Results 31 to 40 of about 1,794 (242)
Molecular interactions between NAFLD and xenobiotic metabolism
Frontiers in Genetics, 2013 Non-alcoholic fatty liver disease (NAFLD), the hepatic manifestation of the metabolic syndrome, is a complex multifactorial disease characterised by metabolic deregulations that include accumulation of lipids in the liver, lipotoxicity and insulin ...
Adviti eNaik +3 more
doaj +1 more source
Formation of benign tumors by stem cell deregulation.
PLoS Genetics, 2022 Within living organisms, stem cells respond to various cues, including to niche signals and growth factors. Niche signals originate from the stem cell's microenvironment and promote the undifferentiated state by preventing differentiation, allowing for ...
Matthieu Valet, Patrick Narbonne
doaj +1 more source
Deregulation of RNA Metabolism in Microsatellite Expansion Diseases [PDF]
, 2018 RNA metabolism impacts different steps of mRNA life cycle including splicing, polyadenylation, nucleo-cytoplasmic export, translation, and decay. Growing evidence indicates that defects in any of these steps lead to devastating diseases in humans. This chapter reviews the various RNA metabolic mechanisms that are disrupted in Myotonic Dystrophy-a ...
Chaitali, Misra +2 more
openaire +2 more sources
Deregulated Lysophosphatidic Acid Metabolism and Signaling in Liver Cancer [PDF]
Cancers, 2019 Liver cancer is one of the leading causes of death worldwide due to late diagnosis and scarcity of treatment options. The major risk factor for liver cancer is cirrhosis with the underlying causes of cirrhosis being viral infection (hepatitis B or C), metabolic deregulation (Non-alcoholic fatty liver disease (NAFLD) in the presence of obesity and ...
Eleanna Kaffe +2 more
openaire +2 more sources
Molecules, 2021 Metabolic disorders often lead to cardiac complications. Metabolic deregulations during diabetic conditions are linked to mitochondrial dysfunctions, which are the key contributing factors in cardiac hypertrophy.
Iram Mushtaq +12 more
doaj +1 more source
MiR-22 Deficiency Fosters Hepatocellular Carcinoma Development in Fatty Liver
Cells, 2022 MiR-22 is mostly considered as a hepatic tumor-suppressor microRNA based on in vitro analyses. Yet, whether miR-22 exerts a tumor-suppressive function in the liver has not been investigated in vivo.
Monika Gjorgjieva +9 more
doaj +1 more source
Scientific Reports, 2017 Obesity increases susceptibility to multiple organ disorders, however, underlying mechanisms remain unclear. The subclinical inflammation assisted by obesity-induced gut permeability may underlie obesity-associated co-morbidities.
Rizwan Ahmad +4 more
doaj +1 more source
Medicina, 2019 Objectives: The aim of this study was to determine the incidence of metabolic syndrome in patients treated with second-generation antipsychotics (SGAs).
Osama Abo Alrob +7 more
doaj +1 more source
Regulation and deregulation of cholesterol homeostasis: The liver as a metabolic “power station” [PDF]
World Journal of Hepatology, 2012 Cholesterol plays several structural and metabolic roles that are vital for human biology. It spreads along the entire plasma membrane of the cell, modulating fluidity and concentrating in specialized sphingolipid-rich domains called rafts and caveolae. Cholesterol is also a substrate for steroid hormones.
Trapani Laura +2 more
openaire +3 more sources
Metabolic Deregulation of the Blood-Outer Retinal Barrier in Retinitis Pigmentosa [PDF]
Cell Reports, 2019 Retinitis pigmentosa (RP) initiates with diminished rod photoreceptor function, causing peripheral and night-time vision loss. However, subsequent loss of cone function and high-resolution daylight and color vision is most debilitating. Visual pigment-rich photoreceptor outer segments (OS) undergo phagocytosis by the retinal pigment epithelium (RPE ...
Wei Wang +19 more
openaire +3 more sources