Results 31 to 40 of about 1,855,857 (359)

A dynamic network approach for the study of human phenotypes [PDF]

, 2009
The use of networks to integrate different genetic, proteomic, and metabolic datasets has been proposed as a viable path toward elucidating the origins of specific diseases.
A Barrat, A Hinks, A Rzhetsky, AB Begovich, AJ Lusis, Albert-László Barabási, C Benesch, CA Hidalgo, CA Hidalgo, César A. Hidalgo, D Lauderdale, DS Lee, GS Cooper, H Goehler, I Feldman, J Hatten, J Kobberling, J Lim, J Zhang, JB Mitchell, JF Rual, K-I Goh, Lauren Ancel Meyers, LI Iezzoni, MA Pujana, MC Oldham, N Craddock, Nicholas A. Christakis, Nicholas Blumm, P McGuffin, P Wordsworth, S Schneeweiss, SE Ahnert, SE Calvano, SF Grant, U Stelzl   +35 more
core   +5 more sources

Sodium butyrate potentiates insulin secretion from rat islets at the expense of compromised expression of β cell identity genes

Cell Death and Disease, 2022
Short-chain fatty acids (SCFAs) produced by the gut microbiota have been well demonstrated to improve metabolic homeostasis. However, the role of SCFAs in islet function remains controversial.
Shushu Wang, Miaomiao Yuan, Linlin Zhang, Kecheng Zhu, Chunxiang Sheng, Feiye Zhou, Zhaoqian Xu, Qianqian Liu, Yun Liu, Jieli Lu, Xiao Wang, Libin Zhou   +11 more
doaj   +1 more source

Sexual dimorphism in glucose metabolism is shaped by androgen-driven gut microbiome

Nature Communications, 2021
Male sex is a risk factor for impaired glucose metabolism and type 2 diabetes. Here the authors identify that androgen modulates the gut microbiome, which drives insulin resistance and contributes to sexual dimorphism in glucose metabolism in mice.
Aibo Gao, Junlei Su, Ruixin Liu, Shaoqian Zhao, Wen Li, Xiaoqiang Xu, Danjie Li, Juan Shi, Bin Gu, Juan Zhang, Qi Li, Xiaolin Wang, Yifei Zhang, Yu Xu, Jieli Lu, Guang Ning, Jie Hong, Yufang Bi, Weiqiong Gu, Jiqiu Wang, Weiqing Wang   +20 more
doaj   +1 more source

血清低密度脂蛋白胆固醇浓度与糖尿病风险之间的关联: 一项前瞻性队列研究

Journal of Diabetes, 2023
Background Low‐density lipoprotein cholesterol (LDL‐C) and diabetes mellitus are both modifiable risk factors for cardiovascular disease; however, whether elevated LDL‐C levels confer a risk for diabetes remains unclear. Objective We aimed to examine the
Jiaojiao Huang, Hong Lin, Shuangyuan Wang, Mian Li, Tiange Wang, Zhiyun Zhao, Yu Xu, Min Xu, Jieli Lu, Yuhong Chen, Guang Ning, Weiqing Wang, Yufang Bi, Long Wang   +13 more
doaj   +1 more source

The Role of Higher Protein Diets in the Regulation of Mood and Sleep in Patients with Metabolic Syndrome [PDF]

, 2020
Metabolic Syndrome is becoming a more prevalent health issue within the United States, currently affecting 22% of adults (Capuron et al., 2008). Several factors contribute to the diagnosis of Metabolic Syndrome, including obesity, high levels of ...
Fellinger, McKenzie
core   +2 more sources

Circadian rhythms and hormonal homeostasis: Pathophysiological implications [PDF]

, 2017
Over recent years, a deeper comprehension of the molecular mechanisms that control biological clocks and circadian rhythms has been achieved. In fact, many studies have contributed to unravelling the importance of the molecular clock for the regulation ...
Bruscalupi, Giovannella, Gnocchi, Davide
core   +2 more sources

BMP9 reduces age-related bone loss in mice by inhibiting osteoblast senescence through Smad1-Stat1-P21 axis

Cell Death Discovery, 2022
BMP9 inhibits cellular senescence by activation of Smad1, which suppresses the transcription of Stat1, resulting in decreased P21 expression and SASPs production in osteoblast.
Jing-zun Xu, Yan-man Zhou, Lin-lin Zhang, Xiao-jing Chen, Yu-ying Yang, Deng Zhang, Ke-cheng Zhu, Xiao-ke Kong, Li-hao Sun, Bei Tao, Hong-yan Zhao, Jian-min Liu   +11 more
doaj   +1 more source

The spleen: a hub connecting nervous and immune systems in cardiovascular and metabolic diseases [PDF]

, 2017
Metabolic disorders have been identified as major health problems affecting a large portion of the world population. In addition, obesity and insulin resistance are principal risk factors for the development of cardiovascular diseases.
Carnevale, Daniela, Lembo, Giuseppe, Lori, Andrea, Perrotta, Marialuisa   +3 more
core   +2 more sources

生命早期饥荒暴露与晚年代谢综合征风险之间的关联

Journal of Diabetes, 2022
Background Previous studies reported that famine exposure had an effect on metabolic syndrome (MetS). However, there is an inadequacy of study regarding the association between famine exposure, adulthood general obesity, and the risk of MetS.
Yi Zhang, Hongyan Qi, Chunyan Hu, Shuangyuan Wang, Yuanyue Zhu, Hong Lin, Lin Lin, Jie Zhang, Tiange Wang, Zhiyun Zhao, Mian Li, Yu Xu, Min Xu, Yufang Bi, Weiqing Wang, Yuhong Chen, Jieli Lu, Guang Ning   +17 more
doaj   +1 more source

Branched-Chain Amino Acid Negatively Regulates KLF15 Expression via PI3K-AKT Pathway. [PDF]

, 2017
Recent studies have linked branched-chain amino acid (BCAA) with numerous metabolic diseases. However, the molecular basis of BCAA's roles in metabolic regulation remains to be established.
Dong, Weibing, Liu, Yunxia, Shao, Jing, Sun, Haipeng, Wang, Yibin, Zhou, Meiyi   +5 more
core   +2 more sources