Results 41 to 50 of about 1,794 (242)

Triptolide Administration Alters Immune Responses to Mitigate Insulin Resistance in Obese States

Biomolecules
Individuals who are overweight or obese are at increased risk of developing prediabetes and type 2 diabetes, yet the direct molecular mechanisms that connect diabetes to obesity are not clear.
Lyudmila Grodsky, Mickey Wilson, Thirumurugan Rathinasabapathy, Slavko Komarnytsky   +3 more
doaj   +1 more source

Comparative Plant Transcriptome Profiling of Arabidopsis thaliana Col-0 and Camelina sativa var. Celine Infested with Myzus persicae Aphids Acquiring Circulative and Noncirculative Viruses Reveals Virus- and Plant-Specific Alterations Relevant to Aphid Feeding Behavior and Transmission

Microbiology Spectrum, 2022
Evidence is accumulating that plant viruses alter host plant traits in ways that modify their insect vectors’ behavior. These alterations often enhance virus transmission, which has led to the hypothesis that these effects are manipulations caused by ...
Quentin Chesnais, Victor Golyaev, Amandine Velt, Camille Rustenholz, Véronique Brault, Mikhail M. Pooggin, Martin Drucker   +6 more
doaj   +1 more source

Metabolic programming a lean phenotype by deregulation of RNA polymerase III [PDF]

Proceedings of the National Academy of Sciences, 2018
Significance As a repressor of transcription by RNA polymerase (Pol) III, Maf1 is thought to play an important role in the energetic economy of cells by controlling the synthesis of highly abundant tRNAs and 5S rRNA.
Ian M. Willis, Robyn D. Moir, Nouria Hernandez   +2 more
openaire   +3 more sources

Aberrant activation of five embryonic stem cell-specific genes robustly predicts a high risk of relapse in breast cancers

BMC Genomics, 2023
Background In breast cancer, as in all cancers, genetic and epigenetic deregulations can result in out-of-context expressions of a set of normally silent tissue-specific genes.
Emmanuelle Jacquet, Florent Chuffart, Anne-Laure Vitte, Eleni Nika, Mireille Mousseau, Saadi Khochbin, Sophie Rousseaux, Ekaterina Bourova-Flin   +7 more
doaj   +1 more source

The prognostic outcome of ‘type 2 diabetes mellitus and breast cancer’ association pivots on hypoxia-hyperglycemia axis

Cancer Cell International, 2021
Type 2 diabetes mellitus and breast cancer are complex, chronic, heterogeneous, and multi-factorial diseases; with common risk factors including but not limited to diet, obesity, and age. They also share mutually inclusive phenotypic features such as the
Ilhaam Ayaz Durrani, Attya Bhatti, Peter John   +2 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Deregulated Myc Requires MondoA/Mlx for Metabolic Reprogramming and Tumorigenesis [PDF]

Cancer Cell, 2015
Deregulated Myc transcriptionally reprograms cell metabolism to promote neoplasia. Here we show that oncogenic Myc requires the Myc superfamily member MondoA, a nutrient-sensing transcription factor, for tumorigenesis. Knockdown of MondoA, or its dimerization partner Mlx, blocks Myc-induced reprogramming of multiple metabolic pathways, resulting in ...
Carroll, Patrick A., Diolaiti, Daniel, McFerrin, Lisa, Gu, Haiwei, Djukovic, Danijel, Du, Jianhai, Cheng, Pei Feng, Anderson, Sarah, Ulrich, Michelle, Hurley, James B., Raftery, Daniel, Ayer, Donald E., Eisenman, Robert N.   +12 more
openaire   +2 more sources

Dual-mTOR Inhibitor Rapalink-1 Reduces Prostate Cancer Patient-Derived Xenograft Growth and Alters Tumor Heterogeneity

Frontiers in Oncology, 2020
Bone metastasis is the leading cause of prostate cancer (PCa) mortality, frequently marking the progression to castration-resistant PCa. Dysregulation of the androgen receptor pathway is a common feature of castration-resistant PCa, frequently appearing ...
Federico La Manna, Federico La Manna, Marta De Menna, Nikhil Patel, Sofia Karkampouna, Maria De Filippo, Maria De Filippo, Irena Klima, Peter Kloen, Lijkele Beimers, George N. Thalmann, Rob C. M. Pelger, Estela Jacinto, Marianna Kruithof-de Julio, Marianna Kruithof-de Julio   +14 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Investigating the deregulation of metabolic tasks via Minimum Network Enrichment Analysis (MiNEA) as applied to nonalcoholic fatty liver disease using mouse and human omics data.

PLoS Computational Biology, 2019
Nonalcoholic fatty liver disease (NAFLD) is associated with metabolic syndromes spanning a wide spectrum of diseases, from simple steatosis to the more complex nonalcoholic steatohepatitis.
Vikash Pandey, Vassily Hatzimanikatis
doaj   +1 more source