Results 11 to 20 of about 1,944 (252)
Medicina, 2019 Objectives: The aim of this study was to determine the incidence of metabolic syndrome in patients treated with second-generation antipsychotics (SGAs).
Osama Abo Alrob +7 more
doaj +2 more sources
SteatoNet: the first integrated human metabolic model with multi-layered regulation to investigate liver-associated pathologies. [PDF]
PLoS Computational Biology, 2014 Current state-of-the-art mathematical models to investigate complex biological processes, in particular liver-associated pathologies, have limited expansiveness, flexibility, representation of integrated regulation and rely on the availability of ...
Adviti Naik +2 more
doaj +2 more sources
Antioxidants, 2021 Atherosclerosis is the predominant pathology associated to premature deaths due to cardiovascular disease. However, early intervention based on a personalized diagnosis of cardiovascular risk is very limited.
Aranzazu Santiago-Hernandez +9 more
doaj +2 more sources
Scientific Reports, 2021 Hepatocellular carcinoma (HCC) is strongly associated with metabolic dysregulations/deregulations and hyperglycemia is a common metabolic disturbance in metabolic diseases. Hyperglycemia is defined to promote epithelial to mesenchymal transition (EMT) of
Hande Topel +8 more
doaj +2 more sources
The intensity of IUGR-induced transcriptome deregulations is inversely correlated with the onset of organ function in a rat model. [PDF]
PLoS ONE, 2011 A low-protein diet applied during pregnancy in the rat results in intrauterine growth restricted (IUGR) fetuses. In humans, IUGR is associated with increased perinatal morbidity, higher incidence of neuro-developmental defects and increased risk of adult
Daniel Vaiman +11 more
doaj +3 more sources
Molecular interactions between NAFLD and xenobiotic metabolism
Frontiers in Genetics, 2013 Non-alcoholic fatty liver disease (NAFLD), the hepatic manifestation of the metabolic syndrome, is a complex multifactorial disease characterised by metabolic deregulations that include accumulation of lipids in the liver, lipotoxicity and insulin ...
Adviti eNaik +3 more
doaj +2 more sources
Regulation and deregulation of cholesterol homeostasis: The liver as a metabolic "power station" [PDF]
World Journal of Hepatology, 2012 Cholesterol plays several structural and metabolic roles that are vital for human biology. It spreads along the entire plasma membrane of the cell, modulating fluidity and concentrating in specialized sphingolipid-rich domains called rafts and caveolae ...
SEGATTO, MARCO +2 more
core +4 more sources
Scientific Reports, 2017 Obesity increases susceptibility to multiple organ disorders, however, underlying mechanisms remain unclear. The subclinical inflammation assisted by obesity-induced gut permeability may underlie obesity-associated co-morbidities.
Rizwan Ahmad +4 more
doaj +3 more sources
Investigating the deregulation of metabolic tasks via Minimum Network Enrichment Analysis (MiNEA) as applied to nonalcoholic fatty liver disease using mouse and human omics data. [PDF]
PLoS Computational Biology, 2019 Nonalcoholic fatty liver disease (NAFLD) is associated with metabolic syndromes spanning a wide spectrum of diseases, from simple steatosis to the more complex nonalcoholic steatohepatitis.
Vikash Pandey, Vassily Hatzimanikatis
doaj +2 more sources
Metabolic deregulation in prostate cancer [PDF]
Molecular Omics, 2018 Abstract Introduction: The prostate exhibits a unique metabolism that changes during initial neoplasia to aggressive prostate cancer (PCa) and metastasis. The study of PCa metabolism thus represents a new avenue for diagnostics, particularly early diagnosis of aggressive PCa cases.
Sriganesh Srihari +5 more
openaire +6 more sources