Results 21 to 30 of about 1,794 (242)

Targeting Metabolic Deregulation Landscapes in Breast Cancer Subtypes [PDF]

Frontiers in Oncology, 2020
Metabolic deregulation is an emergent hallmark of cancer. Altered patterns of metabolic pathways result in exacerbated synthesis of macromolecules, increased proliferation, and resistance to treatment via alteration of drug processing. In addition, molecular heterogeneity creates a barrier to therapeutic options.
Erandi A. Serrano-Carbajal, Jesús Espinal-Enríquez, Jesús Espinal-Enríquez, Enrique Hernández-Lemus, Enrique Hernández-Lemus   +4 more
openaire   +3 more sources

Metabolic Alterations Identified in Urine, Plasma and Aortic Smooth Muscle Cells Reflect Cardiovascular Risk in Patients with Programmed Coronary Artery Bypass Grafting

Antioxidants, 2021
Atherosclerosis is the predominant pathology associated to premature deaths due to cardiovascular disease. However, early intervention based on a personalized diagnosis of cardiovascular risk is very limited.
Aranzazu Santiago-Hernandez, Paula J. Martinez, Marta Agudiez, Angeles Heredero, Laura Gonzalez-Calero, Alma Yuste-Montalvo, Vanesa Esteban, Gonzalo Aldamiz-Echevarria, Marta Martin-Lorenzo, Gloria Alvarez-Llamas   +9 more
doaj   +1 more source

Deregulation of Lipid Metabolism: The Critical Factors in Ovarian Cancer [PDF]

Frontiers in Oncology, 2020
Ovarian cancer is one of the most malignant gynecological cancers around the world. In spite of multiple treatment options, the five-year survival rate is still very low. Several metabolism alterations are described as a hallmark in cancers, but alterations of lipid metabolism in ovarian cancer have been paid less attention.
Zhaodong Ji, Zhaodong Ji, Yan Shen, Xu Feng, Xu Feng, Yue Kong, Yue Kong, Yang Shao, Yang Shao, Jiao Meng, Jiao Meng, Xiaofei Zhang, Gong Yang, Gong Yang, Gong Yang   +14 more
openaire   +3 more sources

Muscle and Bone Impairment in Infantile Nephropathic Cystinosis: New Concepts

Cells, 2022
Cystinosis Metabolic Bone Disease (CMBD) has emerged during the last decade as a well-recognized, long-term complication in patients suffering from infantile nephropathic cystinosis (INC), resulting in significant morbidity and impaired quality of life ...
Dieter Haffner, Maren Leifheit-Nestler, Candide Alioli, Justine Bacchetta   +3 more
doaj   +1 more source

Mass Spectrometry-Based Peptide Profiling of Haemolymph from Pterostichus melas Exposed to Pendimethalin Herbicide

Molecules, 2022
Pendimethalin-based herbicides are used worldwide for pre-emergence selective control of annual grasses and weeds in croplands. The endurance of herbicides residues in the environment has an impact on the soil biodiversity and fertility, also affecting ...
Donatella Aiello, Anita Giglio, Federica Talarico, Maria Luigia Vommaro, Antonio Tagarelli, Anna Napoli   +5 more
doaj   +1 more source

Deregulated Metabolic Pathways in Ovarian Cancer: Cause and Consequence

Metabolites, 2023
Ovarian cancers are tumors that originate from the different cells of the ovary and account for almost 4% of all the cancers in women globally. More than 30 types of tumors have been identified based on the cellular origins. Epithelial ovarian cancer (EOC) is the most common and lethal type of ovarian cancer which can be further divided into high-grade
Roopak Murali, Vaishnavi Balasubramaniam, Satish Srinivas, Sandhya Sundaram, Ganesh Venkatraman, Sudha Warrier, Arun Dharmarajan, Rajesh Kumar Gandhirajan   +7 more
openaire   +3 more sources

SteatoNet: the first integrated human metabolic model with multi-layered regulation to investigate liver-associated pathologies. [PDF]

PLoS Computational Biology, 2014
Current state-of-the-art mathematical models to investigate complex biological processes, in particular liver-associated pathologies, have limited expansiveness, flexibility, representation of integrated regulation and rely on the availability of ...
Adviti Naik, Damjana Rozman, Aleš Belič   +2 more
doaj   +1 more source

Biomarkers of stress-mediated metabolic deregulation in diabetes mellitus [PDF]

Diabetes Research and Clinical Practice, 2017
Cette revue illustre la relation entre le stress oxydatif et nitratif et le diabète sucré et ses complications. Ceci est d'un intérêt considérable car le diabète sucré est une maladie métabolique systémique à vie qui peut survenir pendant l'enfance ou l'âge adulte et affecte non seulement une triade d'insuline des cellules des îlots pancréatiques, d ...
Dina Johar, Larry Bernstein
openaire   +3 more sources

Immunometabolism features of metabolic deregulation and cancer

Journal of Cellular and Molecular Medicine, 2018
AbstractImmunometabolism is a branch dealing at the interface of immune functionalities and metabolic regulations. Considered as a bidirectional trafficking, metabolic contents and their precursors bring a considerable change in immune cells signal transductions which as a result affect the metabolic organs and states as an implication. Lipid metabolic
Xue Wang, Feng‐Feng Ping, Sahar Bakht, Jingjing Ling, Waseem Hassan   +4 more
openaire   +2 more sources

CHTM1, a novel metabolic marker deregulated in human malignancies [PDF]

Oncogene, 2018
A better understanding of the link between cellular metabolism and tumorigenesis is needed. Here, we report characterization of a novel protein named coiled-coil helix tumor and metabolism 1 (CHTM1). We have found that CHTM1 is associated with cancer and cellular metabolism.
Babbar, Mansi, Huang, Ying, An, Jie, Landas, Steve K., Sheikh, M. Saeed   +4 more
openaire   +2 more sources