Results 31 to 40 of about 1,944 (252)

Deregulated coenzyme A, loss of metabolic flexibility and diabetes [PDF]

Biochemical Society Transactions, 2014
CoA (coenzyme A) is an essential cofactor that is emerging as a global regulator of energy metabolism. Tissue CoA levels are tightly regulated and vary in response to different conditions including nutritional state and diabetes. Recent studies reveal the ability of this cofactor to control the output of key metabolic pathways.
Suzanne, Jackowski, Roberta, Leonardi
openaire   +2 more sources

Metabolic characterisation of transglutaminase 2 inhibitor effects in breast cancer cell lines [PDF]

, 2023
Transglutaminase 2 (TG2), which mediates post-translational modifications of multiple intracellular enzymes, is involved in the pathogenesis and progression of cancer.
Taccioli, Cristian, Elena Ferrari, Cristian Taccioli, Bergamini, Carlo M, Anna Terrazzan, Spisni, Alberto, Mariana Gallo, Gallo, Mariana, Nicoletta Bianchi, Jeffrey W. Keillor, Stefano Volinia, Ferrari, Elena, Federica Brugnoli, Gianluca Aguiari, Thelma A. Pertinhez, Keillor, Jeffrey W, Brugnoli, Federica, Bianchi, Nicoletta, Carlo M. Bergamini, Trentini, Alessandro, Alberto Spisni, Alessandro Trentini, Volinia, Stefano, Pertinhez, Thelma A, Aguiari, Gianluca, Terrazzan, Anna   +25 more
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MLH1 deficiency leads to deregulated mitochondrial metabolism [PDF]

Cell Death & Disease, 2019
AbstractThe DNA mismatch repair (MMR) pathway is responsible for the repair of base–base mismatches and insertion/deletion loops that arise during DNA replication. MMR deficiency is currently estimated to be present in 15–17% of colorectal cancer cases and 30% of endometrial cancers.
Sukaina Rashid, Marta O. Freitas, Danilo Cucchi, Gemma Bridge, Zhi Yao, Laura Gay, Marc Williams, Jun Wang, Nirosha Suraweera, Andrew Silver, Stuart A. C. McDonald, Claude Chelala, Gyorgy Szabadkai, Sarah A. Martin   +13 more
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Targeting Metabolic Deregulation Landscapes in Breast Cancer Subtypes [PDF]

Frontiers in Oncology, 2020
Metabolic deregulation is an emergent hallmark of cancer. Altered patterns of metabolic pathways result in exacerbated synthesis of macromolecules, increased proliferation, and resistance to treatment via alteration of drug processing. In addition, molecular heterogeneity creates a barrier to therapeutic options.
Erandi A. Serrano-Carbajal, Jesús Espinal-Enríquez, Jesús Espinal-Enríquez, Enrique Hernández-Lemus, Enrique Hernández-Lemus   +4 more
openaire   +3 more sources

Tumor Cells and Cancer-Associated Fibroblasts: An Updated Metabolic Perspective

, 2021
During the past decades, metabolism and redox imbalance have gained considerable attention in the cancer field. In addition to the well-known Warburg effect occurring in tumor cells, numerous other metabolic deregulations have now been reported.
Fatima Mechta-Grigoriou, Géraldine Gentric   +1 more
core   +1 more source

Muscle and Bone Impairment in Infantile Nephropathic Cystinosis: New Concepts

Cells, 2022
Cystinosis Metabolic Bone Disease (CMBD) has emerged during the last decade as a well-recognized, long-term complication in patients suffering from infantile nephropathic cystinosis (INC), resulting in significant morbidity and impaired quality of life ...
Dieter Haffner, Maren Leifheit-Nestler, Candide Alioli, Justine Bacchetta   +3 more
doaj   +1 more source

The role of epigenetic modulators on circadian rhythms and metabolism

, 2022
The earth’s rotation on its axis with a 24-hour period gave rise to circadian rhythms, which originated pervasive biologic fluctuations in gene expression, cellular physiology and whole-organism behaviour.
Mosneagu, Dragos
core   +1 more source

Deregulated Metabolic Pathways in Ovarian Cancer: Cause and Consequence

Metabolites, 2023
Ovarian cancers are tumors that originate from the different cells of the ovary and account for almost 4% of all the cancers in women globally. More than 30 types of tumors have been identified based on the cellular origins. Epithelial ovarian cancer (EOC) is the most common and lethal type of ovarian cancer which can be further divided into high-grade
Roopak Murali, Vaishnavi Balasubramaniam, Satish Srinivas, Sandhya Sundaram, Ganesh Venkatraman, Sudha Warrier, Arun Dharmarajan, Rajesh Kumar Gandhirajan   +7 more
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Deregulation of Lipid Metabolism: The Critical Factors in Ovarian Cancer [PDF]

Frontiers in Oncology, 2020
Ovarian cancer is one of the most malignant gynecological cancers around the world. In spite of multiple treatment options, the five-year survival rate is still very low. Several metabolism alterations are described as a hallmark in cancers, but alterations of lipid metabolism in ovarian cancer have been paid less attention.
Zhaodong Ji, Zhaodong Ji, Yan Shen, Xu Feng, Xu Feng, Yue Kong, Yue Kong, Yang Shao, Yang Shao, Jiao Meng, Jiao Meng, Xiaofei Zhang, Gong Yang, Gong Yang, Gong Yang   +14 more
openaire   +3 more sources

Mass Spectrometry-Based Peptide Profiling of Haemolymph from Pterostichus melas Exposed to Pendimethalin Herbicide

Molecules, 2022
Pendimethalin-based herbicides are used worldwide for pre-emergence selective control of annual grasses and weeds in croplands. The endurance of herbicides residues in the environment has an impact on the soil biodiversity and fertility, also affecting ...
Donatella Aiello, Anita Giglio, Federica Talarico, Maria Luigia Vommaro, Antonio Tagarelli, Anna Napoli   +5 more
doaj   +1 more source