Results 191 to 200 of about 1,774 (249)

Haematological, Biochemical and Acid‐Base Changes in Uraemic Dogs Undergoing Intermittent Haemodialysis (2017–2024)

Veterinary Medicine and Science, Volume 12, Issue 2, March 2026.
This study investigated the laboratory variables of uraemic crisis dogs undergoing intermittent haemodialysis (IHD). The documented laboratory changes support early therapeutic planning. Acid‐base correction and toxin removal highlight the efficacy of IHD, while the progression of anaemia and hypoalbuminaemia requires continued monitoring.
Diego Ribeiro, Reiner S. de Moraes, Silvano S. Geraldes, Henry D. Mogollón‐García, Paulo F. Marcusso, Alessandra Melchert, Adriano S. Okamoto, Priscylla T. C. Guimarães‐Okamoto   +7 more
wiley   +1 more source

Single-cell RNAseq reveals adverse metabolic transcriptional program in intrahepatic cholangiocarcinoma malignant cells. [PDF]

Biochem Biophys Rep
Desterke C, Francés R, Monge C, Fu Y, Marchio A, Pineau P, Mata-Garrido J.   +6 more
europepmc   +1 more source

Intergenerational Transmission of Metabolic Changes in Oocytes From Aged Mice

Aging Cell, Volume 25, Issue 3, March 2026.
This study shows that oxidative changes in oocytes from aged female mice lead to lipid droplet accumulation and altered energy and retinoid metabolism. These changes persist in embryonic organs, triggering antioxidant responses in lipid‐rich tissues. Remarkably, altered profiles are transmitted across generations, reaching third generation, suggesting ...
Hafsa Gulzar, Richard Musson, Simona Bisogno, Lulu Alluhaibi, Alexey Maximenko, Ewelina Bik, Małgorzata Barańska, Joanna Depciuch, Grażyna E. Ptak   +8 more
wiley   +1 more source

Targeting sphingolipid metabolism: inhibition of neutral sphingomyelinase 2 impairs coronaviral replication organelle formation. [PDF]

mBio
Salisch F, Schumacher F, Gärtner U, Kleuser B, Ziebuhr J, Müller-Ruttloff C.   +5 more
europepmc   +1 more source

Heat‐Not‐Burn Tobacco Aerosols Induce Immune Dysregulation and Barrier Disruption Comparable to Conventional Cigarettes

Allergy, Volume 81, Issue 3, Page 781-795, March 2026.
Comparative analysis between cigarette smokers and HnB users revealed similar inflammatory lung function parameters and immunophenotypic patterns. Cigarette smoke and HnB aerosol had an impact on ECM through divergent downstream pathways. Exposed to Cigarette smoke and HnB aerosol caused comparative TJ weakening in the epithelial barrier.
Dilara Karaguzel, Alicja Walewska, Basak Ezgi Sarac, Marlena Tynecka, Kinga Bondarczuk, Agnieszka Tarasik, Dariusz Kisiel, Karolina Partyk, Damian Pogodziński, Bartosz Hanczaruk, Alicja Toczydlowska, Cagla Bicakci, Doga Oztabak, Magdalena Niemira, Adam Kretowski, Marlena Dubatowka, Natalia Ogrodnik, Malgorzata Chlabicz, Pawel Sowa, Karol Kaminski, Marcin Moniuszko, Andrzej Eljaszewicz, Cagatay Karaaslan   +22 more
wiley   +1 more source

Investigating the Origins of Biochemical Dysregulation in Trisomy 21 Pregnancy.

J Clin Endocrinol Metab
Buczyńska A, Sidorkiewicz I, Krętowski AJ, Zbucka-Krętowska M.   +3 more
europepmc   +1 more source

<b>MBRA 3.0: integrating the mucus environment for advanced high-throughput</b> <i><b>in vitro</b></i> <b>intestinal microbiome modeling</b>. [PDF]

Gut Microbes
Duquesnoy M, Chassaing B.
europepmc   +1 more source

Transcriptional and functional effects of mavacamten in multiple porcine and human models with hypertrophic cardiomyopathy

British Journal of Pharmacology, Volume 183, Issue 5, Page 1122-1139, March 2026.
Abstract Background and Purpose Mavacamten (MAVA) is a novel small molecule inhibitor of cardiac myosin, mitigating cardiomyocyte hypercontractility in patients with hypertrophic obstructive cardiomyopathy (HOCM). Despite its recent approval for clinical use, the transcriptional and functional impacts of MAVA remain not well understood.
Elisa Kiselev, Wilson Agyapong, Bjarne Jürgens, Elisa Mohr, Shambhabi Chatterjee, Hannah J. Hunkler, Jawad Salman, Giuseppe Cipriano, Marco Bentele, Junqing Liu, Jonas Specht, Kaja S. Menge, Florian J. G. Waleczek, Jonas A. Haas, Anselm A. Derda, Kristina Sonnenschein, Anika Gietz, Susanne Neumüller, Angelika Pfanne, Oliver Beetz, Michael Pflaum, Bettina Wiegmann, Yiangos Psaras, Christopher Toepfer, Robert Zweigerdt, Ante Radocaj, Theresia Kraft, Andre Zeug, Evgeni Ponimaskin, Wilhelm Korte, Alexander Horke, Arjang Ruhparwar, Maximilian Fuchs, Ke Xiao, Christian Bär, Natalie Weber, Thomas Thum   +36 more
wiley   +1 more source

Neural stem cells fate under neuroinflammatory conditions and oxidative stress response. [PDF]

Front Cell Neurosci
Torrisi F, Denaro S, Ragonese J, D'Aprile S, Zappalà A, Parenti R.   +5 more
europepmc   +1 more source

RB1 inactivation in cutaneous carcinomas

Histopathology, Volume 88, Issue 4, Page 769-789, March 2026.
Among skin carcinomas, recurrent RB1 inactivation is observed in Merkel cell carcinoma, in a subset of squamous cell carcinoma with bowenoid morphology, in sebaceous carcinoma and in the recently described Wnt/beta‐catenin rosette‐forming carcinoma.
Tiffany Liv, Antoine Touzé, David Schrama, Serge Guyétant, Mahtab Samimi, Michael T Tetzlaff, Benjamin A Wood, Paul W Harms, Thibault Kervarrec   +8 more
wiley   +1 more source