Results 41 to 50 of about 1,944 (252)
CHTM1, a novel metabolic marker deregulated in human malignancies [PDF]
Oncogene, 2018 A better understanding of the link between cellular metabolism and tumorigenesis is needed. Here, we report characterization of a novel protein named coiled-coil helix tumor and metabolism 1 (CHTM1). We have found that CHTM1 is associated with cancer and cellular metabolism.
Babbar, Mansi +4 more
openaire +2 more sources
, 2023 Mood disorders, and in particular depression, are a major burden on society. To improve therapeutic strategies it is vital to better characterize their underlying pathophysiology and to identify reliable biological markers.
Antoine Cherix +8 more
core +1 more source
Immunometabolism features of metabolic deregulation and cancer
Journal of Cellular and Molecular Medicine, 2018 AbstractImmunometabolism is a branch dealing at the interface of immune functionalities and metabolic regulations. Considered as a bidirectional trafficking, metabolic contents and their precursors bring a considerable change in immune cells signal transductions which as a result affect the metabolic organs and states as an implication. Lipid metabolic
Xue Wang +4 more
openaire +2 more sources
Deregulated Lysophosphatidic Acid Metabolism and Signaling in Liver Cancer [PDF]
Cancers, 2019 Liver cancer is one of the leading causes of death worldwide due to late diagnosis and scarcity of treatment options. The major risk factor for liver cancer is cirrhosis with the underlying causes of cirrhosis being viral infection (hepatitis B or C), metabolic deregulation (Non-alcoholic fatty liver disease (NAFLD) in the presence of obesity and ...
Eleanna Kaffe +2 more
openaire +2 more sources
Deregulation of RNA Metabolism in Microsatellite Expansion Diseases [PDF]
, 2018 RNA metabolism impacts different steps of mRNA life cycle including splicing, polyadenylation, nucleo-cytoplasmic export, translation, and decay. Growing evidence indicates that defects in any of these steps lead to devastating diseases in humans. This chapter reviews the various RNA metabolic mechanisms that are disrupted in Myotonic Dystrophy-a ...
Chaitali, Misra +2 more
openaire +2 more sources
Formation of benign tumors by stem cell deregulation.
PLoS Genetics, 2022 Within living organisms, stem cells respond to various cues, including to niche signals and growth factors. Niche signals originate from the stem cell's microenvironment and promote the undifferentiated state by preventing differentiation, allowing for ...
Matthieu Valet, Patrick Narbonne
doaj +1 more source
Biomarkers of stress-mediated metabolic deregulation in diabetes mellitus [PDF]
Diabetes Research and Clinical Practice, 2017 Cette revue illustre la relation entre le stress oxydatif et nitratif et le diabète sucré et ses complications. Ceci est d'un intérêt considérable car le diabète sucré est une maladie métabolique systémique à vie qui peut survenir pendant l'enfance ou l'âge adulte et affecte non seulement une triade d'insuline des cellules des îlots pancréatiques, d ...
Dina Johar, Larry Bernstein
openaire +3 more sources
, 2023 The direct relationship between facilitative glucose transporters (GLUTs) and metabolic diseases opens new avenues for sensing metabolic deregulations and drives the development of molecular probes for GLUT-targeted detection of metabolic diseases ...
Nyansa, Monica Mame +10 more
core +2 more sources
Molecules, 2021 Metabolic disorders often lead to cardiac complications. Metabolic deregulations during diabetic conditions are linked to mitochondrial dysfunctions, which are the key contributing factors in cardiac hypertrophy.
Iram Mushtaq +12 more
doaj +1 more source
MiR-22 Deficiency Fosters Hepatocellular Carcinoma Development in Fatty Liver
Cells, 2022 MiR-22 is mostly considered as a hepatic tumor-suppressor microRNA based on in vitro analyses. Yet, whether miR-22 exerts a tumor-suppressive function in the liver has not been investigated in vivo.
Monika Gjorgjieva +9 more
doaj +1 more source