Results 31 to 40 of about 996,145 (295)

Sodium butyrate potentiates insulin secretion from rat islets at the expense of compromised expression of β cell identity genes

Cell Death and Disease, 2022
Short-chain fatty acids (SCFAs) produced by the gut microbiota have been well demonstrated to improve metabolic homeostasis. However, the role of SCFAs in islet function remains controversial.
Shushu Wang, Miaomiao Yuan, Linlin Zhang, Kecheng Zhu, Chunxiang Sheng, Feiye Zhou, Zhaoqian Xu, Qianqian Liu, Yun Liu, Jieli Lu, Xiao Wang, Libin Zhou   +11 more
doaj   +1 more source

Is Cancer a Metabolic Disease? [PDF]

The American Journal of Pathology, 2014
Although cancer has historically been viewed as a disorder of proliferation, recent evidence has suggested that it should also be considered a metabolic disease. Growing tumors rewire their metabolic programs to meet and even exceed the bioenergetic and biosynthetic demands of continuous cell growth. The metabolic profile observed in cancer cells often
openaire   +3 more sources

血清低密度脂蛋白胆固醇浓度与糖尿病风险之间的关联: 一项前瞻性队列研究

Journal of Diabetes, 2023
Background Low‐density lipoprotein cholesterol (LDL‐C) and diabetes mellitus are both modifiable risk factors for cardiovascular disease; however, whether elevated LDL‐C levels confer a risk for diabetes remains unclear. Objective We aimed to examine the
Jiaojiao Huang, Hong Lin, Shuangyuan Wang, Mian Li, Tiange Wang, Zhiyun Zhao, Yu Xu, Min Xu, Jieli Lu, Yuhong Chen, Guang Ning, Weiqing Wang, Yufang Bi, Long Wang   +13 more
doaj   +1 more source

生命早期饥荒暴露与晚年代谢综合征风险之间的关联

Journal of Diabetes, 2022
Background Previous studies reported that famine exposure had an effect on metabolic syndrome (MetS). However, there is an inadequacy of study regarding the association between famine exposure, adulthood general obesity, and the risk of MetS.
Yi Zhang, Hongyan Qi, Chunyan Hu, Shuangyuan Wang, Yuanyue Zhu, Hong Lin, Lin Lin, Jie Zhang, Tiange Wang, Zhiyun Zhao, Mian Li, Yu Xu, Min Xu, Yufang Bi, Weiqing Wang, Yuhong Chen, Jieli Lu, Guang Ning   +17 more
doaj   +1 more source

Long-term continuous N-carbamylglutamate treatment in frequently decompensated propionic acidemia: a case report

Journal of Medical Case Reports, 2018
Background Propionic acidemia is a rare autosomal recessive inherited metabolic disorder that can inhibit the synthesis of N-acetylglutamate, the obligatory activator in urea synthesis, leading to hyperammonemia.
Albina Tummolo, Livio Melpignano, Antonella Carella, Anna Maria Di Mauro, Elvira Piccinno, Marcella Vendemiale, Federica Ortolani, Stefania Fedele, Maristella Masciopinto, Francesco Papadia   +9 more
doaj   +1 more source

Placental metabolism and disease [PDF]

Placenta, 2018
Regular
openaire   +6 more sources

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

与糖尿病相关的家族史, 生活方式和代谢危险因素的全面风险描述:一项前瞻性队列研究

Journal of Diabetes, 2022
Background Family history of diabetes, unhealthy lifestyles, and metabolic disorders are individually associated with higher risk of diabetes, but how different combinations of the three risk categories are associated with incident diabetes remains ...
Chaojie Ye, Yiying Wang, Lijie Kong, Zhiyun Zhao, Mian Li, Yu Xu, Min Xu, Jieli Lu, Shuangyuan Wang, Hong Lin, Yuhong Chen, Weiqing Wang, Guang Ning, Yufang Bi, Tiange Wang   +14 more
doaj   +1 more source

Sphingolipid metabolism diseases

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2006
Human diseases caused by alterations in the metabolism of sphingolipids or glycosphingolipids are mainly disorders of the degradation of these compounds. The sphingolipidoses are a group of monogenic inherited diseases caused by defects in the system of lysosomal sphingolipid degradation, with subsequent accumulation of non-degradable storage material ...
Thomas Kolter, Konrad Sandhoff
openaire   +3 more sources

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source