Results 161 to 170 of about 1,944 (252)

Physiology Reimagined: Molecular, Metabolic, and Microenvironmental Forces Driving Epithelial Cancers. [PDF]

Curr Issues Mol Biol
Scheau C, Caruntu A.
europepmc   +1 more source

Systemic and Local Adiposity in the Bone Marrow Microenvironment Associated With Improved Prognosis in Hodgkin Lymphoma: Imaging and Molecular Analysis

International Journal of Cancer, Volume 159, Issue 3, Page 782-796, 1 August 2026.
Schematic overview of systemic and bone marrow‐specific adiposity in Hodgkin Lymphoma (HL). Body Mass Index was associated with bone marrow (BM) involvement, relapse, and mortality (1). In contrast, increased yellow marrow density was associated with poorer prognosis (2).
Andreia Matos, William P. Cawthorn, Joana Marinho‐Dias, Sofia Ramalheira, Susana Roncon, Dulcineia Pereira, Teresa Ribeiro, Carla Rodrigues, Mário Mariz, Ana Miranda, Helena Brízido, Manuel Bicho, Pedro Medeiros, Ana Carneiro, Fernanda Trigo, Pingzhao Hu, Flávia Pereira, Hugo Duarte, Calum D. Gray, Tom Macgillivray, Alan G. Ramsay, Maria J. Oliveira, Ricardo Ribeiro   +22 more
wiley   +1 more source

Metabolic and epigenetic interplay in HSPC specification: A balance between extrinsic and intrinsic cues. [PDF]

iScience
Kalogeraki M, Rondeau V, Abou Nader Z, Espéli M, Balabanian K.   +4 more
europepmc   +1 more source

Mutations in tumor suppressor p53 and deregulation of cellular metabolism

, 2018
Mutation of the p53 gene is the most common genetic alteration among all human cancers. Prevalent p53 missense mutations abrogate its tumor suppressive function and lead to gain-of-function properties that promote cancer cell proliferation, chemoresistance, angiogenesis, migration, invasion, and metastasis.
openaire   +1 more source

Oestrogen receptor phosphorylation profiles and in silico PAM50 subtyping reflect sexual dimorphism in breast cancer

The Journal of Pathology: Clinical Research, Volume 12, Issue 4, July 2026.
Abstract Breast cancer (BC) is most prevalent in females but also accounts for <1% of male cancer cases and 0.2% of male cancer‐related deaths. Distribution of histological subtypes, receptor status, and age of diagnosis varies based on sex, and a growing body of evidence supports sex‐specific molecular differences in BC.
Subarnarekha Chatterji, Aimee Diack, Marcin Szostok, Michael D Morgan, Valentina Silvestri, Laura Ottini, Cathy B Moelans, Paul J van Diest, Cigdem Selli, Andrew H Sims, Rasha Abu‐Eid, Valerie Speirs   +11 more
wiley   +1 more source

Proteome-scale autoantibody profiling in PSC: Associations with clinical phenotypes and evidence for neuroendocrine deregulations. [PDF]

JHEP Rep
Cornillet M, Båve AL, Sun D, Nouairia G, Villard C, Grigoriadis A, von Seth E, Jansson H, Álvez MB, Bergström S, Nilsson P, Uhlén M, Edfors F, Stål P, SweHep consortium, Sparrelid E, Björkström NK, Halfvarson J, Bergquist A.   +18 more
europepmc   +1 more source

Fat Checking: Emerging Role of Lipids in Metabolism and Disease. [PDF]

Int J Mol Sci, 2022
Segatto M, Cutone A, Pallottini V.
europepmc   +1 more source

Cholesterol‐Lowering Treatment Blocks Epithelial‐Mesenchymal Transition (EMT) Associated Invasiveness and Drug Resistance in Breast and Colorectal Adenocarcinoma Models

Cancer Medicine, Volume 15, Issue 7, July 2026.
ABSTRACT Background Epithelial‐mesenchymal transition (EMT) is a cellular process involved in the invasion and metastasis of cancer cells. Deregulated cellular cholesterol is associated with treatment resistance and metastatic potential in cancer cells; however, the link between EMT and cholesterol is unclear.
Shanen Perumal, Naaziyah Abdulla, Ruth Aronson, Mandeep Kaur   +3 more
wiley   +1 more source

Maternal emulsifier consumption alters the offspring early-life microbiota and goblet cell function leading to long-lasting diseases susceptibility. [PDF]

Nat Commun
Delaroque C, Rytter H, Bonazzi E, Huillet M, Ellero-Simatos S, Chatonnat E, Hao F, Patterson A, Chassaing B.   +8 more
europepmc   +1 more source

Therapeutic Potential of Carica papaya (L.) Extract on NRF2/KEAP1 and Apoptotic Pathways in Asbestos‐Induced Lung Toxicity

Food Science &Nutrition, Volume 14, Issue 7, July 2026.
Asbestos exposure induced oxidative stress, apoptosis, and lung tissue damage in animal models. Treatment with Carica papaya (500 mg/kg) extract improved antioxidant status, reduced oxidative stress biomarkers, and restored lung architecture. Gene expression analysis showed modulation of NRF2/KEAP1 and apoptotic pathways.
Usman Haider, Muhammad Ahmad, Wania Nasir, Najeeb Ullah Khan, Muhammad Saad Tariq, Bilal Aslam, Saif Ur Rehman, Junming Sun   +7 more
wiley   +1 more source