDF]

Physiol Rep, 2023
Jedidi S, Rtibi K, Selmi H, Aloui F, Sebai H.   +4 more
europepmc   +1 more source

Urologic Bacteriome: The Hero or the Villain in Prostate Cancer Onset, Progression, and Treatment?

Medicinal Research Reviews, Volume 46, Issue 4, Page 1111-1151, July 2026.
ABSTRACT Prostate cancer (PCa) is the second most frequently diagnosed cancer in men worldwide and the fifth leading cause of cancer‐related mortality, presenting urgent unmet clinical needs in diagnosis and treatment. The recognition of the microbiome as a key factor in human health has prompted numerous studies, revealing an exciting new approach to ...
Lara R. S. Fonseca, Mariana Feijó, Cátia V. Vaz, Bruno J. Pereira, Sandra Laurentino, Ana Palmeira‐de‐Oliveira, Sílvia Socorro   +6 more
wiley   +1 more source

PCSK7 levels in women with and without PCOS. [PDF]

J Clin Transl Endocrinol
Atkin SL, Butler AE, Jamialahmadi T, Sahebkar A.   +3 more
europepmc   +1 more source

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, Volume 46, Issue 4, Page 1173-1229, July 2026.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

Diagnostic and Clinical Significance of the Special AT-Rich Sequence-Binding Protein 2 Deregulation in Gastrointestinal Malignancies. [PDF]

Maedica (Bucur)
Davris D, Falidas E, Adamopoulou M, Tsiambas E, Metaxas IE, Poultsidi A, Tzovaras G, Zacharoulis D.   +7 more
europepmc   +1 more source