Insights on Metabolic Reprogramming and Its Therapeutic Potential in Acute Leukemia [PDF]
, 2021 Acute leukemias, classified as acute myeloid leukemia and acute lymphoblastic leukemia, represent the most prevalent hematologic tumors in adolescent and young adults.
Ludovica Di Martino +3 more
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Epigenetic loss of AOX1 expression via EZH2 leads to metabolic deregulations and promotes bladder cancer progression. [PDF]
Oncogene, 2020 Vantaku V +22 more
europepmc +2 more sources
Metabolic Deregulation in Pulmonary Hypertension
Current Issues in Molecular Biology, 2023 The high morbidity and mortality rate of pulmonary arterial hypertension (PAH) is partially explained by metabolic deregulation. The present study complements our previous publication in “Genes” by identifying significant increases of the glucose transporter solute carrier family 2 (Slc2a1), beta nerve growth factor (Ngf), and nuclear factor erythroid ...
Rajamma Mathew +3 more
openaire +3 more sources
The Downregulation of the Liver Lipid Metabolism Induced by Hypothyroidism in Male Mice: Metabolic Flexibility Favors Compensatory Mechanisms in White Adipose Tissue. [PDF]
Int J Mol SciIn mammals, the maintenance of energy homeostasis relies on complex mechanisms requiring tight synchronization between peripheral organs and the brain.
Chamas L +4 more
europepmc +2 more sources
Deregulation of purine metabolism in Alzheimer's disease [PDF]
Neurobiology of Aging, 2015 The neuroprotective role of adenosine and the deregulation of adenosine receptors in Alzheimer's disease (AD) have been extensively studied in recent years. However, little is known about the involvement of purine metabolism in AD. We started by analyzing gene expression in the entorhinal cortex of human controls and AD cases with whole-transcript ...
Ansoleaga, Belén +8 more
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Deregulation of sphingolipid metabolism in Alzheimer's disease [PDF]
Neurobiology of Aging, 2010 Abnormal sphingolipid metabolism has been previously reported in Alzheimer's disease (AD). To extend these findings, several sphingolipids and sphingolipid hydrolases were analyzed in brain samples from AD patients and age-matched normal individuals. We found a pattern of elevated acid sphingomyelinase (ASM) and acid ceramidase (AC) expression in AD ...
Xingxuan, He +4 more
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Ubiquitous Aberration in Cholesterol Metabolism across Pancreatic Ductal Adenocarcinoma
Metabolites, 2022 Pancreatic cancer (PC) is characterized by metabolic deregulations that often manifest as deviations in metabolite levels and aberrations in their corresponding metabolic genes across the clinical specimens and preclinical PC models.
Venugopal Gunda +10 more
doaj +1 more source
NMR-based metabolomics combined with metabolic pathway analysis reveals metabolic heterogeneity of colorectal cancer tissue at different anatomical locations and stages. [PDF]
Int J CancerColorectal cancer (CRC) still remains the leading cause of cancer death worldwide. This study aimed to profile the metabolic differences of colorectal cancer tissues (CCT) at different stages and sites, as compared with their distant noncancerous tissues
Cai R +8 more
europepmc +2 more sources
Cells, 2022 Epigenetic alterations pose one major hallmark of organismal aging. Here, we provide an overview on recent findings describing the epigenetic changes that arise during aging and in related maladies such as neurodegeneration and cancer.
Anne-Marie Galow, Shahaf Peleg
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Toward Elucidating Epigenetic and Metabolic Regulation of Stem Cell Lineage Plasticity in Skin Aging
Frontiers in Cell and Developmental Biology, 2022 Skin is the largest organ in human body, harboring a plethora of cell types and serving as the organismal barrier. Skin aging such as wrinkling and hair graying is graphically pronounced, and the molecular mechanisms behind these phenotypic ...
Ying Lyu, Yejing Ge
doaj +1 more source