Results 11 to 20 of about 1,794 (242)

Deregulation of purine metabolism in Alzheimer's disease [PDF]

Neurobiology of Aging, 2015
The neuroprotective role of adenosine and the deregulation of adenosine receptors in Alzheimer's disease (AD) have been extensively studied in recent years. However, little is known about the involvement of purine metabolism in AD. We started by analyzing gene expression in the entorhinal cortex of human controls and AD cases with whole-transcript ...
Ansoleaga, Belén, Jove, Mariona, Schlüter, Agatha, Garcia Esparcia, Paula, Moreno Castro, Jesús, Pujol Onofre, Aurora, Pamplona, Reinald, Portero-Otin, Manuel, Ferrer, Isidro (Ferrer Abizanda)   +8 more
openaire   +3 more sources

Early postnatal soluble FGFR3 therapy prevents the atypical development of obesity in achondroplasia. [PDF]

PLoS ONE, 2018
Achondroplasia is a rare genetic disease is characterized by abnormal bone development and early obesity. While the bone aspect of the disease has been thoroughly studied, early obesity affecting approximately 50% of them during childhood has been ...
Celine Saint-Laurent, Stephanie Garcia, Vincent Sarrazy, Karine Dumas, Florence Authier, Sophie Sore, Albert Tran, Philippe Gual, Isabelle Gennero, Jean-Pierre Salles, Elvire Gouze   +10 more
doaj   +1 more source

Unraveling the Multifaceted Nature of CD8 T Cell Exhaustion Provides the Molecular Basis for Therapeutic T Cell Reconstitution in Chronic Hepatitis B and C

Cells, 2021
In chronic hepatitis B and C virus infections persistently elevated antigen levels drive CD8+ T cells toward a peculiar differentiation state known as T cell exhaustion, which poses crucial constraints to antiviral immunity.
Valeria Barili, Andrea Vecchi, Marzia Rossi, Ilaria Montali, Camilla Tiezzi, Amalia Penna, Diletta Laccabue, Gabriele Missale, Paola Fisicaro, Carolina Boni   +9 more
doaj   +1 more source

Deregulation of sphingolipid metabolism in Alzheimer's disease [PDF]

Neurobiology of Aging, 2010
Abnormal sphingolipid metabolism has been previously reported in Alzheimer's disease (AD). To extend these findings, several sphingolipids and sphingolipid hydrolases were analyzed in brain samples from AD patients and age-matched normal individuals. We found a pattern of elevated acid sphingomyelinase (ASM) and acid ceramidase (AC) expression in AD ...
Xingxuan, He, Yu, Huang, Bin, Li, Cheng-Xin, Gong, Edward H, Schuchman   +4 more
openaire   +2 more sources

Ubiquitous Aberration in Cholesterol Metabolism across Pancreatic Ductal Adenocarcinoma

Metabolites, 2022
Pancreatic cancer (PC) is characterized by metabolic deregulations that often manifest as deviations in metabolite levels and aberrations in their corresponding metabolic genes across the clinical specimens and preclinical PC models.
Venugopal Gunda, Thiago C. Genaro-Mattos, Jyoti B. Kaushal, Ramakanth Chirravuri-Venkata, Gopalakrishnan Natarajan, Kavita Mallya, Paul M. Grandgenett, Karoly Mirnics, Surinder K. Batra, Zeljka Korade, Satyanarayana Rachagani   +10 more
doaj   +1 more source

How to Slow down the Ticking Clock: Age-Associated Epigenetic Alterations and Related Interventions to Extend Life Span

Cells, 2022
Epigenetic alterations pose one major hallmark of organismal aging. Here, we provide an overview on recent findings describing the epigenetic changes that arise during aging and in related maladies such as neurodegeneration and cancer.
Anne-Marie Galow, Shahaf Peleg
doaj   +1 more source

High glucose induced c-Met activation promotes aggressive phenotype and regulates expression of glucose metabolism genes in HCC cells

Scientific Reports, 2021
Hepatocellular carcinoma (HCC) is strongly associated with metabolic dysregulations/deregulations and hyperglycemia is a common metabolic disturbance in metabolic diseases. Hyperglycemia is defined to promote epithelial to mesenchymal transition (EMT) of
Hande Topel, Ezgi Bağırsakçı, Yeliz Yılmaz, Ayşim Güneş, Gülsün Bağcı, Dehan Çömez, Erkan Kahraman, Peyda Korhan, Neşe Atabey   +8 more
doaj   +1 more source

Toward Elucidating Epigenetic and Metabolic Regulation of Stem Cell Lineage Plasticity in Skin Aging

Frontiers in Cell and Developmental Biology, 2022
Skin is the largest organ in human body, harboring a plethora of cell types and serving as the organismal barrier. Skin aging such as wrinkling and hair graying is graphically pronounced, and the molecular mechanisms behind these phenotypic ...
Ying Lyu, Yejing Ge
doaj   +1 more source

Deregulated coenzyme A, loss of metabolic flexibility and diabetes [PDF]

Biochemical Society Transactions, 2014
CoA (coenzyme A) is an essential cofactor that is emerging as a global regulator of energy metabolism. Tissue CoA levels are tightly regulated and vary in response to different conditions including nutritional state and diabetes. Recent studies reveal the ability of this cofactor to control the output of key metabolic pathways.
Suzanne, Jackowski, Roberta, Leonardi
openaire   +2 more sources

MLH1 deficiency leads to deregulated mitochondrial metabolism [PDF]

Cell Death & Disease, 2019
AbstractThe DNA mismatch repair (MMR) pathway is responsible for the repair of base–base mismatches and insertion/deletion loops that arise during DNA replication. MMR deficiency is currently estimated to be present in 15–17% of colorectal cancer cases and 30% of endometrial cancers.
Sukaina Rashid, Marta O. Freitas, Danilo Cucchi, Gemma Bridge, Zhi Yao, Laura Gay, Marc Williams, Jun Wang, Nirosha Suraweera, Andrew Silver, Stuart A. C. McDonald, Claude Chelala, Gyorgy Szabadkai, Sarah A. Martin   +13 more
openaire   +5 more sources