Results 51 to 60 of about 1,944 (252)
Metabolic Transcriptional Activation in Ulcerative Colitis Identified Through scRNA-seq Analysis. [PDF]
Genes (Basel)Background: Ulcerative colitis is a chronic inflammatory disease affecting the colon. During chronic inflammation of epithelial cells, lipid metabolism via pro-inflammatory eicosanoids is known to modify the immune response.
Desterke C +3 more
europepmc +2 more sources
Mitochondria Deregulations in Cancer Offer Several Potential Targets of Therapeutic Interventions [PDF]
, 2023 Mitochondria play a key role in cancer and their involvement is not limited to the production of ATP only. Mitochondria also produce reactive oxygen species and building blocks to sustain rapid cell proliferation; thus, the deregulation of mitochondrial ...
Clara Musicco +4 more
core +1 more source
[Hypothalamic inflammation and energy balance deregulations: Focus on chemokines.].
, 2016 The hypothalamus is a key brain region in the regulation of energy balance. It especially controls food intake and both energy storage and expenditure through integration of humoral, neural and nutrient-related signals and cues.
Carole Rovère +3 more
core +1 more source
Microbiology Spectrum, 2022 Evidence is accumulating that plant viruses alter host plant traits in ways that modify their insect vectors’ behavior. These alterations often enhance virus transmission, which has led to the hypothesis that these effects are manipulations caused by ...
Quentin Chesnais +6 more
doaj +1 more source
MaREA: Metabolic feature extraction, enrichment and visualization of RNAseq data
, 2018 The characterization of the metabolic deregulations that distinguish cancer phenotypes, and which might be effectively targeted by ad-hoc strategies, is a key open challenge.
Claudio Isella +7 more
core +1 more source
Triptolide Administration Alters Immune Responses to Mitigate Insulin Resistance in Obese States
BiomoleculesIndividuals who are overweight or obese are at increased risk of developing prediabetes and type 2 diabetes, yet the direct molecular mechanisms that connect diabetes to obesity are not clear.
Lyudmila Grodsky +3 more
doaj +1 more source
BMC Genomics, 2023 Background In breast cancer, as in all cancers, genetic and epigenetic deregulations can result in out-of-context expressions of a set of normally silent tissue-specific genes.
Emmanuelle Jacquet +7 more
doaj +1 more source
Deregulated Myc Requires MondoA/Mlx for Metabolic Reprogramming and Tumorigenesis [PDF]
Cancer Cell, 2015 Deregulated Myc transcriptionally reprograms cell metabolism to promote neoplasia. Here we show that oncogenic Myc requires the Myc superfamily member MondoA, a nutrient-sensing transcription factor, for tumorigenesis. Knockdown of MondoA, or its dimerization partner Mlx, blocks Myc-induced reprogramming of multiple metabolic pathways, resulting in ...
Carroll, Patrick A. +12 more
openaire +2 more sources
Cancer Cell International, 2021 Type 2 diabetes mellitus and breast cancer are complex, chronic, heterogeneous, and multi-factorial diseases; with common risk factors including but not limited to diet, obesity, and age. They also share mutually inclusive phenotypic features such as the
Ilhaam Ayaz Durrani +2 more
doaj +1 more source
Metabolic Deregulation of the Blood-Outer Retinal Barrier in Retinitis Pigmentosa [PDF]
Cell Reports, 2019 Retinitis pigmentosa (RP) initiates with diminished rod photoreceptor function, causing peripheral and night-time vision loss. However, subsequent loss of cone function and high-resolution daylight and color vision is most debilitating. Visual pigment-rich photoreceptor outer segments (OS) undergo phagocytosis by the retinal pigment epithelium (RPE ...
Wei Wang +19 more
openaire +3 more sources